Testicular lesions of coprine and benzcoprine

Jönsson, Malin; Lindquist, Nils Gunnar; Plöen, L.; Ekvärn, Sven; Kronevi, Tony

doi:10.1016/0300-483x(79)90035-0

Cited by 18 publications

(6 citation statements)

References 11 publications

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“…The-observation of the wide range of alterations from severely damaged to apparently unaffected tubules agrees with the results found by PLOEN (1973 a, b). They are also found in other conditions of impaired spermatogenesis (JONSSON et al, 1979;PLOEN, unpublished observations). Although the Sertoli cells were morphologically unaltered in all the boars, this does not exclude functional alterations.…”

Section: Discussionmentioning

confidence: 66%

Experimentally Induced Testicular Alterations in Boars

Malmgren

Larsson

1989

Journal of Veterinary Medicine Series A

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Summary Nine mature boars (8 experimental and one control) were used to study the effects of elevated testicular temperature. The scrotum was covered by a textile‐aluminium foil insulation for 100 hours. The boars were divided into 4 groups and were slaughtered at the end of scrotal insulation (group I), 10 days (group II), 20 days (group III) and 40 days (group IV) after scrotal insulation. In groups I and II changes were seen among primary spermatocytes and spermatids, although the changes in group II were more severe. In group III the changes were restricted to the spermatids and in group IV most of the tubules were normal. The epididymal spermatozoa showed slight changes in group I, severe changes in groups II and III and were normal in group IV. The results indicated that spermatogonia were not affected, whereas primary spermatocytes seemed to be the most susceptible germ cell type. Scrotal insulation produced restricted damage that was reversible when the insulation was removed and turned out to be a suitable method to study regeneration processes in the testis of boars. Zusammenfassung Experimentell induzierte Hoden Veränderungen beim Eber Histologische und ultrastrukturelle Befunde: An neun adulten Ebern (8 Versuchs‐Eber, ein Kontroll‐Eber) wurden die Auswirkungen einer erhöhten Hodentemperatur untersucht. Das Scrotum wurde dabei für 100 Stunden mit mehreren Schichten aus Tuch und Aluminiumfolie isoliert. Die betreffenden Eber wurden in 4 Gruppen eingeteilt und unmittelbar nach der Isolierung des Scrotums (Gruppe I) bzw. 10 Tage (Gruppe II), 20 Tage (Gruppe III) und 40 Tage (Gruppe IV) später geschlachtet. Bei Gruppe I und II waren die primären Spermatozyten und die Spermatiden verändert, wobei die Veränderungen bei Gruppe II ausgeprägter waren. Bei Gruppe III waren die Veränderungen auf die Spermatiden beschränkt, während bei Gruppe IV die meisten Tubuli normal waren. Die Spermatozoen im Nebenhoden zeigten bei Gruppe I leichte Veränderungen, bei Gruppe II und III schwere Veränderungen und bei Gruppe IV normale Verhältnisse. Die Ergebnisse deuten darauf hin, daß die Spermatogonien unverändert waren, wogegen der primäre Spermatozyt der empfindlichste Keimzelltyp zu sein schien. Die Isolierung des Scrotums verursachte somit beschränkte Schädigungen, die nach Entfernung der Isolierung reversibel waren, und erwies sich als brauchbare Methode zur Untersuchung der Regenerationsprozesse im Hoden des Ebers.

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Section: Discussionmentioning

confidence: 66%

Experimentally Induced Testicular Alterations in Boars

Malmgren

Larsson

1989

Journal of Veterinary Medicine Series A

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“…6 The intensity of the disulfi ramlike reaction depends on several factors including the dose of coprine, the amount of ethanol consumed, individual sensitivity, and the time between Coprinus atramentarius ingestion and ethanol consumption. 6 The intensity of the disulfi ramlike reaction depends on several factors including the dose of coprine, the amount of ethanol consumed, individual sensitivity, and the time between Coprinus atramentarius ingestion and ethanol consumption.…”

Section: Dose Responsementioning

confidence: 99%

“…This reaction yields a highly reactive species, possibly a cyclopropyliminium intermediate, which interacts with aldehyde dehydrogenase to block the oxidation of acetaldehyde. 6 However, there are no well documented reports of chronic toxicity resulting from the ingestion of Coprinus atramentarius . 12 Consequently, 1 -aminocyclopropanol is probably the toxic metabolite of coprine.…”

Section: Toxicokineticsmentioning

confidence: 99%

Inky Cap and Coprine Toxicity [Coprinus atramentarius(Bull.) Fr.]

Barceloux

2008

Medical Toxicology of Natural Substances

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“…Anti-neoplastic drugs affect spermatogenesis because they kill rapidly dividing cells. Other compunds, acting directly on the germ cells are alkylating agents, such as ethylene dibromide (used as pesticides or fumigants) and benzcoprine and coprine (Jonsson et al 1979).…”

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confidence: 99%

Spermatogenesis ‐ A Clinical Approach

Malmgren¹

1998

Reprod Domestic Animals

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A well functional spermatogenesis is essential for fertilizing capacity, i.e sperm production must be satisfactory and the spermatozoa produced must have a good quality.Sperm morphology and fertility Evidence of a relationship between sperm morphology and fertility in bulls was desribed by Lagerlof, as early as in 1934. Based on the findings, he stated that the incidence of sperm abnormalities in semen was correlated to the histopathological changes found in the testes in bulls with low fertility .Several studies on fertility in domestic animals have shown that when the proportion of abnormal spermatozoa in the ejaculate increases beyond physiological limits, a decrease in fertility can be expected (Bielanski, 195 1 ; Rao, 197 1 ;Malmgren and Larsson, 1984; Chevalier-Clement et al. 1991). Soderquist and coworkers (1991) found a negative correlation beween abnormal spermatozoa assessed in fresh semen and fertility (56-day NR rate) in frozen semen, even if none of the sperm morphology categories exceeded 4%. They suggested that a correlation between sperm morphology and fertility would most likely not have been detected if the bulls had been used for natural service, as the incidence of abnormal spermatozoa was probably mainly an indication of other associated and more deliterious changes in sperm viability. In general, the results from studies trying to relate sperm morphology to fertility are conflicting, due to influence from other factors, such as difference in the number of females mated and management. Low fertility after use of semen of poor quality raises the questions whether males with a large number of of abnormal spermatozoa in their ejaculates have lowered fertility because the spermatozoa are unable to penetrate the eggs, or because the spermatozoa do not reach the site of fertilization in adequate numbers. Malmgren and Larsson (1984) inseminated gilts with semen of good and poor quality and compared the number of fertilized ova. The small number of spermatozoa attached to the zona pellucida of ova from the gilts inseminated with poor semen indicated that the concentration of fertile spermatozoa in the oviducts was low. Further, Larsson (1988; heifer) suggested that abnormal spermatozoa are unable to reach the site of fertilization in adequate numbers, caused by a slection mechanism in the UTJ (utero-tubaljunction). Sacke and coworkers (1 988) found that the proportion of spermatozoa with normal head morphology attached to the ova, was higher than for spematozoa in the inseminate. It seems as sperm motility also is of great importance in order for the spermatozoa to reach the ova. Only a small number of spermatozoa were recovered from the UTJ and the oviducts in heifers inseminated with immotile spermatozoa (Larsson,

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Testicular lesions of coprine and benzcoprine

Cited by 18 publications

References 11 publications

Experimentally Induced Testicular Alterations in Boars

Experimentally Induced Testicular Alterations in Boars

Inky Cap and Coprine Toxicity [Coprinus atramentarius(Bull.) Fr.]

Spermatogenesis ‐ A Clinical Approach

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