Testosterone binding in the cytosol of bovine corneal epithelium

Ploc, I; Stárka, L.

doi:10.1016/0014-4835(79)90110-6

Cited by 8 publications

(2 citation statements)

References 16 publications

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“…Sex steroid receptor mRNAs exist in a variety of ocular tissues, including the cornea, and these sites may represent target organs for androgens, estrogens and progestins . Similarly, androgen binding sites have been described in the bovine corneal epithelium , and it has been suggested that they play a role in wound healing and in stimulating corneal epithelial cell mitosis . Consequently, it is quite possible that sex steroid hormone levels in ocular tissues may increase or decrease in response to changes in the sex hormone environment .…”

Section: Discussionmentioning

confidence: 99%

The Influence of Donor and Recipient Gender Incompatibility on Corneal Transplant Rejection and Failure

Hopkinson

Romano

Kaye

et al. 2017

American Journal of Transplantation

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In vascularized organ transplants, gender mismatches have higher rates of immunological rejection. We investigated the influence of gender incompatibility, including H‐Y incompatibility, on corneal transplant graft rejection and failure. Patients were included who had undergone a first corneal transplant for keratoconus (KC), Fuchs endothelial dystrophy (FED), pseudophakic bullous keratopathy (PBK), infection and other indications. A Cox regression model was fitted for each indication to determine factors affecting graft failure and rejection at 5 years. The impact of gender, including H‐Y, matching was analyzed after accounting for other factors, including known risk factors. Of 18 171 patients, 4314 had undergone a transplant for FED, 4783 for KC, 3669 for PBK, 1903 for infection and 3502 for other disorders. H‐Y mismatched (male [M]→female [F]) corneas were at greater risk of graft failure or rejection. For FED, F→F were 40% less likely to fail (p < 0.0001) and 30% less likely to reject (p = 0.01); M→M were 20% less likely to fail (p = 0.04) and 30% less likely to reject (p = 0.01). For KC, M→M matched corneas were 30% less likely to fail (p = 0.05) and 20% less likely to reject (p = 0.01) compared with H‐Y mismatches. H‐Y antigen mismatched (M→F) patients were at greater risk of rejection or graft failure.

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Section: Discussionmentioning

confidence: 99%

The Influence of Donor and Recipient Gender Incompatibility on Corneal Transplant Rejection and Failure

Hopkinson

Romano

Kaye

et al. 2017

American Journal of Transplantation

View full text Add to dashboard Cite

show abstract

“…Since sex steroid receptors are present in lacrimal gland, acinar epithelial cells of the lacrimal gland, meibomian gland, lid, palpebral and bulbar conjunctiva, cornea, iris/ciliary body, lens, retina/ uvea, retina/choroids and retinal pigment epithelial cells of rats, rabbits and humans, the eye may be susceptible to hormone action following either local synthesis and/or topical or systemic application [1,[6][7][8][9][10][11]. Epidemiological studies have shown that some eye complaints are most common in women, a finding that would be consistent with either a detrimental effect of estrogen or a beneficial role of androgens, or both [2].…”

Section: Discussionmentioning

confidence: 99%