Testicular torsion and its effects on the spermatogenic cycle in the                contralateral testis of the rat

Vigueras, Rosa María; Reyes, Gilberto Lázaro Betancourt; Rojas-Castañeda, Julio César; Rojas, P.; Hernández, Rocío Alcántara

doi:10.1258/002367704323133709

Cited by 28 publications

(26 citation statements)

References 27 publications

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“…Torsion of the spermatic cord causes strangulation of gonadal blood supply with subsequent testicular necrosis and atrophy, and results in diminished fertility in experimental animals. 12,13 Burdizzo castration has been shown to have no effects on most of feedlot performance traits and blood metabolites. 14 Higher peak cortisol concentration following surgical and banding castration was earlier observed.…”

Section: Introductionmentioning

confidence: 99%

Comparison in haematological and biochemical changes in normal, acute and chronically castrated West African Dwarf goats

Olaifa

2018

Int J Res Med Sci

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Background: Castration is one of the frequent management practices in large animal husbandry and burdizzo castration has been shown to produce fewer long-term behavioral signs of pain and distress than banding. Castration is known to reduce virility and aggression due to the elimination of testicular androgens. Methods: This is a comparative study of hematological and biochemical parameters in intact, acute and chronically castrated West African dwarf goats. Twelve adult West African Dwarf bucks weighing between 8 to 14 kg randomly divided into 3 groups of intact, acute and chronic castrated. They were castrated using burdizzo castrator. Hematological and biochemical parameters were estimated by standard laboratory procedures. Results: There were significant decreases (P<0.05) in the PCV, Hb, RBC, WBC and MCH of acute and chronically castrated goat compared to the control group. The MCV and platelets increased significantly in acute and chronically castrated goat; while the neutrophil and lymphocyte showed no significant changes. The result also showed no significant changes in Na , AST and Creatinine. Mg 2+ and ALT significantly increased in chronically castrated goats compared with the acutely castrated goats while Zinc increased significantly (P<0.05) in acute castrated compared with the control goats. Conclusions: Therefore, from this study, either acute or chronic castration in goats have no detrimental effect on blood electrolytes, but mainly deter the hematopoietic process in the animal owing to testosterone and androgen depletion in castrate animals.

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Section: Introductionmentioning

confidence: 99%

Comparison in haematological and biochemical changes in normal, acute and chronically castrated West African Dwarf goats

Olaifa

2018

Int J Res Med Sci

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“…Besides the severe pain, the occurring ischemia has influence on the spermatogenesis and furthermore, the injury of the blood-testis barrier can provoke immune processes leading to contralateral injury [12,16,23,31,33]. Concerning the microcirculatory alterations there are numerous literature data with various length of ischemia-reperfusion [7,15,16,27,30].…”

Section: Introductionmentioning

confidence: 99%

Testicular ischemia-reperfusion may alter micro-rheological parameters in laboratory rats

Németh

Kiss

Klarik

et al. 2014

Clinical Hemorheology and Microcirculation

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Ischemia-reperfusion-caused hemorheological alterations have been widely studied but the effect of testicular ischemia-reperfusion has not so far. In this study 14 Sprague-Dawley rats were involved. In the ischemia-reperfusion group under general anaesthesia the left testis was explored by opening the scrotum then the deferent duct and vasculature were clamped for 30 minutes. Testicular microcirculation was monitored by laser Doppler flowmetry. The right testis was untouched. In the control group: only anaesthesia was induced. Blood sampling occurred before and after ischemia, at the 60th minute of reperfusion and on the 1st postoperative day for determining hematological parameters (microcell-counter), erythrocyte deformability (slit-flow ektacytometer) and erythrocyte aggregation (light-transmission aggregometer). After the last blood sampling, testicles were removed for histological examination. Hematological parameter changes reflected inflammatory response. Erythrocyte deformability showed a worsening already at the 60th minute of reperfusion compared to base and control values. By the 1st postoperative day further decrease was observed. Erythrocyte aggregation significantly enhanced with great magnitude versus base and control values (p < 0.001). However, conventional histological examinations did not show marked testicular injury. The experienced changes can attract attention to the testicular ischemia-reperfusion causing significant effects on hemorheological parameters, which can lead to further harmful microcirculatory consequences.

