The August 1953 seismic sequence comprised the most destructive events in the recent history of Greece. The mainshock on 12 August, and its foreshocks on 9 and 11 August, devastated the southern Ionian Islands. The existing literature emphasized the destructive effects of the earthquakes on buildings, as well as to the emergency response and recovery actions. This resulted in a large gap in capturing the full picture of the earthquake’s environmental effects. The present study aims to fill this gap by reconstructing the most complete picture possible of the primary and secondary effects on the environment of the southern Ionian Islands by the August 1953 earthquakes. This reconstruction is based on all available sources, comprising not only the existing scientific literature, but especially sources that have not been considered to date, including newspapers of local and national circulation. In total, 120 cases of the earthquake’s environmental effects were identified, comprised of 33 cases of primary and 87 cases of secondary effects. In descending order of occurrence, slope failures, co-seismic uplift, hydrological anomalies, ground cracks, tsunami, liquefaction, dust clouds, hydrocarbon-related phenomena, jumping stones and vegetation effects were distributed mainly in Cephalonia Island and secondarily in the Ithaki and Zakythos Islands. The primary effects were mainly detected in eastern Cephalonia, which presented uplift of up to 70 cm, while the majority of the secondary effects were triggered in specific zones with characteristics that made them susceptible to the occurrence of earthquake-related hazards.