Testiculo-Protective Effect of Stem Bark Extract of Enantia chlorantha on Lead Induced Toxicity in Adult Wistar Rat (Rattus norvergicus)

LC, Oyewopo AO Saalu

doi:10.4172/2161-038x.1000107

Reprod Syst Sex Disord

2012

DOI: 10.4172/2161-038x.1000107

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Testiculo-Protective Effect of Stem Bark Extract of Enantia chlorantha on Lead Induced Toxicity in Adult Wistar Rat (Rattus norvergicus)

Oyewopo AO Saalu LC¹

Abstract: Background: The study was designed to investigate the effect of stem bark aqueous extract of Enantia chlorantha on the sperm parameters and the histo-architecture of the testis of adult Wistar rats treated with lead (IV) oxide.

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Cited by 2 publications

References 7 publications

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Heat-assisted extraction of phenolic-rich bioactive antioxidants from Enantia chlorantha stem bark: multi-objective optimization, integrated process techno-economics and profitability risk assessment

Adeyi

Oke

et al. 2023

SN Appl. Sci.

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This present study investigates the heat-assisted extraction (HAE) of bioactive antioxidants from Enantia chlorantha stem bark (ECSB). The effects of process parameters of operating temperature (OT: 35–55 °C), extraction time (ET: 100–200 min) and solid: liquid ratio (S/L: 1:20–1:50 g/mL) are determined on the total polyphenol content (TPC), antioxidant activity (AA) and extract yield (EY) using the D-Optimal design. Multi-criteria optimization is also conducted to determine the HAE optimum conditions. The integrated process for E. chlorantha stem bark extracts (ECBEs) production is thereafter designed with the optimum HAE conditions and techno-economically analysed. Three industrial ECBEs production setups (5, 100 and 1000 L extractor capacities) are analysed for probable scale-up and the risk & sensitivity analyses are conducted via Monte Carlo simulation. The HAE parameters affect the extraction process significantly. The OT, ET and S/L that maximize the TPC, AA and EY simultaneously are: OT = 54.10 °C, ET = 120.16 min and S/L = 1:50 g/mL. The 1000 L plant extractor setup is the most economical capacity having the least unit production cost (UPC) of 763.52 US$/kg ECBEs. The certainty of achieving 763.52 US$/kg ECBEs for the 1000 L capacity is 55.43% and the only variable with negative contribution (− 37.9%) on ECBEs UPC is the extract recovery variable.

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Heat-assisted extraction of phenolic-rich bioactive antioxidants from Enantia chlorantha stem bark: multi-objective optimization, integrated process techno-economics and profitability risk assessment

Adeyi

Oke

et al. 2023

SN Appl. Sci.

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A Review on Traditionally Used African Medicinal Plant Annickia chlorantha, Its Phytochemistry, and Anticancer Potential

Sarbadhikary

George

2022

Plants

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Annickia chlorantha Setten & P.J.Maas belongs to the Annonaceae family and is a multi-purpose medicinal plant, which has been extensively used for the traditional treatment option for malaria in western and central Africa. Its phytochemical composition is dominated particularly by various biologically active protoberberines and acetogenins. This review aims to provide a comprehensive review on the traditional uses, phytochemical profiles, and the toxicology of this plant from a myriad of available publications. Even after its tremendous applications against several different human ailments, this plant has been underestimated for its anticancer potential. Herein, based on the phytochemical composition, we discuss the probable mode of mechanism for its antiproliferative activity, which highlights its importance for cytotoxicity screenings against cancer cells. Additionally, this article discusses several research questions and suggests the future directions of its applications in medicinal plant-based anticancer research.

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Testiculo-Protective Effect of Stem Bark Extract of Enantia chlorantha on Lead Induced Toxicity in Adult Wistar Rat (Rattus norvergicus)

Abstract: Background: The study was designed to investigate the effect of stem bark aqueous extract of Enantia chlorantha on the sperm parameters and the histo-architecture of the testis of adult Wistar rats treated with lead (IV) oxide.

Cited by 2 publications

References 7 publications

Heat-assisted extraction of phenolic-rich bioactive antioxidants from Enantia chlorantha stem bark: multi-objective optimization, integrated process techno-economics and profitability risk assessment

Heat-assisted extraction of phenolic-rich bioactive antioxidants from Enantia chlorantha stem bark: multi-objective optimization, integrated process techno-economics and profitability risk assessment

A Review on Traditionally Used African Medicinal Plant Annickia chlorantha, Its Phytochemistry, and Anticancer Potential

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