Testosterone and estradiol treatments differently affect pituitary-thyroid axis and liver deiodinase 1 activity in orchidectomized middle-aged rats

Šošić‐Jurjević, Branka; Filipović, Branko; Renko, Kostja; Miler, Marko; Trifunović, Svetlana; Ajdžanović, Vladimir; Köhrle, Josef; Milošević, Verica

doi:10.1016/j.exger.2015.09.010

Cited by 24 publications

(32 citation statements)

References 47 publications

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“…It is likely that testosterone potentiates anti‐inflammatory and immune‐suppressive effects of selenomethionine by stimulating activity of selenium‐containing iodothyronine deiodinases or by increasing tissue selenium content. In line with this explanation orchidectomy reduced activities of type 1 deiodinase in the liver and of type 2 deiodinase in the pituitary, and the opposite effect on type 1 deiodinase in the liver was exerted by testosterone . Moreover, healthy chickens treated with testosterone had slightly higher serum selenium levels than untreated animals .…”

Section: Discussionsupporting

confidence: 52%

“…In line with this explanation orchidectomy reduced activities of type 1 deiodinase in the liver and of type 2 deiodinase in the pituitary, 32 and the opposite effect on type 1 deiodinase in the liver was exerted by testosterone. 33 Moreover, healthy chickens treated with testosterone had slightly higher serum se-lenium levels than untreated animals. 34 Finally, taking into account that testosterone preparations reduced the production of interleukin-1β, interleukin-6, and tumor necrosis factor-α, 35 playing a role in the pathogenesis of autoimmune thyroiditis, 4 testosterone may enhance selenomethionine action by exerting direct antiinflammatory and immune-suppressive effects.…”

Section: Discussionmentioning

confidence: 98%

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The Effect of Selenomethionine on Thyroid Autoimmunity in Euthyroid Men With Hashimoto Thyroiditis and Testosterone Deficiency

Krysiak

Kowalcze

2019

The Journal of Clinical Pharma

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Hashimoto (autoimmune) thyroiditis develops much less frequently in men than in women, suggesting that androgens have a protective effect against thyroid autoimmunity. The current study was aimed at investigating whether the effect of selenomethionine on thyroid antibody titers and thyroid function tests in euthyroid men with autoimmune thyroid disease depends on testosterone levels. The study population consisted of 2 age‐matched, weight‐matched, and thyroid antibody titer–matched groups of euthyroid men with Hashimoto thyroiditis and testosterone deficiency: 18 patients receiving intramuscular testosterone enanthate (100 mg once weekly) and 19 testosterone‐naive men. All subjects were than treated with selenomethionine (200 µg daily) for 6 months. Serum titers of thyroid antibodies, thyrotropin, free thyroid hormones, and testosterone as well as calculated parameters of thyroid homeostasis were assessed at the beginning and at the end of the study. At baseline, except for testosterone, there were no differences between the 2 treatment arms in thyroid antibody titers, serum hormone levels, or values of all calculated indices. Although selenomethionine reduced thyroid peroxidase and thyroglobulin antibody titers in both treatment arms, these effects were stronger in testosterone‐treated than in testosterone‐untreated men. Only in men receiving testosterone, selenomethionine altered the free thyroxine/free triiodothyronine ratio, testosterone levels, and structure parameter interference approach‐GT and structure parameter interference approach‐GD. Selenomethionine‐induced changes in thyroid antibody titers correlated with the effect of treatment on structure parameter interference approach‐GT and testosterone. The obtained results suggest that testosterone determines the strength of selenomethionine action in euthyroid men with autoimmune thyroiditis.

