Tests for learning and memory in rodent regulatory studies

Vorhees, Charles V.; Williams, Michael T.

doi:10.1016/j.crtox.2024.100151

Cited by 7 publications

(1 citation statement)

References 172 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Associative learning can modify the activity of numerous neurons which are distributed in cortical and subcortical regions. In contrast, individual neurons modify the frequency or rate of spike patterns in response to environmental stimuli as they are associated with important outcomes [9,10].…”

Section: Introductionmentioning

confidence: 99%

Application Of Herrmann's Brain Quadrant Model and its Relationship with Learning Styles in Anesthesiology Residents

Ortega-Barreiro,

Almanzor-Gasca,

Gonzalez-Ojeda

et al. 2024

Preprint

View full text Add to dashboard Cite

Background: In the field of medicine, the ability to learn and adapt to clinical demands is essential in the training of residents. The Herrmann Brain Model categorizes thinking styles based on the preference for utilizing brain quadrants, serving as an applied tool for residents to assess their learning preferences. Objective: This study aims to delineate the learning styles according to Herrmann's brain quadrant model among anesthesiology residents at the Hospital de Especialidades de Centro Médico Nacional de Occidente. Materials and Methods: A cross-sectional descriptive study was conducted. Anesthesiology residents were enrolled, and the Herrmann Brain Dominance Test was administered. Each brain quadrant embodies distinct characteristics, thinking patterns, and approaches to knowledge acquisition. The test comprises 120 multiple-choice items on academic, daily, and professional scenarios. The quadrants are described as follows: LC "Scientific Expert," LL "Organizer-Introvert," RC "Interpersonal Strategist," RL "Imaginative Communicator." Results: Twenty-seven residents participated, with an average age of 28.4 ± 1.4 years (12 [44.4%] female and 15 [55.5%] male). According to the dominance test, the predominant cerebral hemisphere was quadrant LC in 8 residents (29.6%), 6 with LC/RC (22.2%), 6 with LC/LL (22.2%), 3 with CD (11.1%), 2 with LL (7.4%), and 1 with LL/RC (3.7%). One case exhibited no dominance, represented graphically as "None" (3.7%). Conclusion: Utilizing this model among residents revealed that the left cortical quadrant, designated as the "scientific expert," exhibited the highest dominance. A logical, analytical, and rational personality characterizes this quadrant.

show abstract

Section: Introductionmentioning

confidence: 99%

Application Of Herrmann's Brain Quadrant Model and its Relationship with Learning Styles in Anesthesiology Residents

Ortega-Barreiro,

Almanzor-Gasca,

Gonzalez-Ojeda

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Orofacial pain models induce impairment in spatial learning and working memory in rodents: A systematic review and meta-analysis

Viero,

Felix Morais,

Rodrigues

et al. 2025

European Journal of Pharmacology

View full text Add to dashboard Cite

Cognitive improvement via cortical cannabinoid receptors and choline‐containing lipids

Moreno‐Rodríguez,

Martínez‐Gardeazabal,

Bengoetxea de Tena

et al. 2024

British J Pharmacology

View full text Add to dashboard Cite

Background and PurposeRecent research linking choline‐containing lipids to degeneration of basal forebrain cholinergic neurons in neuropathological states illustrates the challenge of balancing lipid integrity with optimal acetylcholine levels, essential for memory preservation. The endocannabinoid system influences learning and memory processes regulated by cholinergic neurotransmission. Therefore, we hypothesised that activation of the endocannabinoid system may confer neuroprotection against cholinergic degeneration.Experimental ApproachWe examined the neuroprotective potential of sub‐chronic treatments with the cannabinoid agonist WIN55,212‐2, using ex vivo organotypic tissue cultures including nucleus basalis magnocellularis and cortex and in vivo rat models of specific cholinergic damage induced by 192IgG‐saporin. Levels of lipids, choline and acetylcholine were measured with histochemical and immunofluorescence assays, along with [35S]GTPγS autoradiography of cannabinoid and muscarinic GPCRs and MALDI‐mass spectrometry imaging analysis. Learning and memory were assessed by the Barnes maze and the novel object recognition test in rats and in the 3xTg‐AD mouse model.Key ResultsDegeneration, induced by 192IgG‐saporin, of baso‐cortical cholinergic pathways resulted in memory deficits and decreased cortical levels of lysophosphatidylcholines (LPC). WIN55,212‐2 restored cortical cholinergic transmission and LPC levels via activation of cannabinoid receptors. This activation altered cortical lipid homeostasis mainly by reducing sphingomyelins in lesioned animals. These modifications were crucial for memory recovery.Conclusion and ImplicationsWe hypothesise that WIN55,212‐2 facilitates an alternative choline source by breaking down sphingomyelins, leading to elevated cortical acetylcholine levels and LPCs. These results imply that altering choline‐containing lipids via activation of cannabinoid receptors presents a promising therapeutic approach for dementia linked to cholinergic dysfunction.

show abstract

Tests for learning and memory in rodent regulatory studies

Cited by 7 publications

References 172 publications

Application Of Herrmann's Brain Quadrant Model and its Relationship with Learning Styles in Anesthesiology Residents

Application Of Herrmann's Brain Quadrant Model and its Relationship with Learning Styles in Anesthesiology Residents

Orofacial pain models induce impairment in spatial learning and working memory in rodents: A systematic review and meta-analysis

Cognitive improvement via cortical cannabinoid receptors and choline‐containing lipids

Contact Info

Product

Resources

About