2022
DOI: 10.1007/s12640-022-00505-7
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Tet Enzymes-Mediated DNA 5hmC Modification in Cerebral Ischemic and Hemorrhagic Injury

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Cited by 4 publications
(3 citation statements)
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“…DNA methylation changes related to mitochondrial dysfunction show increased Timp-2 methylation and decreased Mmp-9 methylation through regulated expression and activity of DNMT1 and DNMT3a [ 48 ]. In demethylation of mitochondrial DNA, the level of mitochondrial TET2-mediated 5hmC increased after ischemic brain injury, resulting in increased expression of six mitochondrial genes (ND2, ND3, ND4L, ND5, ND6, and COX3) [ 51 ].…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…DNA methylation changes related to mitochondrial dysfunction show increased Timp-2 methylation and decreased Mmp-9 methylation through regulated expression and activity of DNMT1 and DNMT3a [ 48 ]. In demethylation of mitochondrial DNA, the level of mitochondrial TET2-mediated 5hmC increased after ischemic brain injury, resulting in increased expression of six mitochondrial genes (ND2, ND3, ND4L, ND5, ND6, and COX3) [ 51 ].…”
Section: Resultsmentioning
confidence: 99%
“…In a study on the demethylation mechanism after ischemic injury, an increase in mitochondrial TET2 expression resulted in an increase in mitochondrial DNA 5hmC without a change in the level of 5mc, and the increased 5hmC increased the mRNA level of mitochondrial genes. The gene includes the subunits (ND2, ND3, ND4L, ND5, and DN6) of complex 1 (NADH: ubiquinone oxidoreductase) and the COX3 subunit of complex 4 (cytochrome c oxygenase) [ 50 , 51 ].…”
Section: Dna Methylation In Neuroprotection After Strokementioning
confidence: 99%
“…Specifically, the epigenetic modification 5hmC has recently garnered research attention, with TET family proteins identified as its regulators. 46 , 47 Alcohol consumption can induce cellular damage and alter the epigenetic landscape. 48 A previous study found that chronic ethanol exposure leads to hepatocyte apoptosis, accompanied by diminished TET1 levels and heightened 5hmC formation.…”
Section: Discussionmentioning
confidence: 99%