Testosterone, androstenedione and dehydroepiandrosterone concentrations in pregnant Spanish Purebred mare

Satué, K.; Marcilla, María Asunción Menargues; Medica, Pietro; Ferlazzo, Adriana; Fazio, Esterina

doi:10.1016/j.theriogenology.2018.09.025

Cited by 9 publications

(9 citation statements)

References 28 publications

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“…This increase in estrogens temporarily coincides with the hypertrophy of fetal gonads, which together with local expression of the enzyme 17α-hydroxylase, lead to elevated umbilical levels of P5, T and DHEA [134]. At the same time, maternal plasma concentrations of T and DHEA increase after 100 days of gestation, reaching maximum values at 6 months [116,135] to promote greater perfusion in the fetal compartment and the uterine tonicity [27,136]. Legacki et al [112] describe DHEA values that increase since the first 2 months of gestation to at 6-8 months, decreasing afterward.…”

Section: Progestagensmentioning

confidence: 97%

“…Additionally, the presence of eCG causes a change in luteal steroidogenesis. In this case, CL changes from synthesizing only P 4 to secreting also estrogens and androgens, increasing plasma levels rapidly and tripling the basal values [116]. However, it is not until approximately day 35 that systemic estrogen rises.…”

Section: Hormonal Regulation Of Pregnancy In Normal Mares 41 Progestmentioning

confidence: 97%

“…Although the mechanism by which gonadotropin exerts this activity is unknown, an increase in the expression of the enzyme 17α-hydroxylase in charge of the conversion of P 5 into dehydroepiandrosterone (DHEA) and P 4 into A 4 has been described. Both events coincide with the secretion of eCG, they seem to be limited to the first period since they are not detected towards the middle of gestation [116]. The increase in P 4 responds primarily to the growth of primary CL and the development of secondary and accessory CLs [4,117].…”

Section: Hormonal Regulation Of Pregnancy In Normal Mares 41 Progestmentioning

confidence: 99%

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Physiological and Clinical Aspects of the Endocrinology of the Estrous Cycle and Pregnancy in Mares

Satué¹,

Gardón²

2021

Animal Reproduction in Veterinary Medicine

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The use of advanced reproductive endocrinology can generate important economic benefits for equine breeding farms. Pregnancy in the mare involves considerable endocrine changes, which can be explained in part by the development of different structures such as embryonic vesicles, primary and secondary CL, endometrial cups and development of fetoplacental units. Both the pregnant mare and the fetus adapt to this development with unique mechanisms, such as alterations in the maternal endocrine metabolism and hormonal feedback. Since the ability to produce a viable foal is critical for the broodmare, the maintenance of the gestation implies almost a year of physiological effort. Therefore, the joint knowledge of basic reproductive science and current clinical endocrinology allows veterinarians and breeders to be better positioned to achieve their objectives. This chapter reviews normal and abnormal endocrine patterns during the equine estrual cycle, pregnancy. We also consider hormonal evaluation related to placentitis, abortions, recurrent pregnancy loss, and premature deliveries. Also, several aspects associated with endocrinological control of the reproductive cycle, ovulation, parturition, high-risk mare, and hormone supplementation will be developed.

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Section: Progestagensmentioning

confidence: 97%

Section: Hormonal Regulation Of Pregnancy In Normal Mares 41 Progestmentioning

confidence: 97%

Section: Hormonal Regulation Of Pregnancy In Normal Mares 41 Progestmentioning

confidence: 99%

See 1 more Smart Citation

Physiological and Clinical Aspects of the Endocrinology of the Estrous Cycle and Pregnancy in Mares

Satué¹,

Gardón²

2021

Animal Reproduction in Veterinary Medicine

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“…The horse fetus produces a considerable amount of DHEA that is probably used by the allantochorion to synthesize estrogens (53). However, a considerable amount of DHEA escapes the placenta, as its concentrations in the maternal circulation are quite high, displaying values around 3-6 nM in early pregnancy, peaking to 50-60 nM in mid-pregnancy, and then decreasing toward the end of pregnancy (54,55). DHEAS was detected in all mares between 7 and 9 weeks of gestation, when its concentrations were around 27 nM.…”

Section: Placentamentioning

confidence: 99%

Do Dehydroepiandrosterone (DHEA) and Its Sulfate (DHEAS) Play a Role in the Stress Response in Domestic Animals?

