Testicular plasmacytoma with bone dissemination without medullary plasmacytosis

Abstract

A 34-year-old man was diagnosed as having solitary testicular plasmacytoma. He had received palliative radiotherapy, several combined chemotherapies including CHOP chemotherapy (vincristine, cyclophosphamide, Adriamycin, and prednisone), MP (melphalan and prednisone) and M-2 protocol (melphalan, prednisone, vincristine, carmustine, and cyclophosphamide), and interferon therapy as 3 million units subcutaneous injection three times a week for 1 year. Extensive bone plasmacytoma developed 7 years later without bone marrow involvement. We suggest that early use of combined chemoradiotherapy and high-dose chemotherapy with autologous stem cell support should be investigated in patients with testicular plasmacytoma with dissemination.

Primary plasmacytoma of the testicle: a case report

“…The vast majority of patients with testicular plasmacytoma either have disseminated disease at the time of diagnosis, or develop disseminated disease later in life [1,2,5]. This case is therefore unusual due to the primary nature of the plasmacytoma within the testis.…”

“…On microscopic examination, the tumor appears as sheets of atypical plasma cells with varying degrees of differentiation [5]. Plasmacytomas can be mistaken for other types of tumors, including seminoma, lymphoma and metastatic melanoma [2,4]. In order to make accurate diagnosis, immunologic staining for CD 138, CD 79a and monoclonal antibody VS 38 can be used [4].…”

“…Cases of isolated testicular plasmacytoma are extraordinarily rare, with few cases reported in the literature to date [4]. These patients have a high rate of progression to disseminated disease, and they require close monitoring after appropriate treatment [1,2,5]. We discuss a case of isolated testicular plasmacytoma in a 72-year-old patient with ensuing progression to multiple myeloma.…”

Testicular Plasmacytoma as Initial Presentation of Multiple Myeloma

“…Plasmacytomas can be mistaken for other types of tumors, including seminoma, lymphoma and metastatic melanoma [10], [19] . In order to make accurate diagnosis, immunologic staining for CD 138, CD 79a and monoclonal antibody VS 38 can be used [4] .…”

Testicular Plasmacytoma: Case Report

“…8 Although very unusual, cases of solitary testicular plasmacytoma without evidence of systemic myeloma have been reported. 2,10 Hou et al 10 reviewed the outcome of 15 patients with primary testicular plasmacytoma. Except one patient, progression to myeloma or dissemination was not observed.…”