TET1 and TDG Suppress Inflammatory Response in Intestinal Tumorigenesis: Implications for Colorectal Tumors With the CpG Island Methylator Phenotype

Tricarico, Rossella; Madžo, Jozef; Scher, Gabrielle; Cohen, Maya; Jelı́nek, Jaroslav; Maegawa, Satoru; Nagarathinam, Rajeswari; Scher, Carly; Chang, Wen‐Chi L.; Nicolas, Émmanuelle; Slifker, Michael; Zhou, Yan; Devarajan, Karthik; Cai, Kathy Q.; Kwok, Tim Tak; Nakajima, Pamela B.; Xu, Jiawen; Mancuso, Pietro; Doneddu, Valentina; Bagella, Luigi; Williams, Riley; Balachandran, Siddharth; Maskalenko, Nicholas; Campbell, Kerry S.; Ma, Xueying; Cañadas, Israel; Viana, Julen; Valle, Laura; Grivennikov, Sergei I.; Peshkova, Iuliia O.; Kurilenko, N. V.; Mazitova, Aleksandra M.; Koltsova, Ekaterina K.; Lee, Hayan; Walsh, Martin J.; Duttweiler, Reuben R.; Whetstine, Johnathan R.; Yen, Timothy; Issa, Jean-Pierre J.; Bellacosa, Alfonso

doi:10.1053/j.gastro.2023.01.039

Cited by 13 publications

(7 citation statements)

References 54 publications

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“…Then, the specificity of APE1 was evaluated, as shown in Figure C. The DNA-repair enzymes, such as UDG, TDG, TE, and hAAG, were unable to activate the preprobe, there were minimal fluorescence changes even supplied with high concentrations of miR-21. The sensing specificity of E-DNA walker toward miR-21 was evaluated against miR-429, miR-155, miR-141, miR-31, and let-7a since these related miRNAs are often reported to be overexpressed intracellularly .…”

Section: Resultsmentioning

confidence: 99%

Endogenously Gated DNA Walking Machine for Prescreened MicroRNA Detection in Extracellular Vesicles

Chen,

Sun,

Mao

et al. 2024

Anal. Chem.

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Tumor-derived extracellular vesicle (T-EV) microRNAs have been investigated as promising biomarkers in clinical diagnosis as well as disease progression monitoring. However, the expression profiles of microRNA in different tissues vary widely, the precise monitoring of microRNA levels in EVs originating from diseased tissues is susceptible to background interference, thus remains a challenge. Conventional assays require extensive processing, such as EV isolation and even sample lysis, which is both slow and laborious, and the cumbersome pretreatment could spoil the downstream analysis. To address this issue, we developed a generalizable strategy for T-EVs-selective activation and therefore specific amplified microRNA imaging. The conditional signal amplification is established by integrating a traditional DNA walker system with endogenously activated motif to achieve sensitized microRNA imaging in T-EVs. The preorganized endogenous activation with additional sensing criteria narrowed the scope against the complex specimens, and the amplified sensing with reduced off-target signals was supposed to be sensitive to monitor the tiny changes of microRNA expression during the disease course, which holds great potential for accurate diagnosis and prognosis.

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Section: Resultsmentioning

confidence: 99%

Endogenously Gated DNA Walking Machine for Prescreened MicroRNA Detection in Extracellular Vesicles

Chen,

Sun,

Mao

et al. 2024

Anal. Chem.

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“…Recent work by Tricarico et al demonstrated that inactivation of Tet1-Tdg induced hypermethylation in CpG islands using the Tet1 –/– Tdg N151/+ Apc Min/+ mutant mouse model. 69 TET family inactivation by the oncometabolite, D-2-hydroxyglutarate (D-2HG), resulting from IDH1/2 mutation, is a well-known cause of CIMP in glioma. 6 The absence of TET or IDH mutations in CRC CIMP 70 suggests that the gut microbiota may play a role in TET inactivation.…”

Section: Discussionmentioning

confidence: 99%

Association between gut microbiota and CpG island methylator phenotype in colorectal cancer

Park,

Keith,

Calendo

et al. 2024

Gut Microbes

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“…TET dioxygenases are crucial for maintaining DNA methylation levels, as they collaborate with TDG to initiate DNA demethylation. Inactivation of these enzymes leads to the hypermethylation of DNA, resulting in severe disturbances in gene expression and increased incidence of tumor development and embryonic lethality in mice [ 116 , 292 , 293 , 294 ]. As a result, alterations in TETs and TDG have the potential to serve as drivers of cancer, even though only aberrations and mutations in TET family genes have been found in tumors.…”

Section: Inflammation Epigenetics and Cancermentioning

confidence: 99%

The Killer’s Web: Interconnection between Inflammation, Epigenetics and Nutrition in Cancer

Mecca,

Picerno,

Cortellino

2024

IJMS

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Inflammation is a key contributor to both the initiation and progression of tumors, and it can be triggered by genetic instability within tumors, as well as by lifestyle and dietary factors. The inflammatory response plays a critical role in the genetic and epigenetic reprogramming of tumor cells, as well as in the cells that comprise the tumor microenvironment. Cells in the microenvironment acquire a phenotype that promotes immune evasion, progression, and metastasis. We will review the mechanisms and pathways involved in the interaction between tumors, inflammation, and nutrition, the limitations of current therapies, and discuss potential future therapeutic approaches.

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TET1 and TDG Suppress Inflammatory Response in Intestinal Tumorigenesis: Implications for Colorectal Tumors With the CpG Island Methylator Phenotype

Cited by 13 publications

References 54 publications

Endogenously Gated DNA Walking Machine for Prescreened MicroRNA Detection in Extracellular Vesicles

Endogenously Gated DNA Walking Machine for Prescreened MicroRNA Detection in Extracellular Vesicles

Association between gut microbiota and CpG island methylator phenotype in colorectal cancer

The Killer’s Web: Interconnection between Inflammation, Epigenetics and Nutrition in Cancer

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