Testicular Function, Semen Quality, and Fertility in Young Men After Renal Transplantation During Childhood or Adolescence

Tainio, Juuso; Jahnukainen, Kirsi; Nurmio, Mirja; Pakarinen, Mikko P.; Jalanko, Hannu; Jahnukainen, Timo

doi:10.1097/tp.0000000000000173

Cited by 28 publications

(27 citation statements)

References 35 publications

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“…Secondly, we focused only on male patients and excluded those with significant co-morbidities since this study is part of a larger follow-up study evaluating fertility and quality of life in young men after pediatric KTx. 2,32 Thirdly, we used previously recruited control groups and, thus, we could not perfectly match the cohorts by their age and relevant medical history. NBL survivors were significantly younger at the time of diagnosis than the KTx recipients at initiation of dialysis, and they had a longer history with severe chronic disease than the KTx patients.…”

Section: Discussionmentioning

confidence: 99%

“…This study was part of our previous study on the long-term survival, fertility, and sexual health in young men with a history of KTx during childhood. 2 All male KTx recipients operated between August 1983 and September 2011 were identified from our transplant database. The inclusion criteria were age >18 years and post-transplant follow-up time >5 years with a functioning graft.…”

Section: Study Populationmentioning

confidence: 99%

“…There is increasing evidence that patients with a history of chronic disease and exposure to cytotoxic medication are prone to secondary complications, mainly affecting hormonal function, the cardiovascular system, and neuropsychology. [2][3][4] The treatment-related late effects may further lead to premature aging and death. 5 Telomere length has been shown to correlate with subject's age, [6][7][8] and it is thus hypothesized to be a biomarker of human aging.…”

Section: Introductionmentioning

confidence: 99%

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Telomere length regulators are activated in young men after pediatric kidney transplantation compared to healthy controls and survivors of childhood cancer—A cross‐sectional study

Endén

Tainio

Hou

et al. 2019

Pediatric Transplantation

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Chronic diseases are known to cause premature aging and frailty. Data about telomere length and telomere length‐regulating proteins after pediatric KTx are scarce. Leukocyte telomere length and gene expression level of eight telomere‐binding proteins were analyzed in 20 KTx recipients, eight childhood NBL survivors, and nine healthy controls. The influence of key clinical parameters on telomere length and on regulators of telomere length was evaluated. The telomere length in the KTx recipients tended to be shorter (0.53 AU) than in the healthy controls (0.64 AU) but longer than in the NBL survivors (0.38 AU). There was no significant difference in telomere length between the NBL survivors and the KTx recipients (P = .110). The gene expression level of telomere length‐preserving protein RPA1 was significantly higher in the KTx recipients than among the NBL survivors or healthy controls, while the expression of TRF2 and the tumor suppressor gene p16 was significantly higher in the KTX recipients when compared to the controls. TRF2 and TIN2 correlated significantly with hsCRP; additionally, TRF2 showed significant correlation with plasma creatinine and eGFR. KTx recipients have near to normal telomere length, but they have significantly higher gene expression levels of telomere regulatory proteins compared with healthy controls, suggesting activation of mechanisms preserving telomere length among KTx recipients. Our results suggest that declined graft function and consequent inflammatory response may have influence on telomerase activity.

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Section: Discussionmentioning

confidence: 99%

Section: Study Populationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Telomere length regulators are activated in young men after pediatric kidney transplantation compared to healthy controls and survivors of childhood cancer—A cross‐sectional study

Endén

Tainio

Hou

et al. 2019

Pediatric Transplantation

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“…All solid organ transplantations in Finland are performed and the recipients followed up at the Helsinki University Hospital. The participants for this study were selected as described previously . Briefly, all pediatric male KTx recipients operated between August 1983 and September 2011 were identified from our transplant database.…”

Section: Methodsmentioning

confidence: 99%

“…Tacrolimus was a secondary choice used instead of CsA in the case of recurrent rejections, gradually increasing creatinine, cosmetic problems, or signs of calcineurin inhibitor toxicity. After KTx, MP was dosed daily, switching to alternate‐day dosing at 3–6 months .…”

