Testosterone for schizophrenia

Elias, Alby; Kumar, Ajit

doi:10.1002/14651858.cd006197

Cited by 1 publication

(1 citation statement)

References 15 publications

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“…Despite promising initial results (32, 33), a recent meta-analysis indicates an overall lack of efficacy of testosterone for negative symptoms (34). We did not replicate the association between the severity of negative symptoms and testosterone.…”

Section: Discussionmentioning

confidence: 99%

Testosterone in Newly Diagnosed, Antipsychotic-Naive Men With Nonaffective Psychosis

Fernández-Egea

García-Rizo

Miller

et al. 2011

Psychosomatic Medicine

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Objective Schizophrenia has been associated with age-related abnormalities, including abnormal glucose tolerance, increased pulse pressure, increased inflammation, abnormal stem cell signalling and shorter telomere length. These metabolic abnormalities as well as other findings suggest schizophrenia and related disorders might be associated with accelerated aging. Testosterone activity has a progressive decline with increasing age. Methods We tested the hypothesis that circulating biologically active testosterone is lower in newly diagnosed, antipsychotic-naïve male patients with nonaffective psychosis than in matched control subjects. Results Patients (n=33) were matched to control subjects (n=33) for age, gender, body mass index, socioeconomic status of the family of origin, and smoking. The free androgen index (FAI), a measure of biologically active testosterone, was significantly lower in the psychosis group [mean 57.7%, SD=26.1] than in control subjects [71.6%, 27.0; p=0.04], with an effect size of 0.53. Multivariate analysis also supported the findings. In the psychosis group, FAI had a significant negative correlation with the conceptual disorganization item (r=-0.35, p=0.049), but not with reality distortion (r=-0.21; p=0.24), negative symptoms (r=0.004; p=0.98) or depression (r=-0.014; p=0.94). Conclusion Lower testosterone is consistent with accelerated aging in nonaffective psychosis, but further testing of this hypothesis is needed.

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Section: Discussionmentioning

confidence: 99%