Testing of endosulfan and fenitrothion for genotoxicity in Saccharomyces cerevisiae

Yadav, A. S.; Vashishat, Rajni; Kakar, S. N.

doi:10.1016/0165-7992(82)90184-1

Cited by 21 publications

(7 citation statements)

References 10 publications

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“…In mammals, endosulfan affects the central nervous system in which activated metabolites of endosulfan alter and inhibit neurotransmission in the brain (Abalis et al 1986;Gant et al 1987) and activate cholinergic ), dopaminergic (Anand et al 1985), and serotonergic (Agrawal et al 1983;Seth et al 1986) mechanisms. Endosulfan has been implicated in gonadal toxicity (Singh and Pandey 1989;Sinha et al 1997Sinha et al , 2001 and genotoxicity (Yadav et al 1982;Pandey et al 1990;Chaudhuri et al 1999;Lu et al 2000). It is extremely toxic to fishes and aquatic invertebrates (Sunderam et al 1992).…”

mentioning

confidence: 99%

Effects of Endosulfan on Survival and Development of Bombina orientalis (Boulenger) Embryos

Kang

Gye

Kim

2008

Bull Environ Contam Toxicol

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The developmental toxicity of endosulfan was examined in the anuran Bombina orientalis embryos. Survival rates of embryos following 50 microM endosulfan treatment was significantly lower than vehicle control at 96 h onward. When the embryos develop to the tail fin circulation stage, embryonic survival was significantly decreased by 10 microM endosulfan treatment. Surviving embryos showed various developmental abnormalities including tail dysplasia at 50 microM. By hampering the embryonic development endosulfan may cause the decline in the natural populations of this frog species breeding on farmland and in the surrounding aquatic environment.

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mentioning

confidence: 99%

Effects of Endosulfan on Survival and Development of Bombina orientalis (Boulenger) Embryos

Kang

Gye

Kim

2008

Bull Environ Contam Toxicol

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“…Endosulfan induces crossing over, gene conversion, and gene mutation in Saccharomyces cerevisiae [Yadav et al, 1982]. It was, however, nonmutagenic in Salmonella typhimurium at doses up to 5,000 lg/plate [Moriya et al, 1983] and at concentrations of 1 3 10 À4 À 8 3 10 À3 M [Pednekar et al, 1987].…”

Section: Discussionmentioning

confidence: 99%

“…Endosulfan induces chromosomal damage as recessive lethals and sex chromosomal losses in Drosophila melanogaster [Velazquez et al, 1984] as well as reverse mutation and gene conversion in yeast [Yadav et al, 1982]. Accumulation of endosulfan and its potentially mutagenic metabolites because of a specific metabolic and/or DNA-repair pathway in particular cells could influence the amount of DNA damage and mutation produced by endosulfan.…”

Section: Discussionmentioning

confidence: 99%

DNA damage and mutagenicity induced by endosulfan and its metabolites

Bajpayee

Pandey

Zaidi

et al. 2006

Environ and Mol Mutagen

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Endosulfan is a widely used broad-spectrum organochlorine pesticide, which acts as a contact and stomach poison. Nontarget species, such as cattle, fish, birds, and even humans, are also affected. Studies on the genotoxicity and mutagenicity of endosulfan have been inconsistent and nothing is known about the genotoxicity of its metabolites. In the present study, endosulfan (as a commercial isomeric mixture and as the alpha- and beta-isomers), and metabolites of endosulfan (the sulfate, lactone, ether, hydroxyether, and diol derivatives) were assayed for their ability to induce DNA damage in Chinese hamster ovary (CHO) cells and human lymphocytes using the Comet assay and were assayed for their mutagenicity using the Salmonella reversion assay (Ames test with TA98, TA97a, TA102, TA104, and TA100, with and without S9 activation). The compounds produced statistically significant (P < 0.01), concentration-dependent (0.25-10 microM) increases in DNA damage in both CHO cells and human lymphocytes. Endosulfan lactone caused the most DNA damage in CHO cells, while the isomeric mixture of endosulfan produced the greatest response in lymphocytes. The test compounds also were mutagenic in Salmonella strains at concentrations of 1-20 mug/plate (P < 0.05), with TA98 being the most sensitive strain and the diol and hydroxyether metabolites producing the highest responses. The results indicate that exposure to sublethal doses of endosulfan and its metabolites induces DNA damage and mutation. The contribution of the metabolites to the genotoxicity of the parent compound in Salmonella and mammalian cells, however, is unclear, and the pathways leading to bacterial mutation and mammalian cell DNA damage appear to differ.

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“…1.7. Endosulfan Endosulfan was ineffective in the Ames test (Shirasu et al, 1982), but induced both gene convertants and revertants in Saccharomyces cerevisiae (Yadav et al, 1982).…”

Section: Toxaphenementioning

confidence: 94%

Mutagenicity, Carcinogenicity, and Teratogenicity of Industrial Pollutants

Kirsch‐Volders¹

1984

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Testing of endosulfan and fenitrothion for genotoxicity in Saccharomyces cerevisiae

Cited by 21 publications

References 10 publications

Effects of Endosulfan on Survival and Development of Bombina orientalis (Boulenger) Embryos

Effects of Endosulfan on Survival and Development of Bombina orientalis (Boulenger) Embryos

DNA damage and mutagenicity induced by endosulfan and its metabolites

Mutagenicity, Carcinogenicity, and Teratogenicity of Industrial Pollutants

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