Testosterone supplementation in men with sexual dysfunction

Jung, Jae Hung; Kim, Hong Wook; Narayan, Vikram M.; Reddy, Balaji; Walsh, Thomas; Yu, Ho Song; Lim, Jung Soo; Kim, Myung Ha; Dahm, Philipp

doi:10.1002/14651858.cd013071

Cited by 3 publications

(2 citation statements)

References 72 publications

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“…Another example, in men with late onset sexual dysfunction and low levels of serum testosterone, the endogenous sex hormone testosterone has been used as a supplement (TST) for more than 70 years [30]. However, during the last decades reports have addressed the risks of polycythemia and hyperestrogenism in men treated with TST and prompted the need for a Cochrane review, that is currently ongoing [31]. Other commonly known examples of when endogenous substances have unwanted or serious side effects when taken at higher doses are, endogenous steroids, and thyroid hormones.…”

Section: Discussionmentioning

confidence: 99%

Melatonin usage in children and young adults, a registry-based cohort study

Tedroff

Euler

Dahlén

2022

European Journal of Paediatric Neurology

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Section: Discussionmentioning

confidence: 99%

Melatonin usage in children and young adults, a registry-based cohort study

Tedroff

Euler

Dahlén

2022

European Journal of Paediatric Neurology

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“…Basically, a fall in the production of testosterone is concomitant with certain consequences such as diminished sexual function, mood, energy, bone density, and muscle mass. Therefore, energy or cognitive function are not improved by increasing the serum testosterone of older men with low testosterone to that of young men even though bone density, sexual function, mood, walking, and ultimately sexual function are well improved [13,14].…”

Section: Reproductive Agingmentioning

confidence: 99%

Epigenetics in Reproductive Aging: Involvement of Oxidative Stress

Ogunro¹,

Babatunde²

2023

Epigenetics - Regulation and New Perspectives

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Epigenetic alterations are one of the distinctive characteristics of aging. Epigenetics changes throughout the reproductive life of humans. The major epigenetic parameters viz. DNA methylation, histone modification, and chromatin modeling are altered in the oocyte and sperm due to aging. Also, aging is accompanied by oxidative stress resulting in oocyte and sperm DNA damage. Oxidative stress occurs when the body’s antioxidant defense mechanism is overwhelmed by free radicals or pro-oxidant molecules such as nitrogen and reactive oxygen species, which are generated during normal cellular metabolism. This phenomenon is accompanied by a decline in the cell repair machinery, resulting in a wide range of DNA damage and distortion in cellular epigenetics. Still more, free radicals can directly or indirectly interfere with some epigenetic processes of the cell. For example, free radicals can impart the genome methylation profile by forming oxidized DNA lesions. Given the deleterious impact of oxidative stress on aging and cellular epigenetic profile, the ingestion of external antioxidants is encouraged to circumvent its side effects. This chapter provides insight into the interconnection between epigenetic alterations (histone modification, chromatin remodeling, DNA methylation and miRNA), reproductive aging, and oxidative stress.

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Testosterone replacement in men with sexual dysfunction

Lee,

Hwang,

et al. 2024

Cochrane Database of Systematic Reviews

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Testosterone supplementation in men with sexual dysfunction

Cited by 3 publications

References 72 publications

Melatonin usage in children and young adults, a registry-based cohort study

Melatonin usage in children and young adults, a registry-based cohort study

Epigenetics in Reproductive Aging: Involvement of Oxidative Stress

Testosterone replacement in men with sexual dysfunction

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