Section: Methodsmentioning

confidence: 99%

Lower quality of life in young men after pediatric kidney transplantation when compared to healthy controls and survivors of childhood leukemia-a cross-sectional study

et al. 2017

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Data about health-related quality of life (HRQOL) in adult recipients after pediatric kidney transplantation (KTx) are scarce. In this nationwide questionnaire-based study, HRQOL and social status in young adult men having undergone KTx during childhood (n = 29) were studied and compared to age- and gender-matched healthy controls (n = 56) and survivors of childhood acute lymphoblastic leukemia (n = 52) comprising controls with another chronic disease of childhood. Altogether 41% of the KTx recipients, 50% of the leukemia survivors and 80% of the healthy controls lived in a permanent relationship. When compared with leukemia survivors, the KTx recipients reported significantly more bodily pain and worse general health (RAND-36). Older age at time of study, longer duration of dialysis, multiple transplantations and diminished graft function correlated with lower scores. The KTx recipients had a significantly higher mean Beck Depression Inventory (BDI) score than the leukemia survivors (P = 0.000) or the healthy controls (P = 0.006). BDI scores were highest in patients who lived without a partner or children had lower educational level or were unemployed. KTx recipients had significantly lower HRQOL scores than their healthy and controls with childhood chronic disease. Early detection of psychosocial problems and poor physical functioning among these patients is warranted.

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Transplanted Adipose‐Derived Stem Cells Ameliorate Testicular Dysfunction In A D‐Galactose–Induced Aging Rat Model

Yang

Wang

et al. 2015

Journal Cellular Physiology

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Glycation product accumulation during aging of slowly renewing tissues may be an important mechanism underlying aging of the testis. Adipose-derived stem cells (ADSCs) have shown promise in a novel tissue regenerative technique and may have utility in treating sexual dysfunction. ADSCs have also been found to be effective in antiaging therapy, although the mechanism underlying their effects remains unknown. This study was designed to investigate the anti-aging effect of ADSCs in a D-galactose (D-gal)-induced aging animal model and to clarify the underlying mechanism. Randomly selected 6-week-old male Sprague-Dawley rats were subcutaneously injected with D-gal daily for 8 weeks. Two weeks after completion of treatment, D-gal-induced aging rats were randomized to receive caudal vein injections of 3 × 10(6) 5-bromo 2'deoxy-uridine-labeled ADSCs or an equal volume of phosphate-buffered saline. Serum testosterone level, steroidogenic enzymes (3-β-hydroxysteroid dehydrogenase), and superoxide dismutase (SOD) activity decreased significantly in aging rats compared with the control group; serum lipid peroxidation, spermatogenic cell apoptosis, and methane dicarboxylic aldehyde (MDA) expression increased significantly. ADSCs increased the SOD level and reduced the MDA level in the aging animal model and restored levels of serum testosterone, steroidogenic enzymes, and spermatogenic cell apoptosis. These results demonstrate that ADSCs can contribute to testicular regeneration during aging. ADSCs also provide functional benefits through glycation suppression and antioxidant effects in a rat model of aging. Although some ADSCs differentiated into Leydig cells, the paracrine pathway seems to play a main role in this process, resulting in the reduction of apoptosis.

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Testicular Function, Semen Quality, and Fertility in Young Men After Renal Transplantation During Childhood or Adolescence

Abstract: Testicular function is often impaired even years after transplantation and poor semen quality decreases the prospect of fertility in men after pediatric RTx.

Cited by 28 publications

References 35 publications

Telomere length regulators are activated in young men after pediatric kidney transplantation compared to healthy controls and survivors of childhood cancer—A cross‐sectional study

Telomere length regulators are activated in young men after pediatric kidney transplantation compared to healthy controls and survivors of childhood cancer—A cross‐sectional study

Lower quality of life in young men after pediatric kidney transplantation when compared to healthy controls and survivors of childhood leukemia-a cross-sectional study

Transplanted Adipose‐Derived Stem Cells Ameliorate Testicular Dysfunction In A D‐Galactose–Induced Aging Rat Model

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