Testosterone therapy and prostate cancer

Pastuszak, Alexander W.; Rodríguez, Katherine; Nguyen, Taylor M.; Khera, Mohit

doi:10.21037/tau.2016.08.17

Cited by 19 publications

(11 citation statements)

References 95 publications

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“…Our method offers the possibility for researchers to quantify testosterone in nails in a simple, applicable way, and document stable long-term trends. For example, it may be useful for identifying changes in testosterone over months for diagnosing various diseases, as well as assessing therapy outcomes (Pastuszak et al 2016). Further development of a method for measuring testosterone in women's nails will aid diagnosing and treating polycystic ovarian disease (Ehrmann et al 1995) 190x142mm (300 x 300 DPI)…”

Section: Discussionmentioning

confidence: 99%

Age-related testosterone declines can be detected in men’s fingernails

Matas

Koren

2018

Can. J. Physiol. Pharmacol.

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Testosterone plays multiple roles in the regulation of development, physiology, reproduction, and behavior. Age-related testosterone declines are expected in the population. However, measuring circulating testosterone is especially challenging because concentrations are labile, responding to social situations and challenges. Matrices that integrate long-term testosterone levels are therefore valuable as biomarkers of endogenous levels as well as chronic exposures. Here, we report on a simple method to extract and measure accumulated testosterone from human fingernails using commercial enzyme immunoassay kits. Furthermore, we demonstrate known human testosterone sex and age trends. Our method is especially useful for quantifying testosterone in men's nails, where a small amount of matrix is required. Thus, this approach is a potential tool for biomonitoring endogenous as well as exogenous testosterone exposure. We suggest considering nails as an alternative matrix for quantifying other steroids as well.

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Section: Discussionmentioning

confidence: 99%

Age-related testosterone declines can be detected in men’s fingernails

Matas

Koren

2018

Can. J. Physiol. Pharmacol.

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“…Prostate safety remains one of the most important controversial issues of TTh since, historically, PC has been associated with an increased androgenicity [ 57 58 ]. Hence, clinicians and regulatory agencies are all concerned by the fact that TTh could cause or promote PC.…”

Section: Long Term Safety Of Testosterone Therapymentioning

confidence: 99%

“…Much evidence published in the two last decades has substantially better clarified the role of T in regulating prostate growth and differentiation [ 57 58 59 60 61 ]. Epidemiological studies have failed to find an association between endogenous T levels and risk of PC.…”

Section: Long Term Safety Of Testosterone Therapymentioning

confidence: 99%

Testosterone Replacement Therapy: Long-Term Safety and Efficacy

Corona

Sforza

Maggi

2017

World J Mens Health

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Recent position statements and guidelines have raised the distinction between a true and false, age-related hypogonadism (HG) or late-onset hypogonadism (LOH). The former is the consequence of congenital or acquired “organic” damage of the brain centers or of the testis. The latter is mainly secondary to age-related comorbidities and does not require testosterone (T) therapy (TTh). In addition, concerns related to cardiovascular (CV) safety have further increased the scepticism related to TTh. In this paper, we reviewed the available evidence supporting the efficacy of TTh in non-organic HG and its long term safety. A large amount of evidence has documented that sexual symptoms are the most specific correlates of T deficiency. TTh is able to improve all aspects of sexual function independent of the pathogenetic origin of the disease supporting the scientific demonstration that LOH does exist according to an “ex-juvantibus” criterion. Although the presence of metabolic derangements could mitigate the efficacy of TTh on erectile dysfunction, the positive effect of TTh on body composition and insulin sensitivity might counterbalance the lower efficacy. CV safety concerns related to TTh are essentially based on a limited number of observational and randomized controlled trials which present important methodological flaws. When HG is properly diagnosed and TTh correctly performed no CV and prostate risk have been documented.

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“…We should point out that the testosterone reposition therapy in men is still a controversial topic, especially in the men with a history of prostate cancer ( 41 ). The main concern is that testosterone may accelerate prostate growth not only in benign conditions but also in cancer.…”

Section: Discussionmentioning

confidence: 99%

The prostate after castration and hormone replacement in a rat model: structural and ultrastructural analysis

et al. 2017

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Purpose:To evaluate if late hormonal replacement is able to recover the prostatic tissue modified by androgenic deprivation.Materials and Methods:24 rats were assigned into a Sham group; an androgen deficient group, submitted to bilateral orchiectomy (Orch); and a group submitted to bilateral orchiectomy followed by testosterone replacement therapy (Orch+T). After 60 days from surgery blood was collected for determination of testosterone levels and the ventral prostate was collected for quantitative and qualitative microscopic analysis. The acinar epithelium height, the number of mast cells per field, and the densities of collagen fibers and acinar lumen were analyzed by stereological methods under light microscopy. The muscle fibers and types of collagen fibers were qualitatively assessed by scanning electron microscopy and polarization microscopy.Results:Hormone depletion (in group Orch) and return to normal levels (in group Orch+T) were effective as verified by serum testosterone analysis. The androgen deprivation promoted several alterations in the prostate: the acinar epithelium height diminished from 16.58±0.47 to 11.48±0.29μm; the number of mast cells per field presented increased from 0.45±0.07 to 2.83±0.25; collagen fibers density increased from 5.83±0.92 to 24.70±1.56%; and acinar lumen density decreased from 36.78±2.14 to 16.47±1.31%. Smooth muscle was also increased in Orch animals, and type I collagen fibers became more predominant in these animals. With the exception of the densities of collagen fibers and acinar lumen, in animals receiving testosterone replacement therapy all parameters became statistically similar to Sham. Collagen fibers density became lower and acinar lumen density became higher in Orch+T animals, when compared to Sham. This is the first study to demonstrate a relation between mast cells and testosterone levels in the prostate. This cells have been implicated in prostatic cancer and benign hyperplasia, although its specific role is not understood.Conclusion:Testosterone deprivation promotes major changes in the prostate of rats. The hormonal replacement therapy was effective in reversing these alterations.

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Testosterone therapy and prostate cancer

Cited by 19 publications

References 95 publications

Age-related testosterone declines can be detected in men’s fingernails

Age-related testosterone declines can be detected in men’s fingernails

Testosterone Replacement Therapy: Long-Term Safety and Efficacy

The prostate after castration and hormone replacement in a rat model: structural and ultrastructural analysis

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