Testosterona Sérica en Trastornos Hipertensivos Del Embarazo

Á, Cristina Irribarra; Almuna, R; M, Sócrates Aedo; J, Arnaldo Porcile

doi:10.4067/s0717-75262007000100006

Cited by 1 publication

(1 citation statement)

References 28 publications

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“…A year later, in 2007, in Chile, Irribarra et al, looking to clarify whether there is also an association between hyperandrogenemia and chronic/pre-existing hypertension (CH) in pregnant women, designed a study that included normotensive, pre-eclamptic, and chronic hypertensive pregnant women and measured BP, fT, and total T levels [ 81 ]. Regarding BP, women with PE and CH exhibited significantly different BP when compared to normotensive women; the highest BP was detected in PE.…”

Section: Effects Of Testosterone In Pre-eclampsiamentioning

confidence: 99%

Relationship between Androgens and Vascular and Placental Function during Pre-eclampsia

Fernandes,

Lorigo,

Cairrao

2024

CIMB

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Hypertensive disorders of pregnancy (HDP) represent a substantial risk to maternal and fetal health. Emerging evidence suggests an association between testosterone and pre-eclampsia (PE), potentially mediated through androgen receptors (AR). Nevertheless, the mechanism driving this association is yet to be elucidated. On the other hand, reports of transgender men’s pregnancies offer a limited and insightful opportunity to understand the role of high androgen levels in the development of HDP. In this sense, a literature review was performed from a little over 2 decades (1998–2022) to address the association of testosterone levels with the development of HDP. Furthermore, this review addresses the case of transgender men for the first time. The main in vitro outcomes reveal placenta samples with greater AR mRNA expression. Moreover, ex vivo studies show that testosterone-induced vasorelaxation impairment promotes hypertension. Epidemiological data point to greater testosterone levels in blood samples during PE. Studies with transgender men allow us to infer that exogenous testosterone administration can be considered a risk factor for PE and that the administration of testosterone does not affect fetal development. Overall, all studies analyzed suggested that high testosterone levels are associated with PE.

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Section: Effects Of Testosterone In Pre-eclampsiamentioning

confidence: 99%