Testicular cancer trends in the Canton of Vaud, Switzerland, 1974–1987

Levi, Fabio; Te, Van‐Cong; Vecchia, Carlo La

doi:10.1038/bjc.1990.398

Cited by 26 publications

(8 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The increase in age-standardized incidence of testicular cancer in Denmark is consistent with similar changes in a number of other populations of European origin (Coleman et al, 1993), with the possible exception of Switzerland where the age-adjusted incidence rate is high and seems to have been stable in the last 2-3 decades (Levi et al, 1990).…”

Section: Testiculur Cancersupporting

confidence: 77%

Trends in incidence of testicular cancer and prostate cancer in Denmark

Møller

2001

APMIS

View full text Add to dashboard Cite

This article presents a detailed analysis of the incidence trends of testicular cancer and prostate cancer, using information from the Danish Cancer Registry in the period 1943–1996. The rate of increase of testicular cancer was about 2.6% per year. The analyses indicated that incidence was more strongly dependent on the man's birth cohort than on the calendar period. The analysis confirmed the significantly reduced incidence of testicular cancer in the 1943 cohort and suggested a levelling off in the increase in testicular cancer incidence from cohorts born after around 1963. This may imply that the great part of the recent increase in incidence has been due to a rapid increase in incidence in successive birth cohorts born in the relatively short period from 1945 to 1960. The rate of increase of prostate cancer was about 1.6% per year. The analyses indicated a stronger dependency on period than on birth cohort. The cohort parameters had very low values in the three earliest cohorts (1858–1868) and the period parameters showed a low incidence in the most recent period. The epidemiological pattern of prostate cancer incidence seems dominated by changes in diagnosis and registration and does not permit inferences about changes in causal factors.

show abstract

Section: Testiculur Cancersupporting

confidence: 77%

Trends in incidence of testicular cancer and prostate cancer in Denmark

Møller

2001

APMIS

View full text Add to dashboard Cite

show abstract

“…The variability in the geographical and temporal patterns within Europe is extensive: a 5-fold variation in incidence rates was observed, and there was a steady rise in incidence across populations that varied from 1 to 6% per annum. Rates rose most rapidly in low-risk Spain and intermediate-risk Slovenia, with Switzerland being the exception to the increasing profile, for which rates have been extremely high but stable over several decades, 38 with recent declines additionally suggested in this study. It can be speculated that a leveling off of incidence in high-risk countries may represent a mature phase in the epidemic, relative to lower-risk countries for which this phenomenon might be considered to be at an early phase, with further increases anticipated in forthcoming years.…”

Section: Discussionmentioning

confidence: 91%

Trends in testicular cancer incidence and mortality in 22 European countries: Continuing increases in incidence and declines in mortality

Bray

Richiardi

Ekbom

et al. 2006

Intl Journal of Cancer

288

197

View full text Add to dashboard Cite

This study profiles testicular cancer incidence and mortality across Europe, and the effects of age, period and generational influences, using age-period-cohort modeling. Despite a 5-fold variation in incidence rates, there were consistent mean increases in incidence in each of the 12 European countries studied, ranging from around 6% per annum (Spain and Slovenia) to 1-2% (Norway). In contrast, declines in testicular cancer mortality of 3-6% per annum were observed in the 1980s and 1990s for the majority of the 22 countries studied, particularly in Northern and Western Europe. The mortality trends in several European countries were rather stable (Romania and Bulgaria) or increasing (Portugal and Croatia). Short-term attenuations in increasing cohort-specific risk of incidence were indicated among men born between 1940 and 1945 in 7 European countries. In Switzerland, successive generations born from the mid 1960s may have experienced a steadily declining risk of disease occurrence. While the underlying risk factors responsible remain elusive, the temporal and geographical variability in incidence may point to an epidemic in different phases in different countries-the result of country-specific differences in the prevalence of one or several ubiquitous and highly prevalent environmental determinants of the disease. Advances in treatment have led to major declines in mortality in many European countries from the mid 1970s, which has translated to cohorts of men at successively lower risk of death from the disease. Slower progress in the delivery of optimal care is however evident from the mortality trends in several lower-resource countries in Southern and Eastern Europe. The first beneficiaries of therapy in these populations may be those men born-rather than diagnosed-in the era of major breakthrough in testicular cancer care. ' 2006 Wiley-Liss, Inc.Key words: testicular cancer; incidence; mortality; time trends; epidemiology Testicular cancer accounts for 1-3% of all cancers in males in Western countries, but is the most common malignancy among young men (aged 15-34 years) in most European populations. 1 The highest incidence rates are recorded in a number of countries in Northern (Denmark, Norway), Central (Germany, Switzerland) and Eastern Europe (Czech Republic). 2 Incidence trends in almost all European populations are characterized by rapid increases in the last few decades, 3-7 particularly in adolescent men and young adults. 8 The etiology of testicular cancer is not well understood, and the underlying reasons for the steadily increasing incidence trends throughout Europe are largely unknown. Improving ascertainment and better diagnostic procedures cannot account for the estimated 3-5% rises in incidence per annum, as the course of the disease is rapidly fatal if left untreated. In addition, the consistent evidence of uniformly rising secular trends comes from a number of wellestablished European cancer registries with standardized procedures. 4 It has been hypothesized that the risk of testicular canc...

