Testing the Effects of Cinnamon Extract Supplementation on Inflammation and Oxidative Stress Induced by Acrylamide

Haidari, Fatemeh; Mohammadshahi, Majid; Abiri, Behnaz; Guest, Paul C.; Zarei, Mehdi; Fathi, Mojdeh

doi:10.1007/978-1-0716-1558-4_11

Cited by 10 publications

(9 citation statements)

References 30 publications

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“…Various cinnamon extracts, such as Cinnamomum zeylanicum Blume essential oil, ethanol extracts of cinnamon bark, cinnamon bark aqueous extract, and methanolic crude extract of Cinnamomum verum, display antioxidant activity, which indicates the potential for cinnamon to manage oxidative stress-related disorders [32]. Most cinnamon studies in vitro and in vivo (Table 2) [9,[33][34][35][36][37][38][39][40][41][42][43][44][45][46][47] demonstrate significant antioxidant activity through multiple mechanisms, including reduction of malondialdehyde level (lipid peroxidation marker), activation of transcription factor Nrf2, and synthesis of antioxidant enzymes such as HO-1, superoxide dismutase, CAT, and GPx [48,49]. Twenty-two chemical ingredients have been isolated from cinnamon in addition to cinnamaldehyde analogues; of these, lignan pinoresinol (PRO) and the flavonol (-)-(2R,3R)-5,7-dimethoxy-3', 4'-methylenedioxy-flavan-3-ol (MFO) display antioxidant capacity [50].…”

Section: Cinnamonmentioning

confidence: 99%

Cinnamon: an aromatic condiment applicable to chronic kidney disease

Moreira

Brum

Reis

et al. 2023

Kidney Res Clin Pract

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Cinnamon, a member of the Lauraceae family, has been widely used as a spice and traditional herbal medicine for centuries and hasshown beneficial effects in cardiovascular disease, obesity, and diabetes. However, its effectiveness as a therapeutic intervention forchronic kidney disease (CKD) remains unproven. The bioactive compounds within cinnamon, such as cinnamaldehyde, cinnamicacid, and cinnamate, can mitigate oxidative stress, inflammation, hyperglycemia, gut dysbiosis, and dyslipidemia, which are commoncomplications in patients with CKD. In this narrative review, we assess the mechanisms by which cinnamon may alleviate complicationsobserved in CKD and the possible role of this spice as an additional nutritional strategy for this patient group.

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Section: Cinnamonmentioning

confidence: 99%

Cinnamon: an aromatic condiment applicable to chronic kidney disease

Moreira

Brum

Reis

et al. 2023

Kidney Res Clin Pract

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“… 66 Administration of 35 mg/kg/day of acrylamide by gastric gavage for 2 weeks to adult male rats resulted in a significant increase in serum TNF-α and leptin levels in the rats, compared with the control group. 67 Increased leptin levels in the blood (hyperleptinemia), observed as a comorbidity of obesity, 68 is associated with adipose tissue inflammation. 69 , 70 Possible mechanisms for the effects of acrylamide associated with obesity and its comorbidities, along with the extent to which it worsens them, will be discussed in detail in the following section.…”

Section: Development Of the Obesogen Hypothesismentioning

confidence: 99%

“… 89 It has been reported that there is a steady endogenous acrylamide level of 0.3–0.4 microgram/kilogram (µg/kg) body weight/day (bw/d) in the blood of healthy nonsmokers. 114 Humans are widely exposed to acrylamide, 26 , 78 , 114–116 and studies in humans and laboratory animals exposed to various doses of acrylamide for various durations have shown that exposure to acrylamide has been associated with a number of effects that are harmful to health, such as neurotoxicity, 117 , 118 carcinogenicity, 119 , 120 genotoxicity, 121–123 hepatotoxicity, 67 , 124 and impaired placental development. 125 Acrylamide is taken into the body through the skin, inhalation, or digestion, and the majority (90%) of acrylamide is rapidly metabolized; a very small part of it is excreted in the urine.…”

Section: Acrylamide: Chemical Properties Formation In Foods Effects O...mentioning

confidence: 99%

From a toxin to an obesogen: a review of potential obesogenic roles of acrylamide with a mechanistic approach

