2007
DOI: 10.1093/humrep/dem009
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Testosterone patch improves ovarian follicular response to gonadotrophins in a patient with Kallmann's syndrome: A Case Report

Abstract: Achieving ovulation in women with Kallmann's syndrome requires both exogenous FSH and LH to successfully stimulate follicular maturation and ovarian steroidogenesis. We present a case of a woman with Kallmann's syndrome, who had poor ovarian response to stimulation by exogenous gonadotrophins. When she was given testosterone by patch before initiation of gonadotrophins, her stimulation dramatically improved. Once we ceased to pretreat her cycle with testosterone, she again had a poor stimulation. This suggests… Show more

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Cited by 6 publications
(4 citation statements)
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“…Sipe and Van Voorhis reported improved follicular response of gonadotropin stimulation after T patch administration in a single case of Kallmann's syndrome [79]. The same group, however, reported in a small prospectively randomized, placebo-controlled cross-over study no effects from short-term (12-day) transdermal T supplementation [80].…”
Section: Introductionmentioning
confidence: 99%
“…Sipe and Van Voorhis reported improved follicular response of gonadotropin stimulation after T patch administration in a single case of Kallmann's syndrome [79]. The same group, however, reported in a small prospectively randomized, placebo-controlled cross-over study no effects from short-term (12-day) transdermal T supplementation [80].…”
Section: Introductionmentioning
confidence: 99%
“…Ten manuscripts were selected during the initial screening. By examination of the full text, seven studies were excluded: one was a prospective self-controlled study ( 13 ), one was a duplicate study ( 14 , 15 ), three were clinical reviews ( 16 18 ), one was a case report ( 19 ) and one included females not undergoing IVF/ICSI ( 20 ). The flow chart for selection of the studies included is given in Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Kallmann syndrome is a rare genetic disorder characterized by hypogonadotropic hypogonadism and anosmia which affects approximately 1 in 50,000 women and 1 in 10,000 men. Induction of ovulation is difficult for women with Kallmann syndrome because few growing follicles are observed [1,2]. This is, in part, a result of the inability to synthesize gonadotropin-releasing hormone (GnRH), because of the genetic abnormalities associated with the disease.…”
Section: Introductionmentioning
confidence: 99%