Testosterone in the control of rat sexual behavior

Södersten, P.; Hansen, Stefan; Eneroth, P.; Wilson, Catherine; Gustafsson, Jan‐Åke

doi:10.1016/0022-4731(80)90289-7

Cited by 26 publications

(18 citation statements)

References 72 publications

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“…Further assessment of the effect of LBP on male sexual behavior is warranted in the future. Under normal physiological conditions, serum T, LH, FSH, and E 2 levels in male testes are well balanced (Soderstein et al, 1980;Engelking, 2000). One to three days after castration, major sexual hormone levels decrease and E 2 level increases significantly.…”

Section: Discussionmentioning

confidence: 98%

Lycium barbarum polysaccharides: Protective effects against heat-induced damage of rat testes and H2O2-induced DNA damage in mouse testicular cells and beneficial effect on sexual behavior and reproductive function of hemicastrated rats

et al. 2006

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Section: Discussionmentioning

confidence: 98%

Lycium barbarum polysaccharides: Protective effects against heat-induced damage of rat testes and H2O2-induced DNA damage in mouse testicular cells and beneficial effect on sexual behavior and reproductive function of hemicastrated rats

et al. 2006

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“…There is another rise between days 5 and 15 after castration (Badger, Wilcox, Meyer et al 1978;Caraty, de Reviers, Martinat & Blanc, 1981 ) and a further rise after day 30 (Howland & Skinner, 1975;Södersten, Hansen, Eneroth et al 1980;Linkie, Furth & Kourelakos, 1981). Plasma follicle-stimulating hormone (FSH) levels also rise within 24 h and continue to increase at a steady rate until day 8, and at a slower rate until day 30 (Ojeda & (Howland & Skinner, 1975;Linkie et al 1981).…”

Section: Introductionmentioning

confidence: 95%

Studies on the control of gonadotrophin release in the gonadectomized male rat: evidence for a lack of involvement of the hypothalamic noradrenergic system in the long-term castrated rat

Herdon¹,

Everard²,

Wilson³

1984

Journal of Endocrinology

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The effects of castration with or without testosterone replacement in the adult male rat were studied to investigate possible hypothalamic mechanisms by which changes in gonadotrophin secretion occur at different times after castration, with particular reference to the continuing LH rise and its lack of suppression by testosterone in the long-term castrated rat. Castrated rats received either subcutaneous silicone elastomer implants containing testosterone or empty implants at the time of castration, and a sham-operated group served as controls. At 1, 10 and 40 days after castration, there were six-, 15- and 25-fold rises respectively in LH and 1.5-, two- and fivefold rises in FSH. However, there were no significant changes in hypothalamic noradrenaline concentration and turnover or in alpha-adrenoceptor density and affinity at any time after castration. Testosterone implants were effective in suppressing gonadotrophin release at 1 and 10 days, but not at 40 days after castration, and did not significantly affect hypothalamic noradrenaline turnover or alpha-adrenoceptors at any time. Neither acute inhibition of the noradrenergic system, using either the alpha-adrenoceptor blockers phenoxybenzamine and phentolamine or the synthesis inhibitor alpha-methyl-p-tyrosine, nor chronic depletion of hypothalamic noradrenaline by 6-hydroxydopamine had any significant effect on the normal rise in LH levels seen on days 10 and 40 after castration, and did not alter the ability of testosterone to suppress LH levels. This indicates that, in the long-term castrated rat, the noradrenergic system may not be involved in the control of gonadotrophin release. However, at 16 h after castration, alpha-adrenoceptor blockers and alpha-methyl-p-tyrosine did reduce LH levels, indicating that the noradrenergic system is likely to be involved in the short-term response to castration.

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“…High levels of T on the day of birth masculinize and defeminize adult sexual behaviors in rodents [8,9]. However, as discussed previously, many of the physiological actions of T are due to aromatization of T to E. Estradiol treatment of males during the first 10 days of life led to increased frequency of intromissions and ejaculation in T-treated adult castrates compared to males treated neonatally with T [13,112]. Interestingly, females treated with T during the prenatal and neonatal period and T in adulthood will display masculine copulatory behaviors (e.g., mounting) and fewer feminine behaviors than normal females [113,114].…”

Section: Development Of Reproductive Behaviormentioning

confidence: 88%

“…In adult male rats that were castrated and treated with either T or E, no differences were found in the number of mounts or intromissions. Interestingly, rats receiving T ejaculated more frequently than those treated with E [13,14]. These findings suggest that while E does not elicit full male sexual behavior alone, many of the effects of T on brain and behavior are mediated by its conversion to E.…”

mentioning

confidence: 84%

Nuclear Receptor Coactivator Function in Reproductive Physiology and Behavior1

Molenda

Kilts

Allen

et al. 2003

Biology of Reproduction

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Gonadal steroid hormones act throughout the body to elicit changes in gene expression that result in profound effects on reproductive physiology and behavior. Steroid hormones exert many of these effects by binding to their respective intracellular receptors, which are members of a nuclear receptor superfamily of transcriptional activators. A variety of in vitro studies indicate that nuclear receptor coactivators are required for efficient transcriptional activity of steroid receptors. Many of these coactivators are found in a variety of steroid hormone-responsive reproductive tissues, including the reproductive tract, mammary gland, and brain. While many nuclear receptor coactivators have been investigated in vitro, we are only now beginning to understand their function in reproductive physiology and behavior. In this review, we discuss the general mechanisms of action of nuclear receptor coactivators in steroid-dependent gene transcription. We then review some recent and exciting findings on the function of nuclear receptor coactivators in steroid-dependent brain development and reproductive physiology and behavior.

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Testosterone in the control of rat sexual behavior

Cited by 26 publications

References 72 publications

Lycium barbarum polysaccharides: Protective effects against heat-induced damage of rat testes and H2O2-induced DNA damage in mouse testicular cells and beneficial effect on sexual behavior and reproductive function of hemicastrated rats

Lycium barbarum polysaccharides: Protective effects against heat-induced damage of rat testes and H2O2-induced DNA damage in mouse testicular cells and beneficial effect on sexual behavior and reproductive function of hemicastrated rats

Studies on the control of gonadotrophin release in the gonadectomized male rat: evidence for a lack of involvement of the hypothalamic noradrenergic system in the long-term castrated rat

Nuclear Receptor Coactivator Function in Reproductive Physiology and Behavior1

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