“…The amount of additive transfer from waterpipe tobacco to smoke was not found to be strongly dependent on any single physicochemical property but 39% of the transfer rate variance can be explained collectively by the additive boiling point, molecular weight, vapor pressure and water solubility. Indeed, waterpipe smoking is a complex process, dependent on several parameters e.g., heating source, temperature, charcoal type, number of charcoal pieces used [13] , [5] , user puff profile, waterpipe size/ shape and tobacco composition [1] , [16] , [17] , [2] . Erythropel et al [7] had reported that ‘water solubility probably only plays a minor role for determining the “efficiency” of the filtration step’.…”