Testicular Yolk Sac Tumor and Mature Teratoma: Synchronous Bilateral Occurrence in an Infant

Dong, Shu; Zhao, Linsheng; Pei, Guanghua; Zhang, Yanjun; Wang, Shicheng

doi:10.1016/j.urology.2018.03.025

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…The incidence of prepubertal testicular tumors is low, and the occurrence of synchronous BTGCTs of different pathologic histologic types is exceedingly rare. Table 1 shows 5 previous cases of synchronous BTGCTs of different pathological types (7)(8)(9)(10)(11). Mature teratomas and YSTs are the most common benign and malignant testicular tumors in the pediatric population (12), and they are also common pairs of bilateral testicular tumors that have been reported previously.…”

Section: Discussionmentioning

confidence: 94%

Rare pediatric synchronous bilateral testicular germ cell tumors of different pathological types: a case report

Feng,

Qu,

et al. 2024

Front. Pediatr.

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The occurrence of synchronous bilateral testicular germ cell tumors (BTGCTs) of different pathologic histologic types in pediatric patients is rare. We reported a case of a left testicular yolk sac tumor (YST) combined with a right testicular mature teratoma. Left orchiectomy and right testis-sparing surgery were performed. Retroperitoneal recurrence was noted 6 months after surgery. The patient underwent reoperation for the resection of a retroperitoneal mass, which was pathologically diagnosed as a recurrent YST. A full cycle of chemotherapy was then administered. No tumor metastasis or recurrence has yet been detected. We present this new case, and we review the previous literature on synchronous BTGCTs to explore the clinicopathologic features and summarize the diagnostic and therapeutic experience. Radical orchiectomy, as the standard treatment for YSTs, should be considered with caution in patients with bilateral testicular tumors. Rapid intraoperative frozen pathology provides support for timely surgical planning. In patients with intraoperative frozen pathologic specimens suggestive of benign lesions, testis-sparing surgery is the preferred treatment option.

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Section: Discussionmentioning

confidence: 94%

Rare pediatric synchronous bilateral testicular germ cell tumors of different pathological types: a case report

Feng,

Qu,

et al. 2024

Front. Pediatr.

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“…Only English-language articles were considered. The literature search found only 8 cases of prepubertal synchronous primary BTGCTs, and only 3 cases with testes-specific histologies (8)(9)(10)(11)(12)(13)(14)(15).…”

Section: Case Reportmentioning

confidence: 99%

Infantile synchronous primary bilateral testicular germ cell tumor: a case report and review of the literature

Zhu¹,

Chen²,

Shen³

et al. 2019

Transl. Androl. Urol.

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Testicular tumors are uncommon in adults, accounting for <1% of all cancers, with testicular germ cell tumors (TGCTs) representing the majority (>95%) of reported cases. Adult and prepubertal TGCTs are fundamentally distinct and the latter is extremely rare, representing 1% of all pediatric solid tumors and having an annual incidence rate of 0.5-2/100,000 boys. Bilateral TGCTs (BTGCTs) account for 0.5-5% of all testicular tumors; the majority are metachronous, while the synchronous account for approximately 0.5-1%. A 16-month-old boy was admitted to our Urology Department with a 2-week history of a painless scrotal mass. Ultrasonography revealed a homogeneous hyperechoic solid mass with rich blood supply in the right testis, and no discernable testicular tissue. A well-delineated heterogeneous echo mass was found within the left testis. Contrast-enhanced computed tomography (CT) scan showed a significantly enhanced mass in the right testis and a mildly enhanced mass in the left testis. Serum alpha-fetoprotein (AFP) was 12,567 ng/mL, while β-human chorionic gonadotrophin (HCG) and total testosterone levels were normal. Accordingly, bilateral testicular tumors were the primary consideration. The patient underwent right radical inguinal orchiectomy with high ligation of the spermatic cord and left testicle-sparing surgery.Final pathology confirmed a pure yolk sac tumor (YST) from the right testis and a cystic mature teratoma from the left. The follow-up ultrasonography showed no recurrence, with serum AFP returned to normal by postoperative day 44. Synchronous primary BTGCT with teratoma and YST respectively can occur coincidently and successfully treated by testicle-sparing surgery.

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Bilateral Synchronous Testicular Germ Cell Tumors in Children: Case Report and Review of the Literature

Kebudi

Sezer

Eliçevik

et al. 2020

Urology

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Testicular Yolk Sac Tumor and Mature Teratoma: Synchronous Bilateral Occurrence in an Infant

Cited by 4 publications

References 16 publications

Rare pediatric synchronous bilateral testicular germ cell tumors of different pathological types: a case report

Rare pediatric synchronous bilateral testicular germ cell tumors of different pathological types: a case report

Infantile synchronous primary bilateral testicular germ cell tumor: a case report and review of the literature

Bilateral Synchronous Testicular Germ Cell Tumors in Children: Case Report and Review of the Literature

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