Testosterone Therapy in Women With Chronic Heart Failure

Iellamo, Ferdinando; Volterrani, Maurizio; Caminiti, Giuseppe; Karam, Roger; Massaro, Rosalba; Fini, Massimo; Collins, Peter; Rosano, Giuseppe M.C.

doi:10.1016/j.jacc.2010.03.090

Cited by 183 publications

(70 citation statements)

References 38 publications

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“…39 Therefore, androgen deficiency may be involved in the imbalance between anabolic and catabolic processes and contribute to heart failure-induced muscle wasting and cachexia. 65 Testosterone supplementation was evaluated in small randomized double-blind studies including elderly men 66 and women 67 with heart failure. As testosterone improved functional capacity and muscle strength, it was hypothesized that it could be safe and useful in heart failure and cardiac cachexia.…”

Section: Cachexia Prevention and Treatmentmentioning

confidence: 99%

Cardiac Cachexia: Perspectives for Prevention and Treatment

Okoshi¹,

Capalbo²,

Romeiro³

et al. 2016

Arquivos Brasileiros De Cardiologia

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Cachexia is a prevalent pathological condition associated with chronic heart failure. Its occurrence predicts increased morbidity and mortality independent of important clinical variables such as age, ventricular function, or heart failure functional class. The clinical consequences of cachexia are dependent on both weight loss and systemic inflammation, which accompany cachexia development. Skeletal muscle wasting is an important component of cachexia; it often precedes cachexia development and predicts poor outcome in heart failure. Cachexia clinically affects several organs and systems. It is a multifactorial condition where underlying pathophysiological mechanisms are not completely understood making it difficult to develop specific prevention and treatment therapies. Preventive strategies have largely focused on muscle mass preservation. Different treatment options have been described, mostly in small clinical studies or experimental settings. These include nutritional support, neurohormonal blockade, reducing intestinal bacterial translocation, anemia and iron deficiency treatment, appetite stimulants, immunomodulatory agents, anabolic hormones, and physical exercise regimens. Currently, nonpharmacological therapy such as nutritional support and physical exercise are considered central to cachexia prevention and treatment.

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Section: Cachexia Prevention and Treatmentmentioning

confidence: 99%

Cardiac Cachexia: Perspectives for Prevention and Treatment

Okoshi¹,

Capalbo²,

Romeiro³

et al. 2016

Arquivos Brasileiros De Cardiologia

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show abstract

“…140–143 Toma et al performed a meta‐analysis of these studies and discovered that there was a net pooled improvement of 0.52 standard deviations in exercise capacity among those who were treated with testosterone. 144 The meta‐analysis revealed that patients treated with testosterone replacement therapy experienced an increase of 16.7% (equivalent to ≈54 m) in the 6‐minute walk test, an increase of 15.9% in the isometric walk test, and finally an increase of 22.7% in peak VO 2 .…”

Section: Testosterone and Congestive Heart Failurementioning

confidence: 99%

Testosterone and the Cardiovascular System: A Comprehensive Review of the Clinical Literature

Oskui

French

Herring

et al. 2013

JAHA

191

159

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“…However, peak oxygen uptake, Beck Depression Inventory, leg strength, and several quality of life components were more improved in former interventional group [27]. Similarly, Iellamo et al showed that 6MWD, peak oxygen consumption, maximal voluntary contraction, and peak torque increased significantly in testosterone group but remained unchanged in control group [28]. In a recent meta-analysis, a significant increase was shown in exercise capacity following testosterone therapy [29].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, association between the lack of testosterone and stimulating inflammatory responses has been shown and thus a remarkable improvement of cardiac performance and a significant decrease in the level of serum TNF-alpha following testosterone therapy has been suggested [33]. Along with the pointed mechanisms, a rise in hemoglobin [34], improvement of baroreceptor sensitivity [35], increase of muscle sympathetic nerve activity, and an increase of muscle arteriole vasodilation and function [36] have been also proposed. In addition, because insulin resistance is a major metabolic disturbance occurring in up to 40% of heart failure patients [37], this abnormality has been shown to be associated with low testosterone level leading decreased glucose utilization by skeletal muscle that results in muscle fatigue and wasting [38, 39].…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of Testosterone Therapy on Functional Capacity, Cardiovascular Parameters, and Quality of Life in Patients with Congestive Heart Failure

Mirdamadi

Garakyaraghi

Pourmoghaddas

et al. 2014

BioMed Research International

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Background. According to the present evidences suggesting association between low testosterone level and prediction of reduced exercise capacity as well as poor clinical outcome in patients with heart failure, we sought to determine if testosterone therapy improves clinical and cardiovascular conditions as well as quality of life status in patients with stable chronic heart failure. Methods. A total of 50 male patients who suffered from congestive heart failure were recruited in a double-blind, placebo-controlled trial and randomized to receive an intramuscular (gluteal) long-acting androgen injection (1 mL of testosterone enanthate 250 mg/mL) once every four weeks for 12 weeks or receive intramuscular injections of saline (1 mL of 0.9% wt/vol NaCl) with the same protocol. Results. The changes in body weight, hemodynamic parameters, and left ventricular dimensional echocardiographic indices were all comparable between the two groups. Regarding changes in diastolic functional state and using Tei index, this parameter was significantly improved. Unlike the group received placebo, those who received testosterone had a significant increasing trend in 6-walk mean distance (6MWD) parameter within the study period (P = 0.019). The discrepancy in the trends of changes in 6MWD between study groups remained significant after adjusting baseline variables (mean square = 243.262, F index = 4.402, and P = 0.045). Conclusion. Our study strengthens insights into the beneficial role of testosterone in improvement of functional capacity and quality of life in heart failure patients.

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Testosterone Therapy in Women With Chronic Heart Failure

Abstract: Testosterone supplementation improves functional capacity, insulin resistance, and muscle strength in women with advanced CHF. Testosterone seems to be an effective and safe therapy for elderly women with CHF.

Cited by 183 publications

References 38 publications

Cardiac Cachexia: Perspectives for Prevention and Treatment

Cardiac Cachexia: Perspectives for Prevention and Treatment

Testosterone and the Cardiovascular System: A Comprehensive Review of the Clinical Literature

Beneficial Effects of Testosterone Therapy on Functional Capacity, Cardiovascular Parameters, and Quality of Life in Patients with Congestive Heart Failure

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