show abstract

“…The age-specific incidence differs between these two forms, non-seminomas having an age-specific incidence peak in the age group of 25-29 years and the seminomas 35-39 years (Heimdul et al 1990;Schottenfeld et al 1980). The incidence of the two histopathological forms are strongly correlated: populations with a high incidence of seminoma also have a high incidence of nonseminoma and vice versa (Levi et al 1990). This indicates common or similar etiological factors for the two histopathological forms, especially as mixed forms occur quite frequently.…”

Section: Swedenmentioning

confidence: 99%

“…1992;Wilkinson et al 1992;Osterlind 1986). There are at least two noteworthy exceptions: 1) the incidence in the Afro-American population in the United States is low and do not show any upward trend (Van den Eden & Weiss 1989); 2) an incidence study of testicular cancer trends in the canton of Vaud, Switzerland, 1974-1987, showed a stable annual incidence (Levi et al 1990) albeit with one of the highest annual incidences (about 10 per 100,000 males) ever reported. Switzerland, Denmark and New Zealand (Parkin e l al.…”

Section: Swedenmentioning

confidence: 99%

Increasing incidence of testicular cancer — birth cohort effects

Ekbom

Akre

1998

APMIS

View full text Add to dashboard Cite

Ekbom, A. & Akre, 0. Increasing incidence of testicular cancerbirth cohort effects. APMIS 106: [225][226][227][228][229][230][231] 1998.The incidence of testicular cancer is rising in most Western populations. A collaborative study between nine population-based cancer registries in countries around the Baltic Sea was utilized in order to analyze in detail geographic variations and temporal trends in the occurrence of testicular cancer. There were 34,309 cases registered up until 1989 starting in Denmark in 1942 and most recently in Latvia in 1977. From the descriptive epidemiology it was obvious that there was a substantial variation in the age-standardized incidence amounting to about a 10-fold difference between the different countries ranging from 0.8 per 100,000 person-years in Lithuania to 7.6 per 100,000 person-years in Denmark. Previous studies have indicated that this increase is due to birth cohort effects. A more detailed analysis was therefore performed in those six countries with a sufficiently long period of cancer registration; Poland, former East Germany, Norway, Finland, Denmark and Sweden. This analysis showed that birth cohort is a more important determinant of testicular cancer risk than year of diagnosis. In Poland, former East Germany and Finland, there was an increasing risk for all birth cohorts. Among men born in Denmark, Norway or Sweden between 1930 and 1945, this increasing trend in risk was interrupted in these birth cohorts but followed thereafter by an uninterrupted increase by birth cohort. In conclusion, life time exposure to environmental factors which are associated with the incidence of testicular cancer appear to be more related to birth cohort than to year of diagnosis. Because testicular cancer typically occurs at an early age, major etiological factors therefore need to operate early in life, perhaps even in utero.

show abstract

Testicular cancer trends in the Canton of Vaud, Switzerland, 1974–1987

Cited by 26 publications

References 18 publications

Trends in incidence of testicular cancer and prostate cancer in Denmark

Trends in incidence of testicular cancer and prostate cancer in Denmark

Trends in testicular cancer incidence and mortality in 22 European countries: Continuing increases in incidence and declines in mortality

Increasing incidence of testicular cancer — birth cohort effects

Contact Info

Product

Resources

About