Testicular Torsion and Spermatogenesis

Flannigan, Ryan; Hayden, Russell; Goldstein, Marc; Li, Philip S.; Lee, Richard K.

doi:10.1007/978-3-030-77779-1_14

Cited by 10 publications

(6 citation statements)

References 133 publications

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“…In the absence of urgent treatment, the occurrence of permanent tissue damage is probable. 18 Another important part of the process of tissue damage due to TT is extensive inflammation of the testicular tissue. Inflammation leads to testicular dysfunction and death due to apoptosis of the spermatogenic lineage.…”

Section: Discussionmentioning

confidence: 99%

“…In this era, a high percentage of reactive oxygen specious is produced and accumulates within the tissue, leading to testicular dysfunction, including low spermatogenesis rate and reduced Tes production. In the absence of urgent treatment, the occurrence of permanent tissue damage is probable 18 . Another important part of the process of tissue damage due to TT is extensive inflammation of the testicular tissue.…”

Section: Discussionmentioning

confidence: 99%

“…In the absence of urgent treatment, the occurrence of permanent tissue damage is probable. 18 Another im- 17 Testicular tissue damage occurs in emergencies such as TT in 2 important cases: damage to spermatogenic lineage cells and damage to Leydig cells. 2,19 As we found in this study, damage to spermatogenic lineage cells leads to a decrease in spermatogenesis with abnormal sperm production.…”

Section: Apoptotic Gene Expressionmentioning

confidence: 99%

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Single intratesticular injection of blood‐serum‐derived exosomes can potentially alleviate testopathy following testicular torsion

Keivan

Torghabeh

Davoodi

et al. 2022

Anim Models and Exp Med

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The sexual system in men includes the testicles, seminal vesicles, and penis. The most important part of this system is the testicles, which produce sperm and the hormone testosterone. The testicles are located inside the sac and are protected by different layers. The structure of the testicles consists of the intricate tubes that make up sperm. The intermediate layers of the seminiferous tubules are

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Apoptotic Gene Expressionmentioning

confidence: 99%

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Single intratesticular injection of blood‐serum‐derived exosomes can potentially alleviate testopathy following testicular torsion

Keivan

Torghabeh

Davoodi

et al. 2022

Anim Models and Exp Med

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“…I/R injury leads to the production of reactive oxygen species, proinflammatory cytokines, neutrophil recruitment, lipid peroxidation, oxygen deficiency, and cellular death, ultimately increasing the risk of severe infertility [ 1 ]. There is a widespread consensus in the literature that ischemia, I/R injury, and oxidative stress have the most devastating effects on testicular tissue and spermatogenesis [ 3 , 5 , 7 , 9 ]. Numerous studies have been conducted on various agents and treatment methods to reduce the harmful effects of testicular torsion on testicular tissue, but due to significant side effects, none have been widely used [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of acetylsalicylic acid and ultrasound elastography on testicular torsion in rats

SOYTÜRK,

BIÇAKCI,

ASLAN

et al. 2023

Turkish Journal of Medical Sciences

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Background/aim To investigate the effects of acetylsalicylic acid (ASA) and the use of ultrasound elastography on testicular torsion. Materials and methods Herein, 6 equal groups of rats were formed (n: 48): control group, sham group, torsion/detorsion (T/D)-1 h group, T/D-1 h + ASA group, T/D-8 h group, and T/D-8 h + ASA group. Testicular torsion was created by rotating the left testis 720° clockwise. At 30 min before torsion, 100 mg/kg of ASA was injected intraperitoneally. Elastography was performed at 8 and 24 h. After orchiectomy, specimens were collected for histopathological evaluation. Results When comparing the left testicular volume (LV) parameters obtained from the elastography applied at 8 h, significant differences were observed between the following group pairs: the sham and T/D-8 h groups, T/D-1 h and T/D-8 h groups, and T/D-1 h + ASA and T/D-8 h groups (p = 0.004, p = 0.023, and p = 0.026, respectively). The mean LVS (velocity) (stiffness assessment) of the groups was similar at 8 h. When comparing the LV parameters at 24 h, significant differences were found between the T/D-1 h and T/D-8 h groups and between the T/D-8 h and T/D-8 h + ASA groups (p = 0.008 and p = 0.004, respectively). For the LVS mean values at 24 h, significant differences were found between the control and sham groups, sham and T/D-1 h groups, sham and T/D-8 h groups, and sham and T/D-8 h + ASA groups (p = 0.009, p = 0.021, p = 0.027, and p = 0.009, respectively). Histopathological evaluation showed a decrease in the morphological grades and an increase in the mean testicular injury scores in the T/D-1 h + ASA group compared to the T/D-1 h group. The T/D-8 h + ASA group had a higher morphological grade than the T/D-8 h group, whereas their mean testicular injury scores were similar. Conclusion ASA treatment for testicular torsion was shown to be ineffective. Elastography can be a complementary method to Doppler ultrasonography in the diagnosis of testicular torsion and can guide surgeons in their approach to surgery.

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“…Testicular torsion is the most common cause of acute paediatric scrotal disease and it can occur at any age ( 1 ). The torsion duration and degree of twisting of the spermatic cord are the most important factors determining the severity of testicular damage ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

ICA II Alleviates Testicular Torsion Injury by Dampening the Oxidative and Inflammatory Stress

et al. 2022

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Testicular torsion-detorsion is an ischaemia-reperfusion-induced male gonad injury that may lead to male infertility. Oxidative stress plays an important role in the ischaemia-reperfusion injury. Icariside II (ICA II) prevents oxidative stress and has obvious protective effects on spermatogenic function. The present study was aimed to investigate therapeutic potentials of ICA II on testicular torsion. 72 mice were randomly divided into three groups: sham-operated control group (n = 24), testicular ischemia-reperfusion + saline group (n = 24) and testicular ischemia-reperfusion + icariside II treated group (n = 24). Testicular ischemia-reperfusion was induced by the left testis rotated 360 degrees in a clockwise direction for 30 minutes followed by detorsion, the contralateral testis was removed. ICA II in saline (5 mg/kg/day) was administrated by gavage immediately after detorsion. The results demonstrated that ICA II alleviated testicular damage by mitigating spermatogenic cell injury and improving testosterone production in mouse models of testicular torsion. We revealed that ICA II alleviated oxidative stress and apoptosis in the testes, reduced inflammatory infiltration and accelerated angiogenesis. Briefly, ICA II administration ameliorated testicular damage by improving spermatogenic function and testosterone production, which supports its use as a pharmacological treatment of testicular torsion.

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Testicular Torsion and Spermatogenesis

Cited by 10 publications

References 133 publications

Single intratesticular injection of blood‐serum‐derived exosomes can potentially alleviate testopathy following testicular torsion

Single intratesticular injection of blood‐serum‐derived exosomes can potentially alleviate testopathy following testicular torsion

Effects of acetylsalicylic acid and ultrasound elastography on testicular torsion in rats

ICA II Alleviates Testicular Torsion Injury by Dampening the Oxidative and Inflammatory Stress

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