Testosterone and its binding in hyperthyroid women before and under antithyroid drug therapy

Abstract

Abstract. The serum concentrations of the different forms of circulating testosterone, total testosterone, free testosterone and non-sex-hormone binding globulin bound testosterone (albumin bound + free fractions) which is considered as the biovailable hormone, were measured in 15 hyperthyroid women before and after anti-thyroid drug therapy and in 15 age-matched healthy women. Sex-hormone binding globulin and albumin were quantified. Total testosterone was significantly higher in hyperthyroid women before treatment, whereas free testosterone and non sex-hormone binding globulin bound testosterone were significantly decreased. After recovery, all the parameters returned to the normal range. In hyperthyroid patients, the variations in the different fractions of testosterone can be related to the rise of sex-hormone binding globulin. These variations could be explained by the displacement of the equilibrium defined by the binding equation.

Ovarian Ultrasound and Ovarian and Adrenal Hormones before and after Treatment for Hyperthyroidism

“…Hyperandrogenism and/or a disturbed gonadotropin pattern are the endocrine abnormalities most commonly associated with PCOS. However, hyperthyroid women can be considered hypoandrogenic rather than hyperandrogenic as indicated by their wellknown appearance with soft skin and fine downy hair growth and by their low pretreatment levels of fT and other indices of biologically active testosterone found in the present study and in previous investigations [16][17][18][19][20].…”

Effect of aqueous rosemary extract on some sexual hormones in male rats with high thyroxine level

“…This oddity of the hypothalamic-pituitary-gonadal axis correlates with the concentrations of serum T4 and regain the normal correction of the hyperthyroidism by treatment with thyroid hormone inhibitors as the use of PTU in our study. The concentration of sex hormone-binding globulin (SHBG) in serum or plasma is increased (26) that is associated with the rise in total testosterone level (27). The changes in the concentration of total testosterone resulted in a studied blood outcome rate for testosterone in patients with hyperthyroidism that is not significantly diverse from normal individuals (28).…”