Testosterone's Analgesic, Anxiolytic, and Cognitive-Enhancing Effects May Be Due in Part to Actions of Its 5α-Reduced Metabolites in the Hippocampus.

Edinger, Kassandra L.; Frye, Cheryl A.

doi:10.1037/0735-7044.118.6.1352

Cited by 147 publications

(117 citation statements)

References 88 publications

Supporting

Mentioning

109

Contrasting

Order By: Relevance

“…The lack of findings on pain sensitivity is somewhat surprising because previous studies have found that testosterone levels do relate to pain sensitivity and anxiety [42,43]. Interestingly, low levels of testosterone have been shown to enhance the fear response as measured by freezing and fear-induced analgesia [44], suggesting the possibility that the ET animals in the current study may show reduced aggression because of enhanced fear.…”

Section: Discussioncontrasting

confidence: 47%

“…However, the observed weight reduction is due to ethanol exposure during the second half of gestation [22] and is not a result of undernutrition since there are no body weight differences across dam groups. Thus, dissociating the effect of ethanol on the development of the body from that on the brain is not possible at least in an in vivo model.The lack of findings on pain sensitivity is somewhat surprising because previous studies have found that testosterone levels do relate to pain sensitivity and anxiety [42,43]. Interestingly, low levels of testosterone have been shown to enhance the fear response as measured by freezing and fear-induced analgesia [44], suggesting the possibility that the ET animals in the current study may show reduced aggression because of enhanced fear.…”

contrasting

confidence: 47%

See 1 more Smart Citation

Ethanol exposure during development reduces resident aggression and testosterone in rats

Lugo

Marino

Gass

et al. 2006

Physiology & Behavior

View full text Add to dashboard Cite

Ethanol exposure during development has been shown to alter social behaviors in people, but the range of deficits is not clear. Using an animal model of Fetal Alcohol Spectrum Disorders, intermale aggression and testosterone levels were examined in adult rats. Rats were exposed to ethanol during the entire prenatal period and from postnatal day 2 through 10. Ethanol was administered via intragastric intubation. Two other groups consisted of a nontreated control and an intubated control group that was exposed to the administration procedures but not ethanol. Both offensive and defensive aggression were examined in experimental residents and intruders under three different housing conditions for the resident males: (1) with another male, (2) with a pregnant female, and (3) with a female and litter fathered by the experimental animal. When housed with a female and litter, ethanol-exposed rats displayed reduced offensive aggression compared to control groups under the same condition. Defensive aggression in the non-experimental intruders was reduced in this same condition. There were no differences in duration of non-aggressive social behaviors among the groups in any of the housing conditions. Testosterone levels were reduced in ethanol-exposed rats compared to controls. In summary, ethanol exposure over the combined prenatal and postnatal periods reduces aggressive behavior in a condition where aggressive behavior is normally seen. This reduction may be related to lower testosterone levels. KeywordsFetal alcohol syndrome; Aggression; Resident-intruder paradigm; Social behavior; Prenatal alcohol Fetal Alcohol Spectrum Disorders (FASD) describes those individuals who manifest mild to severe disturbances of physical, behavioral, emotional, and/or social functioning due to in utero ethanol exposure. FASD individuals are found to commit high rate of crimes against others, engage in inappropriate sexual behavior, and are described as having a failure to consider the consequences of their actions [1,2]. Even though FASD individuals show high rates of crime, no direct measures of aggressive behaviors or testosterone in FAS individuals have been conducted. [3][4][5][6]; ethanol exposure from gestation day (GD) 6 to 19 increases offensive aggression in rats [7]. Ethanol exposure during the last four days of pregnancy and from postnatal day (PD) 1 to PD 4 increases aggression, while ethanol exposure confined to the period from PD 1 to 4 did not affect aggressive behavior in mice [8]. However, another study found that ethanol exposure from birth until PD 14 decreases aggression in mice [6]. These studies suggest that prenatal ethanol exposure may increase aggression, while postnatal ethanol exposure may decrease aggression. However, many of the early studies used ethanol administration procedures that were confounded by nutritional effects [4][5][6]8] or resulted in minimal transfer of ethanol to the pup [6]. The effect of ethanol exposure during the entire gestation period and during early postnatal development (i.e...

show abstract

Section: Discussioncontrasting

confidence: 47%

contrasting

confidence: 47%

Ethanol exposure during development reduces resident aggression and testosterone in rats

