Testing Genetic Susceptibility Loci for Alcoholic Heart Muscle Disease

Kajander, Olli A.; Kupari, Markku; Perola, Markus; Pajarinen, Jukka; Savolainen, Vesa; Penttil??, Antti; Karhunen, Pekka J.

doi:10.1097/00000374-200110000-00001

Cited by 3 publications

(3 citation statements)

References 39 publications

(31 reference statements)

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“…The selection of the two polymorphisms investigated in a first study (A-153G and A+39C) was based on the fact that they had been previously suggested to be involved in susceptibility to myocardial infarction and essential hypertension (24). No interactions with daily alcohol use for the various polymorphisms of the renin-angiotensin-aldosterone system were found in a second study (25). These data agree with earlier studies from various countries that showed no associations between either, the ID polymorphism of ACE, or the 1166A/C polymorphism of AGTR1, the LV dimensions and mass at echocardiography.…”

Section: Angiotensin-ii Type 1 Receptor (Agtr1) Genementioning

confidence: 99%

“…Kajander et al reported that the genes that code for alcohol and acetaldehyde dehydrogenases (ADHs and ALDHs) also contain common functional polymorphisms (25). ADH2 has two metabolically faster alleles, 2 and 3, and the ADH2:2 allele has been associated with alcoholic liver cirrhosis.…”

Section: Alcohol and Acetaldehyde Dehydrogenases (Adhs And Aldhs) Genesmentioning

confidence: 99%

“…The gene that codes for the major component of microsomal ethanol oxidation system, cytochrome P-450 2E1 (CYP2E1), also contains several polymorphic sites, of which the PstI and RsaI polymorphisms have been associated with alcoholic liver disease (25). DraI and MspI polymorphisms of CYP2E1 are of unknown functional significance, but DraI polymorphism was linked with the prevalence of alcoholism in one study (25).…”

Section: Cytochrome P-450 2e1 (Cyp2e1)mentioning

confidence: 99%

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Genetic polymorphisms in dilated cardiomyopathy

Stambader

Dorn²,

Mikuz³

et al. 2010

Front Biosci

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Dilated cardiomypathies (DCM) are characterized by dilatation and pump dysfunction of the heart. DCM has an incidence of 6/100.000 people a year contributing to a considerable number of cases of heart failure. Although etiology and pathogenesis are known to be multifactorial, they remain mostly unidentified. Recent research identified patients affected with DCM with altered gene products. These alterations can roughly be grouped into causative genes, mostly coding for cytoskeletal proteins. Other genes seem to be activated after the disease onset and are able to influence the clinical course. In this study we systematically analyzed the role of genetic polymorphisms, based on peer-reviewed articles, published in scientific journals. A total of 97 original studies and a selected number of 60 genes, that seem to be related to DCM, have been reviewed.

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Section: Angiotensin-ii Type 1 Receptor (Agtr1) Genementioning

confidence: 99%

Section: Alcohol and Acetaldehyde Dehydrogenases (Adhs And Aldhs) Genesmentioning

confidence: 99%

Section: Cytochrome P-450 2e1 (Cyp2e1)mentioning

confidence: 99%

See 1 more Smart Citation

Genetic polymorphisms in dilated cardiomyopathy

Stambader

Dorn²,

Mikuz³

et al. 2010

Front Biosci

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Alkoholkonsum bei Frauen und Senioren

Pankuweit

2016

Herz

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The association between alcohol consumption and the etiology and prognosis of cardiovascular diseases has been the focus of attention and also the subject of controversial discussions for many years. This is particularly true for heart failure, which can be induced by coronary artery disease (CAD), arterial hypertension, atrial and ventricular arrhythmias and cardiomyopathies. Acute effects of high doses of alcohol can lead to impairment of the cardiac contraction strength with rhythm disturbances (holiday heart syndrome), transient ischemic attacks and in rare cases to sudden cardiac death. The chronic effects of high alcohol consumption include in particular, ventricular dysfunction, chronic rhythm disturbances, alcoholic cardiomyopathy and CAD. In contrast, light to moderate consumption of alcohol is associated with a reduced risk of CAD and ischemic stroke; however, even moderate alcohol drinking is associated with a greater risk for atrial fibrillation. The unfavorable effects of alcohol occur at much lower levels of acute or chronic consumption in women than in men. In the elderly just as in young people, a moderate alcohol consumption is associated with a lower risk of heart failure.

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Cardiovascular risks and benefits of moderate and heavy alcohol consumption

2015

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The heart and vascular system are susceptible to the harmful effects of alcohol. Alcohol is an active toxin that undergoes widespread diffusion throughout the body, causing multiple synchronous and synergistic effects. Alcohol consumption decreases myocardial contractility and induces arrhythmias and dilated cardiomyopathy, resulting in progressive cardiovascular dysfunction and structural damage. Alcohol, whether at binge doses or a high cumulative lifetime consumption-both of which should be discouraged-is clearly deleterious for the cardiovascular system, increasing the incidence of total and cardiovascular mortality, coronary and peripheral artery disease, heart failure, stroke, hypertension, dyslipidaemia, and diabetes mellitus. However, epidemiological, case-control studies and meta-analyses have shown a U-type bimodal relationship so that low-to-moderate alcohol consumption (particularly of wine or beer) is associated with a decrease in cardiovascular events and mortality, compared with abstention. Potential confounding influences-alcohol-dose quantification, tobacco use, diet, exercise, lifestyle, cancer risk, accidents, and dependence-can affect the results of studies of both low-dose and high-dose alcohol consumption. Mendelian methodological approaches have led to doubts regarding the beneficial cardiovascular effects of alcohol, and the overall balance of beneficial and detrimental effects should be considered when making individual and population-wide recommendations, as reductions in alcohol consumption should provide overall health benefits.

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Testing Genetic Susceptibility Loci for Alcoholic Heart Muscle Disease

Abstract: The gene polymorphisms selected for and analyzed in our study are unlikely to modify the effects of alcohol on the heart. Other unknown factors determine the individual susceptibility to alcoholic heart muscle disease.

Cited by 3 publications

References 39 publications

Genetic polymorphisms in dilated cardiomyopathy

Genetic polymorphisms in dilated cardiomyopathy

Alkoholkonsum bei Frauen und Senioren

Cardiovascular risks and benefits of moderate and heavy alcohol consumption

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