Tests detecting biomarkers for screening of colorectal cancer: What is on the horizon?

Phalguni, Angaja; Seaman, Helen E.; Routh, Kristina; Halloran, Stephen P; Simpson, Sue

doi:10.3205/hta000122

GMS Health Technology Assessment; 11:Doc01; ISSN 1861-8863 2015

DOI: 10.3205/hta000122

|View full text |Cite

Tests detecting biomarkers for screening of colorectal cancer: What is on the horizon?

Angaja Phalguni

Helen E. Seaman

Kristina Routh

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2018

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 36 publications

(58 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

Electrochemically deposited silver detection substrate for surface-enhanced Raman spectroscopy cancer diagnostics

2018

J. Biomed. Opt.

View full text Add to dashboard Cite

Surface-enhanced Raman spectroscopy (SERS) of blood plasma on an electrochemically prepared silver surface has been studied as a label-free, noninvasive diagnostic test for colorectal cancer. Indium tin oxide glass substrates were modified with 0.01 mol dm - 3 silver nitrate using the pulsed double-potentiostatic method. The prepared silver substrates were tested with Rhodamine 6G as a model analyte and the surface with the highest signal enhancement was selected. This silver dendritic surface was used as a diagnostic substrate for SERS measurements of human blood plasma. A group of oncological patients with declared colorectal carcinoma (n = 15) and the control group of healthy volunteers (n = 15) were compared. The biomolecular changes in chemical composition in the cancer samples were detected by statistical processing of the resulting SERS spectra. About 94% specificity and 100% sensitivity were achieved for the analysis by the ratio of the SERS peak intensity at 725 cm - 1 for adenine to the peak intensity at 638 cm - 1 for tyrosine and 100% specificity and sensitivity by using principal component analysis. This method of SERS diagnostics of colorectal cancer, which does not require the nanoparticle preparation, mixing, and incubation of plasma with a colloidal solution as in conventional tests, is a rapid, inexpensive method, which could be introduced as a primary diagnostic test.

show abstract

Electrochemically deposited silver detection substrate for surface-enhanced Raman spectroscopy cancer diagnostics

2018

J. Biomed. Opt.

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Tests detecting biomarkers for screening of colorectal cancer: What is on the horizon?

Cited by 1 publication

References 36 publications

Electrochemically deposited silver detection substrate for surface-enhanced Raman spectroscopy cancer diagnostics

Electrochemically deposited silver detection substrate for surface-enhanced Raman spectroscopy cancer diagnostics

Contact Info

Product

Resources

About