Testosterone is related to GABA+ levels in the posterior-cingulate in unmedicated depressed women during reproductive life

Flores‐Ramos, Mónica; Alcauter, Sarael; Lopez-Titla, Maria Margarita; Bernal-Santamaría, Norma; Calva-Coraza, Edgar; Edden, Richard A.E.

doi:10.1016/j.jad.2018.08.033

Cited by 17 publications

(12 citation statements)

References 63 publications

(73 reference statements)

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“…The literature has reported contradictory results in this regard (Celec, Ostatníková, & Hodosy, 2015). However, in a previous study, we found that testosterone has a potentially anxiolytic and anti-depressant effect, increasing GABA+ levels in the posterior cortex of the cingulum (Flores-Ramos et al, 2019). Conversely, several studies have documented the effect of testosterone on modulating insulin resistance.…”

Section: Introductionmentioning

confidence: 71%

“…At the same time, their anxiolytic and antidepressant effect could be explained through the modulation of GABAergic receptors. In young women, a direct relationship between testosterone levels and GABAergic concentrations in the posterior cingulum, measured through spectroscopy (Flores-Ramos et al, 2019), has been observed. Lastly, Carrier and colleagues propose that the antidepressant effect of testosterone includes its ability to become estradiol at the central level and thus reduce depressive symptoms (Carrier et al, 2015).…”

Section: Discussionmentioning

confidence: 97%

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Evaluation of hormonal and metabolic factors related to depression in reproductive age women

et al. 2020

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Introduction. Major depressive disorder (MDD) is a prevalent disease affecting women more than men worldwide. Various factors are involved in the genesis of depression, including hormones such as testosterone and certain metabolic factors Objective. To evaluate hormone levels and metabolic variables in women with major depression and healthy controls. Method. A cross-sectional, comparative analytical study was conducted in 40 participants, 23 patients with an MDD diagnosis and 17 controls, all of women in reproductive age between the ages of 18 and 45. Sociodemographic variables, hormonal profile, and metabolic variables were assessed and the 17-item Hamilton Depression Scale was used to evaluate depressive symptoms. Results. No statistically significant differences were observed between the groups in the hormonal and metabolic variables explored. Nevertheless, it was observed that the lower the testosterone levels and the higher the serum glucose levels, the more intense depressive symptoms were. Discussion and conclusion. Testosterone is associated with a lower depressive symptoms score on the Hamilton Depression scale, suggesting a potential antidepressant effect, whereas high glucose levels are associated with a higher score on this scale. We believe that the measurement of hormonal and metabolic variables in women can contribute to a better understanding of the pathophysiology of depression.

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Section: Introductionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 97%

Evaluation of hormonal and metabolic factors related to depression in reproductive age women

et al. 2020

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“…First, to maintain anatomical specificity, a smaller voxel is required - we chose 15.625 mL relative to a typical 27 mL used in adults- and the GABA+ concentration is lower, i.e. the measured ACC neonatal GABA+ concentration is 0.16 mM versus reported 1.72 mM in adults ( Flores-Ramos et al., 2019 ). Another factor is the effect of random neonatal motion, likely responsible for an average measured frequency offset change of ~ 0.03 ppm, which is higher than most of the adult values reported for Philips scanners benefitting from frequency correction during data acquisition ( Mikkelsen et al., 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Simultaneous quantification of GABA, Glx and GSH in the neonatal human brain using magnetic resonance spectroscopy

et al. 2021

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Highlights First simultaneous measurement of GABA+, Glx and GSH in the neonatal human brain. Robust metabolic estimation in neonates requires a specific quantification strategy. GABA+ has a doublet peak in neonates indicating lower macromolecular contributions. Future application can inform about pathophysiology in neurodevelopment.

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“…As such, the neurochemical link between FD-PDS and MDD remains elusive. In measuring GABA concentrations, we used MEGAPRESS which is the standard tool in resolving GABA and with which significant differences had been detected in the DLFPC, pgACC, insula, and somatosensory cortices in (52) patients with various psychiatric conditions using comparable parameters (53)(54)(55)(56). We only included subjects with good spectral quality into the analysis; therefore, poor spectral quality, which would have ensued from poor voxel placement, was unlikely to explain the unequivocal findings.…”

Section: Discussionmentioning

confidence: 99%

Unaltered Brain GABA Concentrations and Resting fMRI Activity in Functional Dyspepsia With and Without Comorbid Depression

Mak

Leung

et al. 2020

Front. Psychiatry

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Background: GABA-deficit characterizes depression (MDD), which is highly comorbid with Functional Dyspepsia (FD). We examined brain GABA concentrations and resting activities in post-prandial distress subtype FD (FD-PDS) patients with and without MDD. Methods: 24 female age/education-matched FD-PDS with comorbid MDD (FD-PDS-MDD), non-depressed FD-PDS, and healthy controls each were compared on GABA concentrations, resting fMRI (fALFF) in bilateral pregenual anterior cingulate (pgACC), left dorsolateral prefrontal cortex (DLPFC), insula, and somatosensory cortex (SSC). Results: FD-PDS-MDD patients had mild though elevated depressive symptoms. FD-PDS patients had generally mild dyspeptic symptoms. No significant between-group differences in GABA or fALFF were found. No significant correlations were found between GABA and depressive/dyspeptic symptoms after Bonferroni correction. In patients, GABA correlated positively with left insula fALFF (r = 0.38, Bonferroni-corrected p = .03). Conclusion: We did not find altered GABA concentrations or brain resting activity in FD-PDS or its MDD comorbidity. The neurochemical link between MDD and FD remains elusive.

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Testosterone is related to GABA+ levels in the posterior-cingulate in unmedicated depressed women during reproductive life

Abstract: Our findings suggest that the potential anxiolytic and antidepressant properties of T are related to increased GABA+ levels in the PCC. This observation may contribute to increased understanding of the role of T in depressive and anxiety symptoms in women.

Cited by 17 publications

References 63 publications

Evaluation of hormonal and metabolic factors related to depression in reproductive age women

Evaluation of hormonal and metabolic factors related to depression in reproductive age women

Simultaneous quantification of GABA, Glx and GSH in the neonatal human brain using magnetic resonance spectroscopy

Unaltered Brain GABA Concentrations and Resting fMRI Activity in Functional Dyspepsia With and Without Comorbid Depression

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