Testicular Changes in Subfertile Males with Varicocele

Etriby, Anwar; Girgis, S. M.; El-Hefnawy, Hala M; Ibrahim, Abdalla

doi:10.1016/s0015-0282(16)36428-7

Cited by 72 publications

(10 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found that the most detrimental effects on semen quality and testicular histology occurred in patients with large varicoceles and the most beneficial effects were obtained after operation on small varicoceles. These results confirm those of Etriby et al (1967) and Tinga et al (1984). This difference in results may be due to the fact that Johnsen and Agger (1978) did not include small varicoceles in their statistical calculations.…”

Section: Discussionsupporting

confidence: 65%

Testicular Morphology and Function in Varicocele Patients: Pre‐operative and Post‐operative Histopathology

Abdel-Rahim

Mostafa

Hamdy

et al. 1993

British Journal of Urology

View full text Add to dashboard Cite

The organic effects of varicocele on testicular histology were studied in bilateral testicular biopsies obtained from 30 infertile men during varicocele repair and 3 to 6 months post-operatively, using light microscopy. Before surgery and at follow-up, semen analyses were performed. The results showed a substantial improvement in semen quality in 22 cases post-operatively. Pre-operative biopsies showed depressed spermatogenesis with a predominant picture of maturation arrest, sloughing of spermatogenic epithelium, an increase in Leydig cells, thickening of tubular basement membranes and interstitial blood vessel walls with narrowing of their lumina, and increased deposition of interstitial fibrous tissue. Post-operatively, spermatogenesis improved in 22 cases, with increased mean tubular scores together with diminution in epithelial cell sloughing. The increased prominence of Leydig cells reverted to normal in 18 cases. The changes in tubular basement membranes, interstitium and interstitial blood vessels were unaffected.

show abstract

Section: Discussionsupporting

confidence: 65%

Testicular Morphology and Function in Varicocele Patients: Pre‐operative and Post‐operative Histopathology

Abdel-Rahim

Mostafa

Hamdy

et al. 1993

British Journal of Urology

View full text Add to dashboard Cite

show abstract

“…The quantity of Leydig cells was normalized in eighteen patients. Other studies of varicocele patients have found Sertoli cell only syndrome19, spermatogenic arrest20, and hypo- or normo-spermatogenesis 21…”

Section: Pathophysiologymentioning

confidence: 93%

The great debate: varicocele treatment and impact on fertility

Will

Swain

Fode

et al. 2011

Fertility and Sterility

140

103

View full text Add to dashboard Cite

Objective-To evaluate the current literature on the impact and potential mechanisms of varicocele repair on male fertility.Design-Pertinent articles were identified through computer PubMed search on varicocele repair and male infertility. References of selected articles were hand searched for additional citations.Conclusions-Varicocele repair has been shown to reverse a spectrum of effects contributing to men with impaired fertility. Clinical studies on the intervention have illustrated variable effects on postoperative sperm parameters and pregnancy rates. Studies with conflicting results suffer from a significant number of confounding variables, such variable repair technique or lack of controls. Further studies are warranted on the role of modern microsurgical varicocelectomy given the improvements in assisted reproductive technologies.

show abstract

“…The tubular morphology in these patients usually presents hypospermatogenesis, maturation arrest, sloughing or a mixed Sertoli-only pattern or even a Ser toli-cell-only pattern [Etriby et al, 1969;McFadden and Mehan, 1978;Codesal et al, 1985].…”

Section: Introductionmentioning

confidence: 99%