We report a case of a 48‐year‐old man with testicular infarction caused by epididymo‐orchitis (EO). Multimodal ultrasound showed extensive necrosis of the testis, and the patient underwent right orchiectomy. Postoperative pathology confirmed extensive necrosis of the testis. After 3 months of follow‐up, the examination of scrotal ultrasound showed that the left testis and epididymis had no obvious abnormality.