2020
DOI: 10.1073/pnas.2004363117
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Testosterone and hippocampal trajectories mediate relationship of poverty to emotion dysregulation and depression

Abstract: There is robust evidence that early poverty is associated with poor developmental outcomes, including impaired emotion regulation and depression. However, the specific mechanisms that mediate this risk are less clear. Here we test the hypothesis that one pathway involves hormone mechanisms (testosterone and DHEA) that contribute to disruption of hippocampal brain development, which in turn contributes to perturbed emotion regulation and subsequent risk for depression. To do so, we used data from 167 children p… Show more

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Cited by 32 publications
(27 citation statements)
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“…Living in poverty is also associated with shallower increases of testosterone, in both boys and girls, at all stages of growth (Barch et al 2020). Reduced testosterone may slow both skeletal growth and development of the hippocampus, the latter being important to emotion regulation.…”
Section: Two Examples Of the Role Of Sepe Factors Regulating Human Growthmentioning
confidence: 99%
“…Living in poverty is also associated with shallower increases of testosterone, in both boys and girls, at all stages of growth (Barch et al 2020). Reduced testosterone may slow both skeletal growth and development of the hippocampus, the latter being important to emotion regulation.…”
Section: Two Examples Of the Role Of Sepe Factors Regulating Human Growthmentioning
confidence: 99%
“…Testosterone is the main sex steroid hormone responsible for the development of primary and secondary sexual characteristics in males (Eisenegger et al 2011). Previous literature has shown not only relationships between testosterone levels and the expression of personality traits in both sexes (Giammanco et al 2005;Cobey et al 2015;Costa et al 2015;Borráz-León et al 2018, see also Luoto et al 2019;Luoto 2020), but also associations between abnormally high or low testosterone concentration and the development of some mental disorders such as depression, anxiety, and bipolar disorder (Booth et al 1999;Khera 2013; Barch et al 2020).…”
Section: Introductionmentioning
confidence: 99%
“…Additionally, it was found that ACE significantly enhanced the contents of testosterone in the brain. Resent study demonstrated that testosterone could prevent depression through MAPK/ERK2 signaling pathway ( 63 ). Linoleamide is an important active ingredient of Maca, which could regulate the energy metabolism and increased the antioxidant capacity ( 64 ).…”
Section: Discussionmentioning
confidence: 99%