2013
DOI: 10.1002/pbc.24607
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Testicular sex cord stromal tumors: Analysis of patients from the MAKEI study

Abstract: Diagnosis and therapy of testicular tumors should be planned in accordance with the recommendations of the respective childhood germ cell tumor protocols. High inguinal orchiectomy is safe and constitutes definitive therapy. Diagnostic work-up and follow-up should also consider potentially associated tumor predisposition syndromes.

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Cited by 39 publications
(39 citation statements)
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“…[5][6][7][8][9][10][11][12] We have encountered patterns and cytologic features that have not been described in the literature or only to a minimal degree, which may potentially cause confusion with other neoplasms, most often yolk sac tumor (YST) or, rarely, other sex cord stromal tumors. 13,14 We therefore undertook a comprehensive morphological analysis of testicular JGCT to highlight not only the classic features but also unusual aspects and those useful in differentiating it from other neoplasms.…”
Section: Discussionmentioning
confidence: 99%
“…[5][6][7][8][9][10][11][12] We have encountered patterns and cytologic features that have not been described in the literature or only to a minimal degree, which may potentially cause confusion with other neoplasms, most often yolk sac tumor (YST) or, rarely, other sex cord stromal tumors. 13,14 We therefore undertook a comprehensive morphological analysis of testicular JGCT to highlight not only the classic features but also unusual aspects and those useful in differentiating it from other neoplasms.…”
Section: Discussionmentioning
confidence: 99%
“…Au diagnostic, les TCS testiculaires de l'enfant sont quasiment toujours localisées. Aucun cas de métastases ganglionnaires ou hématogènes n'a été identifié dans les séries françaises (TGM-95), allemandes et italiennes [8,9]. Cependant, chez l'adolescent, du fait d'un risque accru de dissémination locorégionale ou métastatique, le bilan d'extension devra comporter un scanner abdominopelvien, en préopératoire si une tumeur agressive est suspectée ou en post-opératoire après confirmation histologique.…”
Section: Bilan Diagnostiqueunclassified
“…Dans les séries allemandes et italiennes, aucun malade ne se présentait avec une maladie métastatique ou des critères histologiques d'agressivité [8,9]. Néanmoins, la chirurgie doit respecter les recommandations, en particulier la voie d'abord inguinale et le caractère radical de l'orchidectomie sauf dans le cas particulier des petites tumeurs intra-testiculaires accessibles à un traitement conservateur par orchidectomie partielle.…”
Section: Pronostic Et Surveillanceunclassified
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“…3 Numa série de 43 doentes com tumor do testículo na pré-puberdade, apenas um doente com tumor dos cordões sexuais indiferenciado do testículo apresentou metastização, vindo a morrer, apesar da realização de quimioterapia. 6 A determinação da história natural e de fatores de prognóstico do TCSNCT não é fácil uma vez que são muito raros e a taxa de metastização é baixa. Nos tumores dos cordões sexuais, a malignidade está associada a maior volume tumoral e idade avançada, sugerindo que a progressão para a malignidade ocorre com o tempo.…”
unclassified