Tetanolysin: In-Vivo Effects in Animals

Mc, Hardegree; Ae, Palmer; Duffin, N

doi:10.1093/infdis/123.1.51

Cited by 19 publications

(8 citation statements)

References 27 publications

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“…It has been suggested that tetanolysin contributes little or nothing to the toxicity of C. tetani (21) in vivo. In view of our previously reported findings (12) and the present data showing that tetanolysin disrupts cellular and subcellular membrane structures with the release of biologically active amines and hydrolytic enzymes, further examination of the role of this bacterial toxin in some of the unusual manifestations of tetanus and the prophylactic and therapeutic need for antibody should be considered.…”

Section: Fig 2 (A)mentioning

confidence: 83%

“…None of the oxygen-labile hemolysins have been assigned a role in human disease, although much effort has gone into implicating streptolysin 0 in the pathogenesis of streptococcal illness (8,10). A previous report from our laboratory showed that partially purified tetanolysin was cardiotoxic for mice and monkeys, lethal for mice, and induced hemolysis in vivo after intravenous injection, and suggested that some of the complications of clinical tetanus, such as cardiovascular alterations, hemolysis, and anemia might be due, in part, to the tetanolysin (12).…”

Section: Fig 2 (A)mentioning

confidence: 92%

“…Some of these toxins (i.e., streptolysin 0 and the hemolysin of Listeria monocytogenes) belong to the group of bacterial products known as oxygen-labile hemolysins (2). Tetanolysin, the hemolysin produced by Clostridium tetani, shares many of the properties of other oxygenlabile hemolysins (2,12), but its effect on platelets and lysosomes has not been previously reported. Data are presented in this report to show that a partially purified preparation of tetanolysin can be added to the list of toxins that disrupt a variety of membranes in vitro.…”

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confidence: 99%

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Effect of Tetanolysin on Platelets and Lysosomes

1974

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Tetanolysin, partially purified, caused the lysis of human and rabbit platelets, as determined by a decrease in the optical density of platelet suspensions and the release of serotonin, enzymes, and protein. This lytic activity was neutralized by antitoxin. In addition, a suspension of the lysosome-containing large granule fraction of rabbit liver released hydrolytic enzymes when exposed to tetanolysin. Thus, tetanolysin can be added to the list of bacterial toxins that are lytic for a variety of cellular or subcellular membranes. These findings provide additional data that suggest that tetanolysin may contribute to the pathogenesis of some of the unusual manifestations observed in clinical tetanus.

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Section: Fig 2 (A)mentioning

confidence: 83%

Section: Fig 2 (A)mentioning

confidence: 92%

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confidence: 99%

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Effect of Tetanolysin on Platelets and Lysosomes

1974

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“…Streptolysin 0 and pneumolysin possess considerable homology, with a common identical 12-amino-acid segment. Oxygen-labile hemolysins have been shown to have lethal and cardiotoxic effects in vivo and to cause intravascular lysis (26,117). The role they play in diseases caused by the organisms that produce them is difficult to assess.…”

Section: Oxygen-labile Hemolysinsmentioning

confidence: 99%

Toxigenic clostridia

1990

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Toxigenic clostridia belonging to 13 recognized species are discussed in this review. Each species or group of organisms is, in general, introduced by presenting the historical aspects of its discovery by early investigators of human and animal diseases. The diseases caused by each species or group are described and usually discussed in relation to the toxins involved in the pathology. Morphological and physiological characteristics of the organisms are described. Finally, the toxins produced by each organism are listed, with a presentation of their biological activities and physical and biochemical characteristics. The complete amino acid sequences for some are known, and some of the genes have been cloned. The term toxin is used loosely to include the various antigenic protein products of these organisms with biological and serological activities which have served as distinguishing characteristics for differentiation and classification. Some of these factors are not truly toxic and have no known role in pathogenicity. Some of the interesting factors common to more than one species or group are the following: neurotoxins, lethal toxins, lecithinases, oxygen-labile hemolysins, binary toxins, and ADP-ribosyltransferases. Problems in bacterial nomenclature and designation of biologically active factors are noted.

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“…The active toxin has an affinity for cholesterol and related sterols, and its lytic and lethal activities are inhibited by these compounds. Hardegree et al (1971) showed in vivo effects of tetanolysin after intravenous injection into animals. In mice, pulmonary edema rapidly developed, followed by death.…”

Section: Culture and Isolationmentioning

confidence: 99%

Clostridium botulinumandClostridium tetani

Johnson

2010

Topley &Amp; Wilson's Microbiology and Microbial Infections

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Tetanolysin: In-Vivo Effects in Animals

Cited by 19 publications

References 27 publications

Effect of Tetanolysin on Platelets and Lysosomes

Effect of Tetanolysin on Platelets and Lysosomes

Toxigenic clostridia

Clostridium botulinumandClostridium tetani

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