Tests of Phosphate Reabsorption

Kenny, A. P.; Glen, A.I.M.

doi:10.1016/s0140-6736(73)93112-7

Cited by 49 publications

(23 citation statements)

References 4 publications

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“…The tubular maximum reabsorption of phosphorus per glomerular filtration rate (TmP/GFR [mg/dL]) can be calculated by the following equation [22]: If TRP is ≤ 0.86 (86%), then TmP/GFR = TRP × (serum phosphate). If TRP is > 0.86 (86%), then TmP/GFR = (0.3 × TRP)/(1–0.8 × TRP)x(serum phosphate) [23].…”

Section: Methodsmentioning

confidence: 99%

Association of serum levels of FGF23 and α-Klotho with glomerular filtration rate and proteinuria among cardiac patients

et al. 2014

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BackgroundExpression and/or excretion of fibroblast growth factor-23 (FGF23) and its co-receptor Klotho are altered in patients with end-stage renal disease. The possibility that the FGF23/α-Klotho system mediates the aggravated cardiovascular outcome among patients with chronic kidney disease (CKD) has been suggested. We determined whether FGF23 and α-Klotho concentrations are altered among patients with reduced renal function and proteinuria.MethodsSerum FGF23 and α-Klotho were measured in cardiology patients who were not undergoing chronic hemodialysis. Estimated glomerular filtration rate (eGFR) was correlated negatively with FGF23 and positively with α-Klotho.ResultsThe correlation between FGF23 and the renal tubular maximum reabsorption rate of phosphate to the GFR (TmP/GFR) was not significant, but that between FGF23 and serum calcium or inorganic phosphate was significant among patients with an estimated GFR of less than 60 mL/min/m2. By stepwise multivariate regression analysis, eGFR was selected as significant predictor for FGF23 or α-Klotho among patients with an estimated GFR of less than 60 mL/min/m2; however, urine albumin/creatinine ratio was not selected as a predictor for FGF23 or α-Klotho irrespective of the eGFR levels. In patients with eGFR of <60 mL/min/1.73 m2, UACR was significantly associated with log(FGF23); but, this association did not remain statistically significant in a multivariate model.ConclusionsAmong cardiology patients with various stages of CKD, serum concentrations of FGF23 and α-Klotho were associated with renal function, but not with the extent of proteinuria.

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Section: Methodsmentioning

confidence: 99%

Association of serum levels of FGF23 and α-Klotho with glomerular filtration rate and proteinuria among cardiac patients

et al. 2014

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“…Renal phosphate handling was assessed by calculating the TmP/GFR using serum samples obtained after an overnight fast and urine samples from 24-hour urine collections, using an adaptation of the technique and nomogram of Walton and Bijovet (24,34,35). Patients were considered to have normal excretion of phosphate in the urine (non-phosphate wasters, NPW) or renal phosphate wasting (phosphate wasters, PW) if their value of TmP/GFR was higher or lower, respectively, than the lower limit of the ageand gender-specific normal range (36).…”

Section: Methodsmentioning

confidence: 99%

FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting

Riminucci¹,

Collins²,

Fedarko³

et al. 2003

J. Clin. Invest.

581

319

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FGF-23, a novel member of the FGF family, is the product of the gene mutated in autosomal dominant hypophosphatemic rickets (ADHR). FGF-23 has been proposed as a circulating factor causing renal phosphate wasting not only in ADHR (as a result of inadequate degradation), but also in tumor-induced osteomalacia (as a result of excess synthesis by tumor cells). Renal phosphate wasting occurs in approximately 50% of patients with McCune-Albright syndrome (MAS) and fibrous dysplasia of bone (FD), which result from postzygotic mutations of the GNAS1 gene. We found that FGF-23 is produced by normal and FD osteoprogenitors and bone-forming cells in vivo and in vitro. In situ hybridization analysis of FGF-23 mRNA expression identified "fibrous" cells, osteogenic cells, and cells associated with microvascular walls as specific cellular sources of FGF-23 in FD. Serum levels of FGF-23 were increased in FD/MAS patients compared with normal age-matched controls and significantly higher in FD/MAS patients with renal phosphate wasting compared with those without, and correlated with disease burden bone turnover markers commonly used to assess disease activity. Production of FGF-23 by FD tissue may play an important role in the renal phosphate-wasting syndrome associated with FD/MAS

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“…Urinary calcium and phosphate excretion were expressed as a function of glomerular filtration by multiplying the urinary analyte/creatinine ratio with the corresponding serum creatinine concentration. For phosphate excretion a correction both for glomerular filtration and prevailing plasma phosphate could be made by calculation of the renal tubular threshold for phosphate (TmP04/GFR), using the normogram of Bijvoet & Morgan (10). Reference values for these parameters established by Shaw et al in children between 2 and 15 years old were used (1 I).…”

Section: Methodsmentioning

confidence: 99%

Renal function abnormalities after ifosfamide treatment in children

Schepper¹,

Hachimi-Idrissi²,

Verboven³

et al. 1993

Acta Paediatrica

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Renal function was evaluated in 12 children (aged 2.5-17.5 years) who received ifosfamide as part of their chemotherapy for different malignancies. A blood and urine analysis evaluating renal glomerular and tubular function and an isotopic determination of glomerular filtration were carried out four months or later after treatment had been stopped. Three patients had several biochemical abnormalities suggesting a significant degree of proximal renal dysfunction (increased urinary excretion of calcium, glucose, beta 2-microglobulin, amino acids (three patients) and decreased tubular reabsorption of phosphate (one patient)). The tubular dysfunction in these patients was associated with a diminished glomerular filtration. These patients could be characterized by their younger age at treatment and a higher dose of ifosfamide received if calculated per kg body weight.

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Tests of Phosphate Reabsorption

Cited by 49 publications

References 4 publications

Association of serum levels of FGF23 and α-Klotho with glomerular filtration rate and proteinuria among cardiac patients

Association of serum levels of FGF23 and α-Klotho with glomerular filtration rate and proteinuria among cardiac patients

FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting

Renal function abnormalities after ifosfamide treatment in children

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