et al. 2020

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In animal husbandry, stress is often associated with poor health and welfare. Stress occurs when a physiological control system detects a state of real or presumptive threat to the animal's homeostasis or a failure to control a fitness-critical variable. The definition of stress has mostly relied on glucocorticoids measurement, even though glucocorticoids represent one stress-response system, the hypothalamus-pituitary-adrenocortical axis, which is not precise enough as it is also related to metabolic regulation and activated in non-stressful situations (pleasure, excitement, and arousal). The mammal adrenal can synthesize the androgenic steroid dehydroepiandrosterone (DHEA) and its sulfate metabolite (DHEAS), which have been associated to the stress response in several studies performed mostly in humans and laboratory animals. Although the functions of these steroids are not fully understood, available data suggest their antagonistic effects on glucocorticoids and, in humans, their secretion is affected by stress. This review explores the scientific literature on DHEA and DHEAS release in domestic animals in response to stressors of different nature (inflammatory, physical, or social) and duration, and the extra-adrenal contribution to circulating DHEA. Then, the potential use of DHEA in conjunction with cortisol to improve the definition of the stress phenotype in farmed animals is discussed. Although the focus of this review is on farmed animals, examples from other species are reported when available.

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“…The concentrations of T (ng/mL), A 4 (ng/mL) and DHEA (ng/mL) in plasma and FF were determined by enzyme immunoassay (EIA) techniques, using polyclonal antibodies (anti-T: R156, anti-A 4 : C9111 and anti-DHEA: C1011, Clinical Endocrinology Laboratory, UC Davis, California, USA), and hormone-peroxidase conjugates (conjugate of T: T3CMO-HRP, conjugate of A 4 : A3CMO-HRP and conjugate of DHEA: DHEA17CMO-HRP, Clinical Endocrinology Laboratory, UC Davis, California, USA), validated specifically in the equine species based on the technique proposed by Munro and Lasley [24] and previously used by these same researchers [25]. The detection limits for T, A 4 and DHEA concentrations were 30 ng/mL, 25 ng/mL and 40 ng/mL, respectively.…”

Section: Collection Of Follicular Fluidmentioning

confidence: 99%

Can the Presence of Ovarian Corpus Luteum Modify the Hormonal Composition of Follicular Fluid in Mares?

Satué

Fazio

Medica

2020

Animals

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The hypothesis of this study was to investigate if the presence of corpus luteum (CL) in one ovary could modify the hormonal content of follicular fluid (FF) in the follicles. Sixty ovaries were taken after the slaughter of 30 clinically healthy mares. In relation to the sizes, the follicles were classified into three different categories, as small (20–30 mm), medium (31–40 mm) and large (≥41 mm). Blood samples were collected from the jugular vein of mares before their slaughter, and then the FF samplings were extracted from each single follicle. The ovaries that were collected were classified into two groups, according to the presence (CL-bearing) or absence (non-CL-bearing) of CL. The serum and FF samples were analysed for progesterone (P4), oestradiol-17β (E2), testosterone (T), androstenedione (A4) and dehydroepiandrosterone (DHEA). Intrafollicular P4 concentrations in large follicles of CL-bearing groups were lower than for non-CL-bearing ones. Intrafollicular E2 concentrations increased with the increase of the follicle diameter in both groups, CL-bearing and non-CL-bearing. However, in the FF with a large and medium follicle size, E2 concentrations were significantly higher in non-CL-bearing groups than in CL-bearing groups. T and A4 significantly increased in the large and medium follicle sizes when compared to the small follicle sizes in both groups, but higher concentrations in the non-CL-bearing group were obtained. Intrafollicular DHEA significantly decreased with the increase of the follicular diameter in both groups. Steroid hormones in FF dynamically changed, according to the presence or not of CL in the ovary. This study brings new knowledge on the role of the CL in the follicular hormonal composition in mares.

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Testosterone, androstenedione and dehydroepiandrosterone concentrations in pregnant Spanish Purebred mare

Cited by 9 publications

References 28 publications

Physiological and Clinical Aspects of the Endocrinology of the Estrous Cycle and Pregnancy in Mares

Physiological and Clinical Aspects of the Endocrinology of the Estrous Cycle and Pregnancy in Mares

Do Dehydroepiandrosterone (DHEA) and Its Sulfate (DHEAS) Play a Role in the Stress Response in Domestic Animals?

Can the Presence of Ovarian Corpus Luteum Modify the Hormonal Composition of Follicular Fluid in Mares?

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