The changing global climate, characterized by rising surface air temperatures, shifting precipitation patterns, and heightened occurrences of extreme weather events, is anticipated to profoundly impact the environment, economy, and society worldwide. This impact is particularly acute in African nations like Angola, where crucial sectors, such as agriculture, rely heavily on climate variability and exhibit limited adaptive capacity. Given that the majority of Angola’s agriculture is rain-fed and serves as a vital source of livelihood for the populace, the country is especially vulnerable to climate change, particularly in its southern region. Climate change has caused severe damage in Angola, especially in the southern part of the country, where the worst droughts in decades have affected over 3.81 million people, resulting in food and water shortages. Between 2005 and 2017, climate-related disasters cost the country about 1.2 billion US dollars, further exacerbating the economic and social challenges faced by the population. This study presents a systematic review of the effects of climate change on agriculture in Angola, with a focus on the southern region. Employing the PRISMA2020 methodology, the review examined 431 documents from databases such as Scopus and Web Science, spanning from 1996 to 2023, with 63 meeting inclusion criteria. The review reveals a paucity of research on the short and long-term impacts of climate change on Angolan agriculture. Projections indicate a rise in temperatures and a general decrease in precipitation, with the southern region experiencing a more pronounced decline. Agricultural productivity may suffer significantly, with models suggesting a potential 7% reduction by 2050.