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“…There are few experimental studies in the literature in regard to the long-term effects of testicular torsion on the spermatogenesis of the contralateral testis, and the value of the orchiepididymectomy of the twisted testis to prevent them [10][11][12][13][14][15] . Using unilateral testicular torsion of 720 degrees in adult rats for one, two or four hours, Turner 10 observed no injury to the contralateral spermatogenesis testis after seven, 30 and 60 days, evaluating its testis weight, spermatogenesis status only subjectively classified as normal or abnormal and the concentration and motility of the spermatozoids in the tail of the epididymis.…”

Section: Discussionmentioning

confidence: 99%

“…However, there are few and conflicting results in the literature as to whether the testicular torsion causes permanent damage (long-term effects) to the spermatogenesis of the contralateral testis, and whether the orchiepididymectomy of the twisted testis could prevent this damage [10][11][12][13][14][15] . Many theories have been suggested to explain the contralateral injuries to the spermatogenesis, such as auto-immunization induced by the necrotic haploid germ cells of the twisted testis 16 , production of reactive oxygen species 11,14 and contralateral sympathetic reflex 13 .…”

Section: Introductionmentioning

confidence: 99%

Long-term effects of the testicular torsion on the spermatogenesis of the contralateral testis and the preventive value of the twisted testis orchiepididymectomy

Lorenzini

Filho

Gomes³

et al. 2012

Acta Cir. Bras.

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-ORIGINAL ARTICLE EXPERIMENTAL UROLOGYLong-term effects of the testicular torsion on the spermatogenesis of the contralateral testis and the preventive value of the twisted testis orchiepididymectomy 1 Efeitos tardios da torção testicular sobre a espermatogênese do testículo contralateral e o valor preventivo da orquiepididimectomia do testículo torcido ABSTRACT PURPOSE: To determine whether the testicular torsion causes long-term effects on the spermatogenesis of the contralateral testis, and whether the orchiepididymectomy of the twisted testis could prevent them, using specific spermatogenesis parameters to elucidate the conflicting results in the literature. METHODS: Seventy-four pubertal male Wistar rats were randomly selected. The experimental group consisted of 40 rats, divided into four subgroups, submitted to 1.080 degrees counterclockwise left testicular torsion and its scrotal fixation at the beginning of the experiment, and left orchiepididymectomy at one, five, ten and 90 days, respectively. The control group consisted of 24 rats, divided into four sham operation control subgroups. An additional control subgroup consisted of the ten remaining rats, submitted only to the left orchiepididymectomy at the beginning. At 90 days, the contralateral testes of the experimental and control subgroups were collected for the evaluation of their spermatogenesis parameters: testicular weight, seminiferous tubular diameter, Johnsen score and differential counting of the germ cells. RESULTS:No statistically significant differences were observed among the experimental and control subgroups for all of the spermatogenesis parameters of the contralateral testes. CONCLUSIONS: Testicular torsion does not cause long-term effects on the spermatogenesis of the contralateral testis in pubertal rats, and the orchiepididymectomy of the twisted testis is not necessary for preventive purposes for the contralateral spermatogenesis. Key words: Spermatic Cord Torsion. Spermatogenesis. Testis. Rats. RESUMO OBJETIVO:Determinar se a torção testicular causa efeitos tardios sobre a espermatogênese do testículo contralateral e se a orquiepididimectomia do testículo torcido poderia preveni-los, usando parâmetros específicos da espermatogênese para elucidar os resultados conflitantes na literatura. MÉTODOS: Foram selecionados aleatoriamente 74 ratos machos púberes da linhagem Wistar. O grupo experimental foi composto por 40 ratos divididos em quatro subgrupos, submetidos à torção anti-horária de 1,080 graus do testículo esquerdo e sua fixação escrotal no início do experimento e à orquiepidimectomia esquerda com um, cinco, dez e 90 dias, respectivamente. O grupo controle foi composto por 24 ratos divididos em quatro subgrupos de cirurgias simuladas. Um subgrupo controle adicional foi constituído pelos dez ratos restantes submetidos unicamente à orquiepididimectomia esquerda no início do experimento. Aos 90 dias, os testículos contralaterais dos subgrupos experimentais e controles foram coletados para avaliação dos parâmetros de suas espermat...

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Testicular torsion and its effects on the spermatogenic cycle in the contralateral testis of the rat

Cited by 28 publications

References 27 publications

Comparison in haematological and biochemical changes in normal, acute and chronically castrated West African Dwarf goats

Comparison in haematological and biochemical changes in normal, acute and chronically castrated West African Dwarf goats

Testicular ischemia-reperfusion may alter micro-rheological parameters in laboratory rats

Long-term effects of the testicular torsion on the spermatogenesis of the contralateral testis and the preventive value of the twisted testis orchiepididymectomy

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