Testicular effects of monensin, a golgi interfering agent in male rats

Singh, Malti; Kalla, N.R.; Sanyal, Sankar Nath

doi:10.3109/01480545.2013.866955

Cited by 7 publications

(1 citation statement)

References 32 publications

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“…WPBs predominantly contained the coagulation protein Von Willebrand factor (vWF) which was secreted by the cell upon vascular damage (Mourik, Faas, Zimmermann, Eikenboom, & Koster, ). However, the capability of human endothelial cells to synthesize and store vWF was impaired by the presence of monensin which had the ability to alter the transmembrane ionic exchange to cause the disintegration of Golgi structure and perturb biological function of GA (Singh, Kalla, & Sanyal, ; Wagner, Mayadas, Urban‐Pickering, Lewis, & Marder, ) (Table ). Furthermore, the prolonged stimulation of primary human endothelial cells with inflammatory mediators also resulted in accumulation of IL‐8 in WPBs, where it colocalized with vWF (Wolff, Burns, Middleton, & Rot, ).…”

Section: Dysfunction Of the Golgi Apparatus Is Associated With Cardiomentioning

confidence: 99%

The significant role of the Golgi apparatus in cardiovascular diseases

Zhou

Chen

et al. 2017

Journal Cellular Physiology

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The Golgi apparatus (GA) is a ribbon-like system of stacks which consist of multiple closely apposed flattened cisternae and vesicles usually localized in the juxta-nuclear area. As for the biological functions, the GA plays a major role in protein biosynthesis, post-translational modification, and sorting protein from ER to plasma membrane and other destinations. Structural changes and functional disorder of the GA is associated with various diseases. Moreover, increasing evidence revealed that swelling, poor development, and other morphological alterations of the GA are linked to cardiovascular diseases such as heart failure (HF), arrhythmia, and dilated cardiomyopathy. Furthermore, dysfunction of the GA is also related to cardiovascular diseases since the GA is extremely responsible for transport, glycosylation, biosynthesis, and subcellular distribution of cardiovascular proteins. This review gives a brief overview of the intricate relationship between the GA and cardiovascular diseases. In addition, we provide a further prospective that the GA may provide diagnosis reference for cardiovascular diseases, and changes in the ultrastructure and morphology of the GA such as swelling, poor development, and fragmentation may serve as a reliable index for cardiovascular diseases.

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Section: Dysfunction Of the Golgi Apparatus Is Associated With Cardiomentioning

confidence: 99%