Testosterone deficiency in male organ transplant recipients

Omil-Lima, Danly; Jesse, Erin; Gupta, Karishma; Sellke, Nicholas; Muncey, Wade; Burrelli, Corey C; Ghayda, Ramy Abou; Loeb, Aram; Thirumavalavan, Nannan

doi:10.1038/s41443-021-00513-9

Cited by 3 publications

(2 citation statements)

References 72 publications

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“…The progesterone receptor (PgR) is strongly associated with disease prognosis and therapeutic efficacy in hormone-related diseases such as endometriosis, breast, ovarian, and uterine cancers [ 55 ], while androgen receptors (AR) play a fundamental role in the development and survival of male reproductive tissues, such as the prostate [ 56 ]. Testosterone is the most abundant androgen in men [ 57 ]. Low testosterone levels lead to fatigue and erectile dysfunction, and high levels have been linked to a variety of diseases, particularly prostate cancer [ 57 ], which is the most common cancer among men [ 58 ].…”

Section: Introductionmentioning

confidence: 99%

“…Testosterone is the most abundant androgen in men [ 57 ]. Low testosterone levels lead to fatigue and erectile dysfunction, and high levels have been linked to a variety of diseases, particularly prostate cancer [ 57 ], which is the most common cancer among men [ 58 ]. PgR levels in breast tumors and AR in prostate tumors also provide important prognostic information for the detection and treatment of hormone-responsive neoplasms.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cell Uptake of Steroid-BODIPY Conjugates and Their Internalization Mechanisms: Cancer Theranostic Dyes

Amendoeira

Luz

Valente

et al. 2023

IJMS

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Estradiol-BODIPY linked via an 8-carbon spacer chain and 19-nortestosterone- and testosterone-BODIPY linked via an ethynyl spacer group were evaluated for cell uptake in the breast cancer cell lines MCF-7 and MDA-MB-231 and prostate cancer cell lines PC-3 and LNCaP, as well as in normal dermal fibroblasts, using fluorescence microscopy. The highest level of internalization was observed with 11β-OMe-estradiol-BODIPY 2 and 7α-Me-19-nortestosterone-BODIPY 4 towards cells expressing their specific receptors. Blocking experiments showed changes in non-specific cell uptake in the cancer and normal cells, which likely reflect differences in the lipophilicity of the conjugates. The internalization of the conjugates was shown to be an energy-dependent process that is likely mediated by clathrin- and caveolae-endocytosis. Studies using 2D co-cultures of cancer cells and normal fibroblasts showed that the conjugates are more selective towards cancer cells. Cell viability assays showed that the conjugates are non-toxic for cancer and/or normal cells. Visible light irradiation of cells incubated with estradiol-BODIPYs 1 and 2 and 7α-Me-19-nortestosterone-BODIPY 4 induced cell death, suggesting their potential for use as PDT agents.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cell Uptake of Steroid-BODIPY Conjugates and Their Internalization Mechanisms: Cancer Theranostic Dyes

Amendoeira

Luz

Valente

et al. 2023

IJMS

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Changes in post-transplant serum testosterone levels in men undergoing lung transplantation: a pilot study using the TriNetX Research Network

Thompson,

Omil-Lima,

Perez

et al. 2024

Int J Impot Res

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Hypogonadism is understudied in men requiring solid organ transplants, particularly among lung transplant recipients. Improvement in serum testosterone levels has been reported in kidney and liver transplantation. Using the TriNetX Research Network, we performed a retrospective cohort study to evaluate the incidence of peri-transplant hypogonadism and the natural course of serum testosterone following successful lung transplantation. Men aged ≥ 18 with a lung transplant and total testosterone drawn within one year pre- and post-transplant were included. Men with receipt of testosterone therapy were excluded. A low testosterone (<300 ng/dL) and normal testosterone (≥300 ng/dL) cohort was created before employing descriptive and analytic statistics to investigate the incidence of peri-transplant hypogonadism and the change in serum testosterone levels following lung transplantation. In our entire cohort, lung transplantation was not associated with a significant increase in post-transplant serum testosterone (329.86 ± 162.56 ng/dL pre-transplant and 355.13 ± 216.11 ng/dL post-transplant, p = 0.483). The number of men with low testosterone decreased by 9.8% following lung transplantation but was not significant, p = 0.404. In this pilot study, no significant change in the number of hypogonadal men nor serum testosterone levels was observed among men undergoing lung transplantation.

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An initial investigation into changes in post-transplant serum testosterone levels in men undergoing lung transplantation: what are the take aways?

Campbell

2024

Int J Impot Res

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Testosterone deficiency in male organ transplant recipients

Cited by 3 publications

References 72 publications

Cell Uptake of Steroid-BODIPY Conjugates and Their Internalization Mechanisms: Cancer Theranostic Dyes

Cell Uptake of Steroid-BODIPY Conjugates and Their Internalization Mechanisms: Cancer Theranostic Dyes

Changes in post-transplant serum testosterone levels in men undergoing lung transplantation: a pilot study using the TriNetX Research Network

An initial investigation into changes in post-transplant serum testosterone levels in men undergoing lung transplantation: what are the take aways?

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