Testosterone effects on pain and brain activation patterns

Choi, Jae Chan; Park, Y.-H.; Park, S. K.; Lee, J. S.; Kim, J.; Choi, Jun-Ho; Yoon, Kyung Bong; Lee, S.; Lim, Dae-Young; Choi, Jun-Ho; Kim, M. H.; Park, G.; Choi, S. S.; Lee, J.-M.

doi:10.1111/aas.12908

Cited by 26 publications

(7 citation statements)

References 34 publications

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“…However, some studies suggest that testosterone is necessary for a small nociceptive response (Thompson et al, 2008 ; Glaser et al, 2012 ; Schertzinger et al, 2017 ). According to these studies, low levels of testosterone are related to high discomfort, anxiety, and pain in response to noxious hot stimuli (Choi et al, 2017 ). In another study, Fanton et al ( 2017 ) concluded that the protective effect of testosterone is due to the activation of androgen receptors by the hormone instead of an androgenic action of a testosterone derivative (i.e., dihydrotestosterone) during CNS development.…”

Section: Trpv1 Trpm8 and Testosteronementioning

confidence: 99%

TRP Channels as Potential Targets for Sex-Related Differences in Migraine Pain

Artero-Morales

González-Rodríguez

Ferrer-Montiel

2018

Front. Mol. Biosci.

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Chronic pain is one of the most debilitating human diseases and represents a social and economic burden for our society. Great efforts are being made to understand the molecular and cellular mechanisms underlying the pathophysiology of pain transduction. It is particularly noteworthy that some types of chronic pain, such as migraine, display a remarkable sex dimorphism, being up to three times more prevalent in women than in men. This gender prevalence in migraine appears to be related to sex differences arising from both gonadal and genetic factors. Indeed, the functionality of the somatosensory, immune, and endothelial systems seems modulated by sex hormones, as well as by X-linked genes differentially expressed during development. Here, we review the current data on the modulation of the somatosensory system functionality by gonadal hormones. Although this is still an area that requires intense investigation, there is evidence suggesting a direct regulation of nociceptor activity by sex hormones at the transcriptional, translational, and functional levels. Data are being accumulated on the effect of sex hormones on TRP channels such as TRPV1 that make pivotal contributions to nociceptor excitability and sensitization in migraine and other chronic pain syndromes. These data suggest that modulation of TRP channels' expression and/or activity by gonadal hormones provide novel pathways for drug intervention that may be useful for targeting the sex dimorphism observed in migraine.

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Section: Trpv1 Trpm8 and Testosteronementioning

confidence: 99%

TRP Channels as Potential Targets for Sex-Related Differences in Migraine Pain

Artero-Morales

González-Rodríguez

Ferrer-Montiel

2018

Front. Mol. Biosci.

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“…The mechanism behind the found associations is that sex hormones are known to have a muting effect on the stress system [15]. For instance, men with higher levels of the sex hormone testosterone have lower levels of pain and fear [16], and for fear this was demonstrated also in male mice [17]. Extrapolation of these findings to male dogs would mean that castration-induced drops in testosterone levels raises fear levels.…”

Section: Introductionmentioning

confidence: 97%

Self-reports of Dutch dog owners on received professional advice, their opinions on castration and behavioural reasons for castrating male dogs

2020

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Male dogs are often castrated based on the thought that it facilitates well-behavedness. However, the causal evidence for this from prospective studies lacks and the existing associative studies present mixed results depending on the studied behaviours. We aimed to gain insight into possible factors driving an owner's decision to castrate their male dog, through a quantitative survey based on a convenience sample. We determined the advice owners received from three types of dog professionals (veterinarian practitioners, behavioural trainers, behavioural therapists) and the owners' assessments of castration's behavioural effects. Data on 491 Dutch owners of castrated and intact male dogs were analysed with Chi-square tests. Results indicate that owners of both castrated and intact dogs received castration advice most often from veterinarian practitioners, with pro-castration at higher frequencies for owners of castrated dogs (Chi-square, P<0.001). Overall, most owners disagreed with or were neutral about statements on castration positively affecting male dog behaviour at a population level. Nevertheless, 58% (N = 145) of the owners of castrated dogs (N = 249) reported that correcting unwanted behaviour was a reason to castrate their own male dog. Unwanted behaviour involved aggression in 50% (N = 70) of the owner-dog dyads. Castrated dog's aggression changes were reported on most as 'no change'. The second most common answer indicated an aggression decrease in dogs castrated to correct unwanted behaviour and an increase in dogs castrated for other reasons (Chi-square, P<0.001). The increase in aggression in a subset of castrated dogs is concerning, as aggression can pose risks to the dog's welfare. We acknowledge the limitations of our study which identifies associations rather than provides causal evidence. Still, we recommend professionals' awareness of possible negative behavioural changes following castration, like increased aggression. Future research on behavioural consequences of castrating dogs needs to build a more solid knowledge base for balanced advice regarding castration.

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“…This study used a between-subject design, with subjects assigned to either the positive experience group or the negative experience group; these groups were distinguished by a history of effective or ineffective treatment with the placebo analgesic cream. In our previous study 20 , there was a group difference between the strong placebo and control conditions to be 16.16 on a scale of pain score. The sample size required to have 80% power (i.e., β = 0.2) at α = 0.05 (SD = 20) can be obtained by normal approximation as n = [(Zα/2 + Zβ) × σ/µD] 2 ≈ 12 21 .…”

Section: Methodsmentioning

confidence: 86%

The increased analgesic efficacy of cold therapy after an unsuccessful analgesic experience is associated with inferior parietal lobule activation

Choi

Park²,

Kang

et al. 2022

Sci Rep

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Prior experiences of successful and failed treatments are known to influence the efficacy of a newly applied treatment. However, whether that carry-over effect applies to non-pharmacological treatments is unknown. This study investigated how a failed treatment history with placebo analgesic cream affected the therapeutic outcomes of cold-pack treatment. The neural correlates underlying those effects were also explored using functional magnetic resonance imaging. The effect of the placebo analgesic cream was induced using placebo conditioning with small (44.5 °C to 43.7 °C, negative experience) and large (44.5 °C to 40.0 °C, positive experience) thermal stimuli changes. After the placebo conditioning, brain responses and self-reported evaluations of the effect of subsequent treatment with a cold-pack were contrasted between the two groups. The negative experience group reported less pain and lower anxiety scores in the cold-pack condition than the positive experience group and exhibited significantly greater activation in the right inferior parietal lobule (IPL), which is known to be involved in pain relief. These findings suggest that an unsatisfying experience with an initial pain-relief treatment could increase the expectations for the complementary treatment outcome and improve the analgesic effect of the subsequent treatment. The IPL could be associated with this expectation-induced pain relief process.

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Testosterone effects on pain and brain activation patterns

Cited by 26 publications

References 34 publications

TRP Channels as Potential Targets for Sex-Related Differences in Migraine Pain

TRP Channels as Potential Targets for Sex-Related Differences in Migraine Pain

Self-reports of Dutch dog owners on received professional advice, their opinions on castration and behavioural reasons for castrating male dogs

The increased analgesic efficacy of cold therapy after an unsuccessful analgesic experience is associated with inferior parietal lobule activation

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