Testosterone Levels and Bone Mineral Density in Healthy Elderly Men

Morán, José María Tovillas; Lavado‐García, Jesus M.; Roncero-Martín, Raúl; Pedrera-Canal, María; Vera, Vincente; Fernandez, Pilar; Pedrera‐Zamorano, Juan D.

doi:10.1111/jgs.13208

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…Previous research showed that higher testosterone was associated with higher BMD and decreased fracture risk. 29 , 30 Mellstrom et al found free testosterone (FT) is an independent predictor of BMD and prevalent fractures in elderly Swedish males. 10 Xia Jin-wei et al founded that the ratio of E2/ testosterone of the type 2 diabetes group was significantly increased, whereas testosterone was obviously decreased compared with healthy people.…”

Section: Discussionmentioning

confidence: 99%

Association of Plasma Sex-Related Hormones Levels with Bone Mineral Densities and Risk of Osteoporosis and Osteopenia in Men and Menopausal Women with Type 2 Diabetes Mellitus

Lü¹,

Zheng²,

Zhou³

et al. 2023

DMSO

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Objective This study aimed to examine associations between plasma sex-related hormones with bone mineral density (BMD) and risks of osteoporosis or osteopenia in men and postmenopausal women patients with type 2 diabetes mellitus (T2DM). Methods Baseline information on an ongoing cohort of 149 men and 102 postmenopausal women with T2DM in Xiamen, China were analyzed. Plasma estradiol (E2), total testosterone (T), follicle-stimulating hormone (FSH), luteinizing hormone (LH) and prolactin (PRL) were measured. BMD of lumbar spine (L2-4), femoral neck (FN) and total hip (TH) were determined by dual-energy X-ray absorptiometry (DXA). Osteoporosis or osteopenia was defined as the minimum T-scores of BMD of these three different sites of −1.0 or below. Results T2DM patients with osteoporosis/osteopenia (66.4% in men and 79.4% in postmenopausal women), compared to those without, showed significantly decreased level of E2 (75.3±28.9 vs. 107.8±25.9pmol/L and 18.4 (18.4–29.5) vs. 22.8 (18.4–40.5) pmol/L for men and postmenopausal women, respectively, both p-values <0.05), but not other sex-related hormones (including T, FSH, LH, or PRL). For all T2DM patients together and men separately, multivariable linear regression and logistic regression analyses showed that higher E2 levels were significantly associated with higher BMD T-scores in L2-4, FN, TH and minimum of these three different sites, lower 10-year probability of major osteoporotic fractures (MOF) and hip fractures (HFs) estimated by Fracture Risk Assessment Tool score, as well as decreased risk of osteoporosis/osteopenia. As for postmenopausal women T2DM patients, E2 level was positively associated with BMD T-scores in L2-4 and minimum of three different sites but was not independently associated with risk of osteoporosis/osteopenia. Conclusion Higher plasma E2 was significantly associated with increased BMD and lower risk of osteoporosis or osteopenia in T2DM patients, especially for men. Screening of BMD and estradiol levels as well as evaluating risks of osteoporosis/osteopenia are important for T2DM patients.

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Section: Discussionmentioning

confidence: 99%

Association of Plasma Sex-Related Hormones Levels with Bone Mineral Densities and Risk of Osteoporosis and Osteopenia in Men and Menopausal Women with Type 2 Diabetes Mellitus

Lü¹,

Zheng²,

Zhou³

et al. 2023

DMSO

View full text Add to dashboard Cite

show abstract

“…Men who are completely deficient in testosterone are more likely to lose bone rapidly. It may be clinically necessary to detect BMD in elderly men with sex hormone deficiency [ 4 , 5 ].Moreover, increasing evidence supported that there is a strong link between testosterone concentration and bone mineral density [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Association of total testosterone status with bone mineral density in adults aged 40–60 years

Wang

Huang

2021

J Orthop Surg Res

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Objective Evidence linking total testosterone and bone mineral density (BMD) in adults is very limited. According to our review of the literature, only a few reports have focused on the relationship between total testosterone and bone mineral density in adults. Therefore, the purpose of this study was to determine the relationship between total testosterone and total bone mineral density in adults aged 40–60 years. Methods We used a cross-sectional study of a non-institutionalized U.S. population sample from the National Health and Nutrition Examination Survey. A weighted multivariate linear regression model was used to evaluate the relationship between total testosterone and total bone mineral density. Subgroup analyses were further performed. Results In multiple regression models adjusted for potential confounders, total testosterone levels were inversely associated with total bone mineral density. However, in the sex-stratified subgroup analysis, the association between total testosterone levels and total bone mineral density was not significant in female adolescents. There was no negative association between total testosterone and total BMD among men, adults 40 to 60 years of age, and other racial/ethnic groups. There is a negative association between total testosterone and total bone mineral density when total testosterone concentration is greater than 500 ng/dL among Non-Hispanic black. Conclusion Our statistical results show that the association between total testosterone levels and total bone mineral density varies by gender and race. Elevated total testosterone levels below 500 ng/dL have adverse effects on bone health. Total testosterone concentrations below 500 ng/dL may have no effect on bone health.

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Spine Injections for Persistent Lumbar and Radicular Pain After Lumbar Spine Surgery

Wolfer

Derby

Lee

2016

Advanced Concepts in Lumbar Degenerative Disk Disease

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Testosterone Levels and Bone Mineral Density in Healthy Elderly Men

Cited by 3 publications

References 7 publications

Association of Plasma Sex-Related Hormones Levels with Bone Mineral Densities and Risk of Osteoporosis and Osteopenia in Men and Menopausal Women with Type 2 Diabetes Mellitus

Association of Plasma Sex-Related Hormones Levels with Bone Mineral Densities and Risk of Osteoporosis and Osteopenia in Men and Menopausal Women with Type 2 Diabetes Mellitus

Association of total testosterone status with bone mineral density in adults aged 40–60 years

Spine Injections for Persistent Lumbar and Radicular Pain After Lumbar Spine Surgery

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