Testosterone deficiency and replacement: Myths and realities

Grober, Ethan

doi:10.5489/cuaj.2309

Cited by 11 publications

(9 citation statements)

References 33 publications

(34 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 2017 ). However, direct injection of artificial testosterone or oral testosterone administration can simultaneously induce many side effects, including prostate cancer, benign prostatic hyperplasia, and cardiovascular events (Grober 2014 ). Moreover, aging is a long process, and the long-term application of pharmacological levels of testosterone is limited by its potential side effects on health.…”

Section: Introductionmentioning

confidence: 99%

Steroidogenic effects ofTaraxacum officinaleextract on the levels of steroidogenic enzymes in mouse Leydig cells

Chung

Noh

Kim

et al. 2018

Animal Cells and Systems

View full text Add to dashboard Cite

In this study, we investigated the steroidogenic effect of Taraxacum officinale extract on mouse TM3 Leydig cells, which produce male hormones by increasing the levels of steroidogenic enzymes. Steroidogenic enzymes are involved in the production of testosterone in the testis. To date, the steroidogenic effect of T. officinale has not been reported. Therefore, we examined the steroidogenic effects of T. officinale extract (TOE) on mouse Leydig cells in vitro. Traditionally, plants have been used for the treatment of various kinds of ailments. For many years, some medicinal plants have been used to regulate steroidogenesis or late-onset hypogonadism (LOH). In particular, plants belonging to the genus Taraxacum have anti-inflammatory, anti-nociceptive, anti-oxidant, and anti-cancer properties. In this study, we determined whether the TOE exerts steroidogenic effects by increasing the levels of enzymes associated with steroidogenesis, such as the steroidogenic acute regulatory protein (STAR), CYP11A1, and translocator protein (TSPO) in the mitochondria and CYP17A1 in the smooth endoplasmic reticulum, in mouse Leydig cells. Our results showed that the TOE significantly increased the mRNA and protein levels of steroidogenic enzymes, thereby increasing the testosterone levels in mouse Leydig cells. Thus, our results indicate that the TOE increases the levels of steroidogenic enzymes, and further studies are required to establish the potential of this plant in regulating steroidogenesis and improving LOH.

show abstract

Section: Introductionmentioning

confidence: 99%

Steroidogenic effects ofTaraxacum officinaleextract on the levels of steroidogenic enzymes in mouse Leydig cells

Chung

Noh

Kim

et al. 2018

Animal Cells and Systems

View full text Add to dashboard Cite

show abstract

“…Signs of T deficiency include decreased muscle mass (sarcopenia) and loss of axillary and pubic hair. Anemia, higher than normal percentages of body fat, impaired cognition, mood lability and osteopenia/osteoporosis are other important signs found in hypogonadal individuals [9]. Quantification of T concentration can be achieved by using three main methods: sampling blood, urine or saliva.…”

Section: Diagnosis Of Male Hypogonadismmentioning

confidence: 99%

Cardiovascular Benefits of Testosterone Replacement Therapy in the Andropausal Male

Vatti¹,

Madanieh²,

Madanieh³

et al. 2015

Health

View full text Add to dashboard Cite

Androgen deficiency has been receiving a lot of attention as an evolving health concern in the industrialized world. With population aging, hypogonadism has become a challenging medical problem confronting practicing physicians. The importance of this increasingly prevalent disease arises from its potentially debilitating and serious consequences, such as atherosclerosis, diabetes mellitus, metabolic disorders, muscular weakness, psychiatric illness, sexual dysfunction and vascular inflammation. When left untreated, testosterone deficiency is associated with increased cardiovascular mortality.

show abstract

“…Concerns relating to prostate and cardiovascular health, performance enhancement via steroid abuse and the perception that TD is simply part of the "normal" process of aging has resulted in reluctance of many healthcare providers to diagnose and treat the condition. 3…”

Section: Introductionmentioning

confidence: 99%

Canadian Urological Association clinical practice guideline on testosterone deficiency in men: Evidence-based Q&A

Grober

Krakowsky

Khera

et al. 2021

CUAJ

Self Cite

View full text Add to dashboard Cite

In 2013, a comprehensive Canada-wide needs assessment revealed that over 25% of Canadian physicians were uncomfortable with the diagnosis and treatment of TD and identified significant knowledge gaps related to patient management. 4 To address the knowledge gaps, the Canadian Clinical Practice Guideline on the Diagnosis and Management of Testosterone Deficiency Syndrome in Adult Males was published in the CMAJ. 5 As part of its mandate, the guideline was offered as a "living document," to be updated periodically in a perpetual effort to incorporate advances in scientific and clinical discovery. The current CUA guideline was approached in this spirit and serves as an educational tool that builds on existing knowledge and offers a contemporary update to the literature. MethodsThe current guideline is structured as a series of Questions & Answers (Q&A) relating to the diagnosis and management of TD. By way of this structure, the guideline offers a practical, evidence-based overview and recommendations related to the diagnosis, treatment, monitoring, risks and benefits of TD and testosterone therapy. It was designed to be a straightforward and user-friendly guide for specialists (urologists, endocrinologists, psychiatrists, geriatricians), general practitioners and the patients they treat. The guideline offers Canadian-specific content with respect to knowledge and attitudes related to TD, laboratory diagnostic testing, Health Canada approved treatment formulations and funding considerations.The authorship group represents a panel of Canadian and international experts in the fields of men's health and TD. Representation is inter-provincial and multi-disciplinary covering the fields of urology, internal medicine/endocrinology and clinical biochemistry.Relevant publications on TD and testosterone therapy were sought using a combination of Medline, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL) and PubMed searches. The search strategy involved a series of key words including: testosterone deficiency, hypogonadism, low testosterone, androgen deficiency, andropause and testosterone replacement therapy. Filters included English language, human studies and an index date up to December 1, 2020. Recently published guidelines from the Canadian Men's Health Foundation, American Urological Association, The Endocrine Society and the European Association of Urology were included as supportive, summative content. [5][6][7][8][9] Whenever possible, guideline statements and recommendations have been assigned levels of evidence (LE) based on the GRADE Working Group framework (LE: high, moderate, low, very low quality of evidence). 10 In brief, randomized controlled trials were initially rated as highquality and observational studies as low-quality evidence. Additionally, the strength or importance of the recommendations was also graded as either "strong" or "weak" based on the quantity, quality, and consistency of the evidence available.Following a systematic search, panel members were asked to review the identif...

show abstract

Testosterone deficiency and replacement: Myths and realities

Cited by 11 publications

References 33 publications

Steroidogenic effects ofTaraxacum officinaleextract on the levels of steroidogenic enzymes in mouse Leydig cells

Steroidogenic effects ofTaraxacum officinaleextract on the levels of steroidogenic enzymes in mouse Leydig cells

Cardiovascular Benefits of Testosterone Replacement Therapy in the Andropausal Male

Canadian Urological Association clinical practice guideline on testosterone deficiency in men: Evidence-based Q&A

Contact Info

Product

Resources

About