Testosterone modulates spatial recognition memory in male rats

Hawley, Wayne R.; Grissom, Elin M.; Martin, Ryan C.; Halmos, Miklós B.; Bart, Corrine L.S.; Dohanich, Gary P.

doi:10.1016/j.yhbeh.2013.02.007

Cited by 52 publications

(52 citation statements)

References 92 publications

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“…Castrated males given treated with normal to supraphysiological levels of testosterone produced fewer errors on this task (206,348), whereas males treated with estradiol (5 mm capsule) learned the task faster than other groups. Utilizing a delayed nonmatch to place strategy, Hawley et al (257) examined spatial working memory in the Y maze in males castrated and implanted with capsules that produced low or normal physiological levels of testosterone. Memory retention was only facilitated in males systemically treated with physiological levels of testosterone if the delay was extended to 48 hours; shorter delays did not reveal a difference between the testosterone or vehicle treated groups.…”

Section: Spatial Reference Memorymentioning

confidence: 99%

Sex Hormones and Cognition: Neuroendocrine Influences on Memory and Learning

Hamson

Roes

Galea

2016

Comprehensive Physiology

173

110

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Sex differences in neurological disease exist in incidence, severity, progression, and symptoms and may ultimately influence treatment. Cognitive disturbances are frequent in neuropsychiatric disease with men showing greater cognitive impairment in schizophrenia, but women showing more severe dementia and cognitive decline with Alzheimer's disease. Although there are no overall differences in intelligence between the sexes, men, and women demonstrate slight but consistent differences in a number of cognitive domains. These include a male advantage, on average, in some types of spatial abilities and a female advantage on some measures of verbal fluency and memory. Sex differences in traits or behaviors generally indicate the involvement of sex hormones, such as androgens and estrogens. We review the literature on whether adult levels of testosterone and estradiol influence spatial ability in both males and females from rodent models to humans. We also include information on estrogens and their ability to modulate verbal memory in men and women. Estrone and progestins are common components of hormone therapies, and we also review the existing literature concerning their effects on cognition. We also review the sex differences in the hippocampus and prefrontal cortex as they relate to cognitive performance in both rodents and humans. There has been greater recognition in the scientific literature that it is important to study both sexes and also to analyze study findings with sex as a variable. Only by examining these sex differences can we progress to finding treatments that will improve the cognitive health of both men and women. © 2016 American Physiological Society. Compr Physiol 6:1295-1337, 2016.

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Section: Spatial Reference Memorymentioning

confidence: 99%

Sex Hormones and Cognition: Neuroendocrine Influences on Memory and Learning

Hamson

Roes

Galea

2016

Comprehensive Physiology

173

110

View full text Add to dashboard Cite

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“…In 411 the rat, maternal UN has sex-specific effects on cognition [84], and these may in part be due to 412 interactions with sex steroids. Sex hormones, particularly testosterone, affect behavioural stress 413 responses in sheep [177,178], whereas in rats both oestrogen and testosterone appear to 414 independently affect both stress response and spatial learning [179][180][181][182]. Therefore studies utilising 415 one sex or pre-pubertal animals are unlikely to produce data applicable to human adults.…”

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confidence: 99%

Programming the brain: Common outcomes and gaps in knowledge from animal studies of IUGR

Hunter

Hazel

Kind

et al. 2016

Physiology & Behavior

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“…On the one hand, some studies have shown that testosterone depletion or administration does not affect learning and memory 31 ; on the other hand, several studies have indicated that androgens impaired 32,33 or enhanced spatial learning and memory 34,35 . Hawley, in 2013, showed that cognitive memory in castrated rats had no significant difference compared with the rats receiving testosterone after the surgery 36 . Recent studies in adult male rats have found modulatory roles for sex steroids on cognitive and functional memory and other types of cognitive tasks that are sensitive to neural disorders 37 .…”

Section: Discussionmentioning

confidence: 99%

Effect of Testosterone on Memory and BDNF Levels of Hippocampus in Gonadectomized Diabetic Rats

Ebrahimzadeh¹,

Shahabi²,

Mohaddes³

et al. 2015

Biosci., Biotech. Res. Asia

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The prevalence of cognitive impairment in diabetic patients is more than in non-diabetic ones. BDNF and sex hormones levels play important roles in learning and memory. In this study, the effect of testosterone on BDNF expression and memory was investigated in 60 male Wistar rats were randomly divided into 6 groups (n=10): control (C), Diabetic (Dia), Diabetic-Sham (Sh), Diabetic-Gonadectomized (Dia-Gdx), DiabeticTestosterone (Dia-T), and Diabetic-Gonadectomized-Testosterone (Dia-Gdx-T). Diabetes was induced by STZ (60mg/Kg). Testosterone (2mg/kg/day) was administered intraperitoneally for 6 weeks. The BDNF levels in the hippocampus were assessed by ELISA kit. Novel object recognition (NOR) test was performed for the investigation of recognition memory. Induction of diabetes did not significantly change the BDNF levels of hippocampus, where as Gonadectomy or testosterone administration in diabetic animal's significantly reduced BDNF levels. Short-term memory significantly was reduced in Dia-Gdx, Dia-T, and Dia-Gdx-T groups compared to the control group; however, Gonadectomy or testosterone therapy had no significant effects on it in diabetic rats. BDNF levels and short-term memory decreased in diabetic groups that received or were depleted from testosterone. It is possible that decrease of BDNF gene expression in the hippocampus caused a short-term memory disturbance.

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Testosterone modulates spatial recognition memory in male rats

Cited by 52 publications

References 92 publications

Sex Hormones and Cognition: Neuroendocrine Influences on Memory and Learning

Sex Hormones and Cognition: Neuroendocrine Influences on Memory and Learning

Programming the brain: Common outcomes and gaps in knowledge from animal studies of IUGR

Effect of Testosterone on Memory and BDNF Levels of Hippocampus in Gonadectomized Diabetic Rats

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