Testicular lymphoma is associated with a high incidence of extranodal recurrence

Testicular lymphoma A Retrospective, Population-based, Clinical and Immunohistochemical Study

“…The choice of further treatment is still a matter of debate, owing to the rare incidence of the disease and the absence of prospective, randomized studies. Systemic, doxorubicin-based chemotherapy has been widely used also in patients with localized disease, since early retrospective reports indicated an improved outcome by adding chemotherapy to surgery9/RT (2 Á/4), but in two recently published, retrospective studies no such benefit was noted (17,18). However, in a very large, retrospective, multicentre study (19), Zucca et al reported a survival benefit for patients treated with anthracycline-containing chemotherapy, regardless of disease stage, and a better outcome for patients who had received at least six cycles of chemotherapy.…”

“…However, this phenomenon has also been recognized in some earlier reports (19,22), in contrast with nodal DLBCL in which such late relapses are rare. Additionally, the CNS relapses in stage Pe I/II testicular lymphoma patients most often affect the brain parenchyma (17,19) whereas the lepto-meninges and brain parenchyma seem to be affected equally often in stage IV patients (19). Also in the present series of Pe stage I patients, 3 CNS relapses occurred in the brain parenchyma (2 of which were isolated in the CNS), one in the leptomeninges and one in both tissues (isolated).…”

Malignant lymphoma of the testis: a study of 12 cases

“…4 Due to the small number of cases of primary testicular lymphoma, there are few prospective treatment trials. 2,8 Retrospective studies report treatment with orchiectomy, various forms of chemotherapy and/or radiation, 3,6,7,[9][10][11][12][13][14] with some cases including prophylactic radiation and/or intrathecal chemotherapy. Testicular lymphoma shows a propensity towards systemic dissemination and relapse even years after complete response (CR) to treatment.…”

“…Testicular lymphoma shows a propensity towards systemic dissemination and relapse even years after complete response (CR) to treatment. 1,14,15 Extranodal and central nervous system (CNS) relapse is common. 15,16 The goal of this study was to review the cases of testicular lymphoma diagnosed at our institution to add to the current knowledge of the presentation, workup, treatment and outcome of this disease, and to determine if there was a significant difference in survival by stage and International Prognostic Index (IPI) score.…”

Orbital Infiltration as the First Site of Relapse of Primary Testicular T-cell Lymphoma

“…Fonseca et al reported an 80% recurrence rate of primary testicular lymphoma after systemic chemotherapy and of the recurrent cases, 32% involved the CNS (7). They insisted that intrathecal prophylactic chemotherapy was not effective because most of the case of CNS recurrence involved the brain parenchyma (7). Though the leptomeningeal recurrence pattern seen in our patient was a rare pattern for testicular lymphoma, any methods of CNS prophylaxis such as irradiation or intrathecal chemotherapy should be considered at the moment of discovering ocular involvement.…”