2022
DOI: 10.21203/rs.3.rs-1643832/v1
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Testicular Histone Hyperacetylation in Mice by Valproic Acid Administration Affects the Next Generation by Changes in Sperm DNA Methylation

Abstract: Various reports have described epigenetic transgenerational inheritance through sperm. However, the detailed mechanism remains unclear. In this study, we focused on DNA methylation and analyzed the effects on the next generation of sperm from mice treated with valproic acid (VPA) as an inducer of epigenomic changes. Administration of 200 mg/kg/day VPA to mice for 4 weeks caused transient histone hyperacetylation in the testes and DNA methylation changes in sperm, including promoter CpGs of genes related to bra… Show more

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