Lugo

Marino

Gass

et al. 2006

Physiology & Behavior

View full text Add to dashboard Cite

show abstract

“…Edinger and Fry [74] further found that systemically administered testosterone, dihydrotestosterone, or 3α-androstanediol all increased analgesia in the tail flick and paw lick paradigms. When administered intrahippocampally, these three steroids were also analgesic in the tail flick paradigm but only testosterone and 3α-androstanediol were analgesic in the paw lick paradigm.…”

Section: Analgesiamentioning

confidence: 99%

Reflexive testosterone release: A model system for studying the nongenomic effects of testosterone upon male behavior

Nyby

2008

Frontiers in Neuroendocrinology

100

View full text Add to dashboard Cite

Male mammals of many species exhibit reflexive testosterone release in mating situations. In house mice (Mus musculus), the dramatic robustness of such release, occurring primarily in response to a novel female, suggests some function. The resulting testosterone elevations typically peak during copulatory behavior and may serve to activate transitory motivational and physiological responses that facilitate reproduction. However, such a function requires that testosterone be working through either nongenomic, or very quick genomic, mechanisms. The first part of the review describes reflexive sex hormone release in house mice. The second part summarizes research implicating testosterone's fast actions in affecting anxiety, reward, learning, analgesia, and penile reflexes in rodents, all of which could optimize male mating success. The review concludes with a speculative model of how spontaneous and reflexive hormone release might interact to regulate reproductive behavior and why mice appear to be an ideal species for examining testosterone's quick effects.

show abstract

“…Metabolic syndromes may have a correlation with anxiety and depression, but its nature is unclear (6). Among all behavioral parameters, anxiety is thought to be most sensitive to testosterone and this hormone is either endogenous or exogenous and has been reported to have anxiolytic effect in the elevated plus maze (EPM) test (7,8). In addition, gonadectomy (GDX) results in anxiety-like behavior in male rats and increased exhibition of signs of anxiety in open field test (OFT) and EPM test (8).…”

Section: Introductionmentioning

confidence: 99%

“…Among all behavioral parameters, anxiety is thought to be most sensitive to testosterone and this hormone is either endogenous or exogenous and has been reported to have anxiolytic effect in the elevated plus maze (EPM) test (7,8). In addition, gonadectomy (GDX) results in anxiety-like behavior in male rats and increased exhibition of signs of anxiety in open field test (OFT) and EPM test (8). The genus Pistacia belongs to the Anacardiaceae family, and the most popular species of pistacia are Pistacia lentiscus, P. atlantica Desf., P. terebinthus L., P. vera L., and P. khinjuk Stock.…”

Section: Introductionmentioning

confidence: 99%

Anxiolytic-like effect of Pistacia atlantica fruit in intact and gonadectomized rats subjected to chronic stress

Rashidi

Askari

Abbasnejad

2014

JOHE

View full text Add to dashboard Cite

Received: November 2015, Accepted: December 2015 Background: Testosterone level in men decreases with aging (andropause) and androgen deficiency is responsible for a variety of behavioral symptoms such as anxiety. The aim of this study was to investigate the effect of Pistacia atlantica (bane) fruit extract on anxiety-like behavior in intact and gonadectomized rats. Materials and Methods: In this study, adult male rats were divided into two groups of intact and gonadectomized rats. The rats were submitted to a chronic unpredictable stress (CUS) paradigm, and subdivided into treated or nontreated groups (100 mg/kg of bane extract orally daily for 20 days). Anxiety-like behavior was evaluated using the elevated plus maze (EPM) test. Results: Bane treatment increased the percentage of both time spent and entries in the open arms of EPM in intact and gonadectomized rats. Additionally, the effects of chronic stress were reversed by bane treatment; the percentages of entries and time spent in the open arms decreased in intact and gonadectomized chronically stressed rats. Conclusions: These results suggest that P. atlantica may have some anxiolytic-like properties in castrated and intact rats.

show abstract

Testosterone's Analgesic, Anxiolytic, and Cognitive-Enhancing Effects May Be Due in Part to Actions of Its 5α-Reduced Metabolites in the Hippocampus.

Cited by 147 publications

References 88 publications

Ethanol exposure during development reduces resident aggression and testosterone in rats

Ethanol exposure during development reduces resident aggression and testosterone in rats

Reflexive testosterone release: A model system for studying the nongenomic effects of testosterone upon male behavior

Anxiolytic-like effect of Pistacia atlantica fruit in intact and gonadectomized rats subjected to chronic stress

Contact Info

Product

Resources

About