TESTICULAR TOXICITY EFFECTS OF MAGNETIC FIELD EXPOSURE AND PROPHYLACTIC ROLE OF COENZYME Q10 AND l-CARNITINE IN MICE

Ramadan, Laila A.; Abd-Allah, Adel R. A.; Aly, Hamdy A.A.; Saad-El-Din, Aisha A.

doi:10.1016/s1043661802001718

Cited by 76 publications

(49 citation statements)

References 25 publications

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“…According to Ramadan et al (2002), mice exposed to magnetic fields of 50 Hz and 20 mT showed decreased sperm count, motility and daily sperm production, as well as changes in testicular histopathological analysis. Aydin et al (2007) irradiated rats continuously for 1, 2 and 3 months, using EMF of 50 Hz and 27.6 ± 8.6 28.0 ± 13.5 F = 0.8/p = 0.49 Connective tissue cells 5.6 ± 2.2 4.8 ± 3.0 4.6 ± 3.4 7.6 ± 7.5 F = 1.0/p = 0.36 Blood vessels 10.9 ± 4.3 15.4 ± 3.4 12.3 ± 3.6 12.2 ± 9.9 F = 0.9/p = 0.42 Lymphatic space 103.7 ± 19.4 111.9 ± 19.0 124.8 ± 22.1 130.6 ± 53.6 F = 1.1/p = 0.33 Intertubular space 142.5 ± 25.0 158.7 ± 26.8 169.5 ± 24.5 178.6 ± 64.6 F = 1.1/p = 0.34 Figure 3.…”

Section: Discussion Testicular Qualitative Analysismentioning

confidence: 99%

Evaluation of testicular degeneration induced by low‐frequency electromagnetic fields

Tenório

Jimenez

Morais

et al. 2011

J of Applied Toxicology

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The population exposure to electromagnetic fields (EMF) has been growing in recent decades. The generation, distribution and use of electric energy can generate low-frequency electromagnetic fields. The present study investigates the effects of EMF (60 Hz and 1 mT) on spermatogenesis of rats during different periods of maturation. Wistar rats were exposed to EMF from day 13 of gestation to postnatal day 21 or 90 in three daily applications of 30 min. Plasma testosterone concentration was not changed by EMF exposure; however, histopathological and histomorphometrical analyses of the testes showed testicular degeneration in a subset of animals exposed to EMF. The magnitude of the degenerative process varied between those individuals affected, indicating different individual sensitivity to EMF. The main alterations observed through transmission electron microscopy were highly electron-dense mitochondria with loss of their organization and cristae. Exposure to 60 Hz and 1 mT EMF can disturb spermatogenesis and may produce subfertility or infertility.

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Section: Discussion Testicular Qualitative Analysismentioning

confidence: 99%

Evaluation of testicular degeneration induced by low‐frequency electromagnetic fields

Tenório

Jimenez

Morais

et al. 2011

J of Applied Toxicology

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“…16 The use of L-carnitine and its derivatives in therapy has been proposed in recent years for treatment of male infertility, and a number of controlled and uncontrolled human [17][18][19][20][21] and animal [22][23][24][25] studies have been published that indicate possible carnitine application. However, the mechanisms by which carnitines control male fertility are not yet understood.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of L‐carnitine on testicular ischaemia–reperfusion injury in rats

Dökmeci

İnan

Başaran

et al. 2006

Cell Biochemistry & Function

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Testicular torsion is a urological emergency referred to as 'acute scrotum', because inappropriate treatment can lead to male subfertility and infertility. A possible cause of testicular damage is the ischaemia-reperfusion (I/R) injury attributed to oxygen free radicals. L-carnitine, a vitamin-like antioxidant, plays a pivotal role in the maturation of spermatozoa within the reproductive tract. The aim of the present paper was to determine the protective effect of L-carnitine on testicular I/R-induced injury. Thirty-two male rats were divided into 4 groups (n = 8). Testicular torsion was created by rotating the right testis 720 degrees in a clockwise direction. Group 1: sham-operated control; group 2: ischaemia; group 3: I/R; group 4: ischaemia-L-carnitine treatment-reperfusion group. L-carnitine (500 mg kg(-1), intraperitoneally) was administered before 30 min of detorsion in Group 4. After torsion (5 h) and detorsion (5 h), bilateral orchidectomy was performed. The malondialdehyde (MDA) level was evaluated in testes. Histopathologically, Johnsen's spermatogenesis criteria and mean seminiferous tubule diameter (MSTD) measurements were used. Testicular MDA levels were higher in the torsion group compared to the sham-control group (p < 0.05). Detorsion (reperfusion) caused a further increase in MDA levels (p < 0.05). Pretreatment with L-carnitine prevented a further increase in MDA levels (p < 0.05). Histologically, torsion caused some separation among germinal cells in the seminiferous tubules, which became much more prominent in the I/R group but was attenuated with L-carnitine pretreatment. In conclusion, L-carnitine pretreatment may have a protective effect in experimental testicular torsion-detorsion model in rats by its well-known antioxidant potential.

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“…More recently, Ramadan et al [2002] found that exposure of mice to fractionated doses of high oscillating magnetic fields (20 mT) caused a significant decrease in sperm count, motility, and daily sperm production.…”

Section: Introductionmentioning

confidence: 99%

Lack of alterations on meiotic chromosomes and morphological characteristics of male germ cells in mice exposed to a 60 Hz and 2.0 mT magnetic field

Heredia-Rojas

Caballero‐Hernández

Fuente

et al. 2003

Bioelectromagnetics

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The effect of in vivo exposure of mice to a 60 Hz sinusoidal magnetic field (MF) at 2.0 mT on male germ cells was studied. The cytological endpoints measured included meiotic chromosome aberrations in spermatocytes and sperm morphology. Three independent experiments were carried out: (a) animals exposed for 72 h, (b) 10 days/8 h daily, and (c) 72 h exposure to MF plus 5 mg/kg of Mitomycin-C. No statistically significant differences indicative of MF effects were observed between MF exposed and control animals. In addition, an opposite effect between MF exposure and Mitomycin-C treatment in terms of chromosomal aberrations and sperm morphology was observed.

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TESTICULAR TOXICITY EFFECTS OF MAGNETIC FIELD EXPOSURE AND PROPHYLACTIC ROLE OF COENZYME Q10 AND l-CARNITINE IN MICE

Cited by 76 publications

References 25 publications

Evaluation of testicular degeneration induced by low‐frequency electromagnetic fields

Evaluation of testicular degeneration induced by low‐frequency electromagnetic fields

Protective effect of L‐carnitine on testicular ischaemia–reperfusion injury in rats

Lack of alterations on meiotic chromosomes and morphological characteristics of male germ cells in mice exposed to a 60 Hz and 2.0 mT magnetic field

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