Testing of resveratrol microemulsion photostability and protective effect against UV induced oxidative stress

Juškaitė, Vaida; Ramanauskienė, Kristina; Briedis, Vitalis

doi:10.1515/acph-2017-0018

Cited by 20 publications

(7 citation statements)

References 16 publications

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“…↑Cell viability ↓Apoptosis ↑Activation of SIRT1 [87] Cells first treated with 2% of resveratrol for 2 hr, followed by UVB irradiation (5-100 mJ/cm 2 ) ↑Cell viability ND [88] Cells treated with 5-25 μM resveratrol for 24 hr, followed by irradiation with UVB (40 mJ/cm 2 )…”

Section: Anti-uv Irradiationmentioning

confidence: 99%

Role of Resveratrol in Regulating Cutaneous Functions

Wen

Zhang

Yang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Protective role of the skin is against external insults and maintenance of electrolyte homeostasis of the body. Cutaneous dysfunction can account for the development of both cutaneous and systemic disorders. Thus, improvements in cutaneous functions can benefit a number of extracutaneous and cutaneous functions. Resveratrol, a natural ingredient, displays multiple benefits for various systems/organs, including the skin. The benefits of resveratrol for cutaneous functions include stimulation of keratinocyte differentiation and antimicrobial peptide expression, inhibition of keratinocyte proliferation and cutaneous inflammation, UV protection, anticancer, antiaging, and inhibition of melanogenesis. The mechanisms of action of resveratrol include activation of sirtuin 1 and nuclear factor erythroid 2-related factor 2, and inhibition of mitogen-activated protein kinase signaling. Evidence suggests that topical resveratrol could be a valuable alternative not only for daily skin care, but also for the prevention and treatment of various cutaneous disorders. This review summarizes the benefits of resveratrol for cutaneous functions.

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Section: Anti-uv Irradiationmentioning

confidence: 99%

Role of Resveratrol in Regulating Cutaneous Functions

Wen

Zhang

Yang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…Resveratrol is also reported to promote metabolism and reduce oxidative stress, which can also be used as an antioxidant affecting the synthesis of nitric oxide that regulates DNA damage, cell cycle, apoptosis, and proliferation [14]. In addition, a number of studies on resveratrol have revealed possible mechanisms of UV protection, such as inhibiting the activation of NF-κB and preventing the expression of MMP-9 [15,16]. Resveratrol has gradually been found to have potential health benefits, including antiaging, anti-diabetes, anti-cancer, and anti-dementia [17,18].…”

Section: Introductionmentioning

confidence: 99%

The Cytotoxicity Effect of Resveratrol: Cell Cycle Arrest and Induced Apoptosis of Breast Cancer 4T1 Cells

Liang

Zhu

et al. 2019

Toxins

128

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Resveratrol, a natural polyterpenoid, can scavenge reactive oxygen species in vivo to carry out the functions of antioxidation and antiaging. Resveratrol's anti-cancer capability has attracted widespread attention, but its molecular mechanism has not been systematically explained. In this study, by comparing the activity of normal cell lines and cancer cell lines after treating with resveratrol, it was found that resveratrol has more significant cytotoxicity in cancer cell lines. Resveratrol could play a toxic role through inducing apoptosis of the cancer cell in a timeand concentration-dependent manner. A total of 330 significantly differential genes were identified through large-scale transcriptome sequencing, among which 103 genes were upregulated and 227 genes were downregulated. Transcriptome and qRT-PCR data proved that a large number of genes related to cell cycle were differentially expressed after the treatment of resveratrol. The changes of cell cycle phases at different time points after treating with resveratrol were further detected, and it was found that the cells were arrested in the S phase because of the percentage of cells in S phase increased and cells in G1/G0 phase decreased. In conclusion, resveratrol can inhibit the proliferation of 4T1 cancer cells by inhibiting cell cycle and inducing apoptosis. Key Contribution:Resveratrol exerts a more obvious toxic effect on cancer cells to induce apoptosis in a time-and dose-dependent manner. RNA-seq was used to overall explore potential mechanisms from a transcriptional level.

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“…MEs have a high capacity for drug loading, and because they have a high capacity for solubilizing drugs [62], they can get through the stratum corneum barrier and partition the medication into the skin [63,64]. A study indicated that MEs protect the RSV from ultraviolet B (UVB) radiation for up to 1 h and delay photodegradation which further helps in uptakes of RSV in the skin [65].…”

Section: Microemulsionsmentioning

confidence: 99%

Potential role of resveratrol and its nano-formulation as anti-cancer agent

Kumar

Kurmi

Singh

et al. 2022

Exploration of Targeted Anti-Tumor Therapy

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The uncontrolled and metastatic nature of cancer makes it worse and more unpredictable. Hence, many therapy and medication are used to control and treat cancer. However, apart from this, many medications cause various side effects. In America, nearly 8% of patients admitted to the hospital are due to side effects. Cancer is more seen in people residing in developed countries related of their lifestyle. There are various phytoconstituents molecules in which resveratrol (RSV) is the best-fitted molecule for cancer due to its significantly less adverse effect on the body. RSV inhibits the initiation and progression of cell proliferation due to the modulation of various pathways like the phosphoinositol 3 kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway. RSV downgraded cell cycle-regulated proteins like cyclin E, cyclin D1, and proliferating cell nuclear antigen (PCNA) and induced the release of cytochrome c from the mitochondria, causing apoptosis or programmed cell death (PCD). A great benefit comes with some challenges, hence, RSV does suffer from poor solubility in water i.e. 0.05 mg/mL. It suffers from poor bioavailability due to being highly metabolized by the liver and intestine. Surprisingly, RSV metabolites also induce the metabolism of RSV. Hence, significantly less amount of RSV presented in the urine in the unchanged form. Due to some challenges like poor bioavailability, less aqueous solubility, and retention time in the body, researchers concluded to make the nanocarriers for better delivery. Adopting the technique of nano-formulations, increased topical penetration by up to 21%, improved nano-encapsulation and consequently improved bioavailability and permeability by many folds. Hence, the present review describes the complete profile of RSV and its nano-formulations for improving anti-cancer activity along with a patent survey.

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Testing of resveratrol microemulsion photostability and protective effect against UV induced oxidative stress

Cited by 20 publications

References 16 publications

Role of Resveratrol in Regulating Cutaneous Functions

Role of Resveratrol in Regulating Cutaneous Functions

The Cytotoxicity Effect of Resveratrol: Cell Cycle Arrest and Induced Apoptosis of Breast Cancer 4T1 Cells

Potential role of resveratrol and its nano-formulation as anti-cancer agent

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