Testing antiplatelet and antioxidant activity of the
extract of seven varieties of <i>Allium cepa</i> L.

Saplonţai-Pop, Aniela; Moţ, Augustin C.; Moldovan, Mărioara; Oprean, Radu; Silaghi-Dumitrescu, Radu; Orășan, Olga Hilda; Pârvu, Marcel; Gál, Emese; Ionescu, Clara M.

doi:10.1515/biol-2015-0011

Cited by 5 publications

(5 citation statements)

References 17 publications

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“…The interaction between inflammation, insulin resistance and atherogenesis represents a pathway for cardiovascular disease development [14,22]. The relationship between insulin resistance and inflammatory status seems to be bidirectional, inflammation leading to insulin resistance and insulin resistance further enhancing the pro-inflammatory state [24,26,31,32]. We found significant differences in the values of adhesion molecules in relation to HOMA quartiles (similarly to Hsu [31]) (for sICAM1 -difference between men and women p=0.038, but just for the upper quartile of HOMA; for sICAM1difference for men between values registered in the upper vs the lower quartile of HOMA p=0.002).…”

Section: Resultsmentioning

confidence: 99%

The Realtionship Between Inflammation and Metabolic Syndrome (MetS)-A Matter of Gender?

Taut¹,

Orășan²,

Fodor³

et al. 2019

Rev. Chim.

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Were investigated the relationship between gender, cardiovascular risk factors and inflammation in metabolic syndrome (MetS) patients. 100 consecutive patients (75 women), 73 with MetS, mean age 57.52�9.77 years, were examined. Adhesion molecules (sICAM1, sVCAM1) were measured in the stored serum samples collected using the ELISA method. The classification of MetS was based on IDF guidelines. The study was carried out at the Department of Cardiology, Clinical Rehabilitation Hospital, Cluj-Napoca, Romania. MetS patients presented lower sICAM1 values (225.01�86.75 ng/mL vs 234.22�82.23 ng/mL, p=NS), but higher sVCAM1 values (605.34�298.69 ng/mL vs 552.29�233.77 ng/mL, p=NS). Differences between patients with vs without metabolic syndrome were found only in men for sICAM1 (194.73�37.92 ng/mL vs 282�27.15 ng/mL, p[0.001). Considering the HOMA index, a significant difference for sICAM1 was found in men (patients within the upper quartile vs the lower quartile, p=0.002), but also between women and men within the upper quartile of HOMA (for sICAM1 p=0.038). No significant differences were found for sVCAM1. In the case of males, sICAM1 was an independent predictor of metabolic syndrome, with a very good capacity to identify metabolic syndrome (AUROC=0.987, p=0.0001, Se=89.47%, Sp=100%). In conclusion, just in men, sICAM1 seems to have an excellent capacity to differentiate between MetS+ and MetS- patients, to predict MetS development.

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Section: Resultsmentioning

confidence: 99%

The Realtionship Between Inflammation and Metabolic Syndrome (MetS)-A Matter of Gender?

Taut¹,

Orășan²,

Fodor³

et al. 2019

Rev. Chim.

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“…Saplonţai-Pop et al reported that A. cepa bulbs have antiplatelet activity. The activity test used platelet-rich plasma (PRP), which is based on the kinetic curve of decreasing plasma OD [ 94 ], while the research conducted by Ko et al used the platelet aggregation turbidometric assay [ 95 ]. Hiyasat et al reported that A. ursinum leaf extract has antiplatelet activity.…”

Section: Allium Species Leave Bioactivity and Test Methodsmentioning

confidence: 99%

Antioxidant Properties and Structure-Antioxidant Activity Relationship of Allium Species Leaves

et al. 2021

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Allium is a genus that is widely consumed and used as traditional medicine in several countries. This genus has two major species, namely cultivated species and wild species. Cultivated species consist of A. cepa L., A. sativum L., A. fistulosum L. and A. schoenoprasum L. and wild species consist of A. ursinum L., A. flavum L., A. scorodoprasum L., A. vineale L. and A. atroviolaceum Boiss. Several studies report that the Allium species contain secondary metabolites such as polyphenols, flavonoids and tannins and have bioactivity such as antioxidants, antibacterial, antifungal, anti-inflammatory, pancreatic α-amylase, glucoamylase enzyme inhibitors and antiplatelets. This review summarizes some information regarding the types of Allium species (ethnobotany and ethnopharmacology), the content of compounds of Allium species leaves with various isolation methods, bioactivities, antioxidant properties and the structure-antioxidant activity relationship (SAR) of Allium compounds.

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“…However, its threshold levels vary widely; the cut-off values of HOMA-IR are usually defined by population-based percentile criteria. Moreover, these cut-off values are different depending on ethnicity, clinical methods of estimation, and metabolic conditions of the studied populations [18,19].…”

Section: Resultsmentioning

confidence: 99%

A comparison between insulin resistance scores parameters in identifying patients with metabolic syndrome

Cozma¹,

Fodor²,

Orășan³

et al. 2019

Studia UBB Chemia

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As a consequence of the epidemic of obesity, prediction of metabolic syndrome (MetS) is relevant because of its subsequent association with type 2 diabetes and cardiovascular disease. Also, MetS is considered a state of insulin resistance (IR). This study aimed to evaluate the capacity of different indirect IR scores to identify patients with MetS, compared to standard criteria of MetS diagnosis. To the best of our knowledge, the cutoff values of these indexes, as indicators of MetS, in the Romanian population, have not been established. We used a non-parametric extension of the induced ROC regression methodology to determine the cutoff values of HOMA-IR, QUICKI, McAuley indexes, taking into account the MetS components instead of using 90th percentile criteria. Although HOMA is more commonly used in practice (probably due to its easy use), McAuley Score seems to have a better specificity in identifying patients with MetS. This is different between men and women; if in women, McAuley index has the highest sensitivity, in men, HOMA and QUICKI indexes have the highest sensitivity and specificity.

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Testing antiplatelet and antioxidant activity of the extract of seven varieties of Allium cepa L.

Cited by 5 publications

References 17 publications

The Realtionship Between Inflammation and Metabolic Syndrome (MetS)-A Matter of Gender?

The Realtionship Between Inflammation and Metabolic Syndrome (MetS)-A Matter of Gender?

Antioxidant Properties and Structure-Antioxidant Activity Relationship of Allium Species Leaves

A comparison between insulin resistance scores parameters in identifying patients with metabolic syndrome

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