Büyükdere

Akyol

2023

Nutrition Reviews

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Obesity and obesity-related disorders such as cancer, type 2 diabetes, and fatty liver have become a global health problem. It is well known that the primary cause of obesity is positive energy balance. In addition, obesity is the consequence of complex gene and environment interactions that result in excess calorie intake being stored as fat. However, it has been revealed that there are other factors contributing to the worsening of obesity. The presence of nontraditional risk factors, such as environmental endocrine-disrupting chemicals, has recently been associated with obesity and comorbidities caused by obesity. The aim of this review was to examine the evidence and potential mechanisms for acrylamide having endocrine-disrupting properties contributing to obesity and obesity-related comorbidities. Recent studies have suggested that exposure to environmental endocrine-disrupting obesogens may be a risk factor contributing to the current obesity epidemic, and that one of these obesogens is acrylamide, an environmental and industrial compound produced by food processing, particularly the processing of foods such as potato chips, and coffee. In addition to the known harmful effects of acrylamide in humans and experimental animals, such as neurotoxicity, genotoxicity, and carcinogenicity, acrylamide also has an obesogenic effect. It has been shown in the literature to a limited extent that acrylamide may disrupt energy metabolism, lipid metabolism, adipogenesis, adipocyte differentiation, and various signaling pathways, and may exacerbate the disturbances in metabolic and biochemical parameters observed as a result of obesity. Acrylamide exerts its main potential obesogenic effects through body weight increase, worsening of the levels of obesity-related blood biomarkers, and induction of adipocyte differentiation and adipogenesis. Additional mechanisms may be discovered. Further experimental studies and prospective cohorts are needed, both to supplement existing knowledge about acrylamide and its effects, and to clarify its established relationship with obesity and its comorbidities.

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“…DPPH activity regarding the extract of barks from C. zeylanicumhas been measured base on a previous approach conducted via Blois's method [13]and with a few modifications. [14] Assessment of the biochemical parameters Reactive oxygen species (ROS), were determinate using ELISA method by standard kits (Sunlong, China).The malondialdehyde (MDA) concentration was assayed for lipid peroxidation, MDA reacts with thiobarbituric acid to give MDA-TBA pink complex ,MDA assessment spectrophotometrically [15]. Total antioxidant (TAC) and Total oxidant stress (TOS) were determine by Erel method [16][17].…”

Section: Dpph (Radical Scavenging Activity) Of Cinnamon Extractsmentioning

confidence: 99%

Cinnamon Zeylanicum Aqueous Improves Some Oxidative Stress Biomarkers in Diabetic Type 2 Induced By Streptozotocin in Adult Male Albino Mice

yaseen

Mohammed

2022

Egypt. J. Chem.

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Background: the diabetic type 2 population development in the world wide. Its risk describe through the long term complication that provide in destroyed the variety tissues in organs as liver and blood vessels. Cinnamon zeylanicum classes as famous medicinal herb , contain large numbers of antioxidant phytochemical compounds: (cinnamaldehyde ,eugenol ,Gallic acid, rutin) and others phenolic compounds and vitamins as(A,K,E,D3,K,C,B1,B2) ,also researches indicated that cinnamon contain interesting minerals like ( zinc, copper, Iron, cobalt).therefor cinnamon have capacity to treated T2DM . Aim: present study aimed to investigation in vitro and in vivo antioxidant effect of aqueous bark extract of C. zeylanicumon oxidative stress in T2DM induce by Streptozotocin (STZ) in mice .Methodology: DPPH free radical scavenging use to evaluated antioxidant activity in vitro. In vivo: Eighty adult male, albino mice were be used and divided into four (n=20).group (A) normal healthy control mice. Group (B) received (200mg/kg) cinnamon aqueous bark extract only. Group (C)mice fed with high fat diet for three weeks and received with (40 mg /kg) STZ injection (diabetic mice group).group (D) firstly treated by the same condition of group (C) and after (10 days) of STZ injunction the diabetic mice treated with (200 mg /kg) of cinnamon extract . Hyperglycemia was investigation by FBS and oxidative stress was investigation by permeant ROS, MDA, TOS and the total antioxidant capacity TAC in serum. Rustle: cinnamon zeylanicum extract showed effective DPPH free radical. Control group(A) compared T2DM group (C) and treatment group (D), herb caused a significant (p≤0.001) reduction in ROS,MDA,TOS, and a significant increase in total antioxidant capacity TAC also showed significant improvement in FBS and serum insulin. Conclusion: cinnamon zeylanicum a protective effect against oxidative stress in diabetic mice due to its antioxidant characters.

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Testing the Effects of Cinnamon Extract Supplementation on Inflammation and Oxidative Stress Induced by Acrylamide

Cited by 10 publications

References 30 publications

Cinnamon: an aromatic condiment applicable to chronic kidney disease

Cinnamon: an aromatic condiment applicable to chronic kidney disease

From a toxin to an obesogen: a review of potential obesogenic roles of acrylamide with a mechanistic approach

Cinnamon Zeylanicum Aqueous Improves Some Oxidative Stress Biomarkers in Diabetic Type 2 Induced By Streptozotocin in Adult Male Albino Mice

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