Tests for Early Diagnosis of Cardiovascular Autonomic Neuropathy: Critical Analysis and Relevance

Rolim, Luiz Clemente; Souza, J.; Dib, Sérgio Atala

doi:10.3389/fendo.2013.00173

Cited by 36 publications

(33 citation statements)

References 18 publications

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“…In our study, we demonstrated a lower HRV (reduced LF, HF and total power) in the moderate/severe hypoglycemia group according to the HYPOsc, which is a comprehensive and thorough assessment of hypoglycemia. This can be explained by a greater impairment of the parasympathetic nervous system because the components of HF and total power reflect the parasympathetic activity and the parameter of LF reflects the sympathetic control with vagal modulation . The proportion of the low and high frequencies (LF/HF ratio) offers a relative indication of the sympathetic modulation of HRV .…”

Section: Discussionmentioning

confidence: 99%

Association between severity of hypoglycemia and loss of heart rate variability in patients with type 1 diabetes mellitus

Silva

Rolim

Filho

et al. 2016

Diabetes Metabolism Res

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Background The occurrence of hypoglycemia has been associated with the presence of cardiovascular autonomic neuropathy. Cardiovascular autonomic reflex tests are the gold standard diagnostic method for cardiovascular autonomic neuropathy. Nevertheless, impaired heart rate variability indices on spectral analysis have been reported before cardiovascular autonomic reflex test abnormalities arise. The objective of the present study was to analyse the association between the severity of hypoglycemia and indices of heart rate variability on spectral analysis.

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Section: Discussionmentioning

confidence: 99%

Association between severity of hypoglycemia and loss of heart rate variability in patients with type 1 diabetes mellitus

Silva

Rolim

Filho

et al. 2016

Diabetes Metabolism Res

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“…It is a noninvasive marker of the renin–angiotensin–aldo-sterone system, the cardiovascular control system, and the ANS (Rolim et al, 2013). The ANS regulates the operation of the internal organs to support the activity of the body and is composed of (a) the sympathetic nervous system, which prepares the body overall for activity, and (b) the parasympathetic nervous system, which has restorative functions such as digestion and slowing of the heartrate (Pocock and Richards, 1999).…”

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confidence: 99%

Leptin, adiponectin, and heart rate variability among police officers

Charles

Burchfiel

Sarkisian

et al. 2014

American J Hum Biol

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Objectives Police officers have a high prevalence of cardiovascular disease (CVD). Reduced heart rate variability (HRV) is known to increase CVD risk. Leptin and adiponectin may be related to CVD health. Therefore, our objective was to investigate the relationship between these variables and HRV. Methods Leptin and adiponectin levels were measured in 388 officers from the Buffalo Cardio-Metabolic Occupational Police Stress study. HRV was assessed according to methods published by the Task Force of the European Society of Cardiology and the North American Society of Pacing Electrophysiology for measurement and analysis of HRV. Mean values of high-frequency (HF) and low-frequency (LF) HRV were compared across tertiles of leptin and adiponectin using analysis of variance and analysis of covariance; trends were assessed using linear regression models. Results Leptin, but not adiponectin, was significantly and inversely associated with HRV. Body mass index (BMI) and percent body fat significantly modified the association between leptin and LF (but not HF) HRV. Among officers with BMI < 25 kg/m2, leptin was not significantly associated with HRV. However, among officers with BMI ≥ 25 kg/m2, leptin was inversely associated with HRV, after adjustment for age, gender, and race/ethnicity; HF HRV, P = 0.019 and LF HRV, P < 0.0001. Similarly, among officers with percent body fat ≥ 25.5%, leptin and LF HRV showed significant, inverse associations (adjusted P = 0.001). Conclusions Leptin levels were inversely associated with LF HRV, especially among officers with increased adiposity. Increased leptin levels may be associated with CVD-related health problems.

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“…Those who answered positively for the presence of resting tachycardia, intermittent blurry vision, posture instability, syncope, postprandial hypotension and intolerance to physical exercise, were further analyzed for their electrocardiograms, deep breathing, heart rate variability and orthostatic hypotension [9,[16][17][18]. Only seven patients were diagnosed with pure autonomic neuropathy (DAN) in the original group.…”

Section: Classification Criteria For Diabetic Neuropathiesmentioning

confidence: 99%

Neuropathy-specific alterations in a Mexican population of diabetic patients

et al. 2017

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Background: Neuropathy is one of the major complications of type 2 diabetes mellitus. Our first aim was to determine the clinical characteristics of a population of diabetic patients with different types of neuropathy. Our next goal was to characterize the cytokine profile (IL-6 and IL-10), nerve growth factor (NGF) and circulating celladhesion molecules in these patients. Finally, we aimed to compare the renal function among the groups of neuropathic patients. Methods: In a cross-sectional study, we included 217 diabetic patients classified in three groups: sensory polyneuropathy with hypoesthesia (DS h P) or hyperesthesia (DS H P), and motor neuropathy (DMN). Two control groups were included: one of 26 diabetic non-neuropathic patients (DNN), and the other of 375 non-diabetic (ND) healthy subjects. The participants were attending to the Mexican Institute of Social Security. Results: The circulating levels of NGF were significantly lower in diabetic patients, compared to healthy subjects. The range of IL-6 and IL-10 levels in neuropathic patients was higher than the control groups; however, several samples yielded null measurements. Neuropathic patients also showed increased circulating levels of the adhesion molecules ICAM, VCAM, and E-Selectin, compared to the ND group. Moreover, neuropathic patients showed reduced glomerular filtration rates compared to healthy subjects (82-103 ml/min per 1.73 m 2 , data as range from 25th-75th percentiles), especially in the group with DMN (45-76 ml/min per 1.73 m 2 ).

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Tests for Early Diagnosis of Cardiovascular Autonomic Neuropathy: Critical Analysis and Relevance

Cited by 36 publications

References 18 publications

Association between severity of hypoglycemia and loss of heart rate variability in patients with type 1 diabetes mellitus

Association between severity of hypoglycemia and loss of heart rate variability in patients with type 1 diabetes mellitus

Leptin, adiponectin, and heart rate variability among police officers

Neuropathy-specific alterations in a Mexican population of diabetic patients

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