Testing of kisspeptin levels in girls with idiopathic central precocious puberty and its significance

Yang, Yu; Xiong, Xiangyu; Yang, Li; Xie, Liangdi; Huang, Hui

doi:10.3892/etm.2015.2398

Cited by 15 publications

(30 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some studies have had different results. The study conducted by Yang et al (2015) demonstrated that plasma kisspeptin levels were higher in ICPP girls, when compared to PT girls and normal controls, but there was no difference between PT and controls. Özgen et al (2016) reported that plasma kisspeptin levels were higher in ICPP girls, when compared to HC girls, but there was no difference between either PT and HC, or ICPP and PT.…”

Section: Discussionmentioning

confidence: 95%

Evaluation of Serum Makorin Ring Finger Protein 3 (MKRN3) Levels in Girls With Idiopathic Central Precocious Puberty and Premature Thelarche

Wang

Shao

et al. 2020

Physiol Res

View full text Add to dashboard Cite

This study aims to investigate serum makorin ring finger protein 3 (MKRN3) levels in girls with idiopathic central precocious puberty (ICPP) and premature thelarche (PT), in order to determine whether circulating MKRN3 level is associated with ICPP and PT. A total of 90 girls were enrolled in the study. 30 age-matched girls were allocated for each group (ICPP, PT and healthy controls [HC], respectively). The base LH (B-LH) and E2 levels were higher in ICPP girls than those in HC and PT girls. The peak LH (P-LH) levels and P-LH/P-FSH values were obviously higher in ICPP girls than those in PT girls, while higher peak FSH (P-FSH) levels were detected in PT girls when compared to those in ICPP girls. Kisspeptin levels were lower in HC girls than those in ICPP and PT girls. MKRN3 levels were the highest in HC girls among the three groups. There were relatively strong negative correlations among MKRN3, kisspeptin and P-LH/P-FSH. Circulating MKRN3 can have an important role in the onset of ICPP and PT. However, this should not be used as an independent diagnostic criterion for diagnosing ICPP or differentiating ICPP from PT, but should be used only as an adjunctive diagnostic biomarker.

show abstract

Section: Discussionmentioning

confidence: 95%

Evaluation of Serum Makorin Ring Finger Protein 3 (MKRN3) Levels in Girls With Idiopathic Central Precocious Puberty and Premature Thelarche

Wang

Shao

et al. 2020

Physiol Res

View full text Add to dashboard Cite

show abstract

“…In both studies, authors suggested that basal kisspeptin level is a useful diagnostic tool in diagnosis of ICPP. Yang et al ( 6 ) reported that kisspeptin levels in ICPP patients were higher than those in patient with PT and in prepubertal controls. After 6 months of treatment with GnRHa, kisspeptin level was lower than that prior to treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Kisspeptin is the most extensively studied neuropeptide in puberty and precocious puberty ( 6 , 7 , 8 ). In human, KISS1 is located on chromosome 1q32 and is detected in brain, pancreas, placenta, testis and genital tract ( 10 ).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, there is a need for a simple method for the differential diagnosis. To date, numerous studies have been published on kisspeptin and/or neurokinin B levels in girls with CPP ( 6 , 7 , 8 ). In these studies, it has been demonstrated that basal serum kisspeptin and/or neurokinin B levels are higher in girls with CPP and PT as compared to healthy controls.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Basal Serum Neurokinin B Levels in Differentiating Idiopathic Central Precocious Puberty from Premature Thelarche

Parlak¹,

Türkkahraman²,

Elli̇dağ³

et al. 2017

Jcrpe

View full text Add to dashboard Cite

Objective:To find out the diagnostic role of kisspeptin and neurokinin B in idiopathic central precocious puberty (ICPP) and premature thelarche (PT).Methods:The girls who presented with early breast development before the age of 8 years were evaluated. Patients with intracranial pathologies were excluded. Basal and stimulated follicle-stimulating hormone/luteinizing hormone (LH) levels and basal neurokinin B/kisspeptin levels were measured. Patients who had peak value of LH >5 mIU/mL and a bone age (BA)/chronological age (CA) ratio >1.1 were diagnosed as central precocious puberty (CPP), while cases who did not meet these criteria were diagnosed as PT. Healthy age-matched prepubertal girls were included as the control group.Results:The study group contained 25 girls with ICPP (7±0.8 years), 35 girls with PT (6.8±0.7 years), and 30 controls (6.7±0.7 years). Basal serum kisspeptin and neurokinin B levels were 2.36±0.47 ng/mL and 2.61±0.32 ng/mL, respectively in the ICPP group, 2.23±0.43 ng/mL and 2.24±0.23 ng/mL, respectively in the PT group, and 1.92±0.33 ng/mL and 2.03±0.24 ng/mL, respectively in the controls. Both kisspeptin and neurokinin B levels were higher in the ICPP and PT groups compared to controls (p<0.05). Moreover, basal neurokinin B level was different between ICPP and PT groups (p<0.01). A serum neurokinin B level of 2.42 ng/mL provided the most appropriate level to differentiate ICPP from PT, with a sensitivity of 84% and specificity of 77.1%.Conclusion:Differentiation of CPP from PT is sometime difficult, and there is a need for a simple method for the differential diagnosis. Our results suggest that basal serum neurokinin B level can be used as an adjunctive parameter to differentiate ICCP from PT.

show abstract

“…In mice, it has been noted that leptin's influence on adipose tissue affects the timing of puberty [5]. It has also been suggested that the plasma level of kisspeptin is associated with the initiation of pubertal development, and kisspeptin may serve as an important factor in the diagnosis of abnormal puberty [6].…”

Section: Introductionmentioning

confidence: 99%

Puberty-Defining Normal and Understanding Abnormal

Silva

Tschirhart

2016

Curr Treat Options Peds

View full text Add to dashboard Cite

Testing of kisspeptin levels in girls with idiopathic central precocious puberty and its significance

Cited by 15 publications

References 12 publications

Evaluation of Serum Makorin Ring Finger Protein 3 (MKRN3) Levels in Girls With Idiopathic Central Precocious Puberty and Premature Thelarche

Evaluation of Serum Makorin Ring Finger Protein 3 (MKRN3) Levels in Girls With Idiopathic Central Precocious Puberty and Premature Thelarche

Basal Serum Neurokinin B Levels in Differentiating Idiopathic Central Precocious Puberty from Premature Thelarche

Puberty-Defining Normal and Understanding Abnormal

Contact Info

Product

Resources

About