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 98%

The Effect of Selenomethionine on Thyroid Autoimmunity in Euthyroid Men With Hashimoto Thyroiditis and Testosterone Deficiency

Krysiak

Kowalcze

2019

The Journal of Clinical Pharma

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“…Nevertheless SNPs in DIO1 found in several independent GWAS studies indicate that Dio1 plays a primary role in determining the set point of circulating T3 in euthyroid patients. Also, testosterone may play a role in Dio1 activity as observed in orchidectomized rats as the replacement with testosterone after surgery was shown to maintain normal Dio1 activity in liver (Sosic-Jurjevic et al, 2015). …”

Section: The Deiodinasesmentioning

confidence: 99%

New insights into thyroid hormone action

Mendoza

Hollenberg

2017

Pharmacology & Therapeutics

207

136

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Thyroid hormones (TH) are endocrine messengers essential for normal development and function of virtually every vertebrate. The hypothalamic-pituitary-thyroid axis is exquisitely modulated to maintain nearly constant TH (T4 and T3) concentrations in circulation. However peripheral tissues and the CNS control the intracellular availability of TH, suggesting that circulating concentrations of TH are not fully representative of what each cell type sees. Indeed, recent work in the field has identified that TH transporters, deiodinases and thyroid hormone receptor coregulators can strongly control tissue-specific sensitivity to a set amount of TH. Furthermore, the mechanism by which the thyroid hormone receptors regulate target gene expression can vary by gene, tissue and cellular context. This review will highlight novel insights into the machinery that controls the cellular response to TH, which include unique signaling cascades. These findings shed new light into the pathophysiology of human diseases caused by abnormal TH signaling.

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“…However, no difference in D1 mRNA levels and activity was observed after β‐estradiol (E2) administration or ovariectomy in female rats. A more recent study by Šošić‐Jurjević et al also showed that orchidectomy of young rats resulted in a decrease in D1 activity and thyroid‐stimulating hormone levels, and that testosterone administration resulted in a recovery of D1 activity and thyroid‐stimulating hormone levels to control levels. However, there is to our knowledge no information available on the underlying mechanisms that link testosterone levels, D1 activity, and the regulation of the HPT axis in rats or any other vertebrates.…”

Section: Discussionmentioning

confidence: 94%

Relationships between polybrominated diphenyl ethers and transcription and activity of type 1 deiodinase in a gull highly exposed to flame retardants

François

Técher

Houde

et al. 2016

Enviro Toxic and Chemistry

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Deca-brominated diphenyl ether (deca-BDE), composed mainly of BDE-209, is subject to usage restrictions in North America and Europe, although global action on its continued use has yet to be undertaken. Relatively large concentrations of polybrominated diphenyl ethers (PBDEs), especially BDE-209 and its higher brominated degradation products, have been reported in tissues of ring-billed gulls (Larus delawarensis) breeding near the densely populated city of Montreal (QC, Canada). There is limited knowledge of BDE-209 biotransformation and toxicokinetics in birds. Deiodinases, a class of enzymes catalyzing thyroid hormone conversion, have been suggested to be involved in BDE-209 debromination in birds. The objective of the present study was to investigate the relationships between PBDE concentrations and type 1 deiodinase (D1) transcription and in vitro activity (microsomes) in livers of Montreal-breeding ring-billed gulls. The ring-billed gulls exhibiting the highest D1 activity in liver microsomes accumulated the greatest liver concentrations of hepta-BDEs and octa-BDEs. Activity of D1 was inversely related to concentration ratios of BDE-209 to octa-BDEs and ∑hepta-BDE. An even stronger inverse relation was found between D1 activity and BDE-209 to ∑nona + octa + hepta-BDE concentration ratios. The messenger ribonucleic acid (mRNA) levels of D1 in gull livers were inversely associated with liver concentrations of ∑octa-BDE. The present study's findings suggest that D1 is potentially involved in BDE-209 biotransformation and accumulation of higher brominated PBDEs in livers of ring-billed gulls. Environ Toxicol Chem 2016;35:2215-2222. © 2016 SETAC.

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Testosterone and estradiol treatments differently affect pituitary-thyroid axis and liver deiodinase 1 activity in orchidectomized middle-aged rats

Cited by 24 publications

References 47 publications

The Effect of Selenomethionine on Thyroid Autoimmunity in Euthyroid Men With Hashimoto Thyroiditis and Testosterone Deficiency

The Effect of Selenomethionine on Thyroid Autoimmunity in Euthyroid Men With Hashimoto Thyroiditis and Testosterone Deficiency

New insights into thyroid hormone action

Relationships between polybrominated diphenyl ethers and transcription and activity of type 1 deiodinase in a gull highly exposed to flame retardants

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